DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRIIC and glr-8

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_001368711.1	Gene:	glr-8 / 180924	WormBaseID:	WBGene00001619	Length:	547	Species:	Caenorhabditis elegans

Alignment Length:	437	Identity:	92/437 - (21%)
Similarity:	166/437 - (37%)	Gaps:	50/437 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   425 VATRIGPPYFSYNETARELNLTGNALYQGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQ 489
            |...|.|||.:|...: :..:|......|..::::..|.:.:...|..:|.....:|  :.....
Worm    67 VVPAIEPPYVNYVNFS-DAAVTDKGYGPGVVMEILKEIGKRLNLTYEILPALGSTWG--EYLNGS 128

  Fly   490 WNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFM--QLGVSILAYKSP--HVEKTLDAYLAP 550
            |.|..|:::..:..:......:...|....|.|.||.  ..|:.|   :||  :.:.||.....|
Worm   129 WTGAFGQLVRGEVDLLAGGAIMEYDRSVIADLTYPFQFEPTGIMI---RSPEKYEDDTLLIVTEP 190

  Fly   551 FGGEVWI----WILISVFVMTFLKTIVARISKMDWENPHPCNRDPEVLENQWRIHNTGWLTVASI 611
            |..|||:    .||||..:...:..|:.::.:.....|                ..:.|:..:..
Worm   191 FSWEVWVITAAVILISGVIFLVMTNIIRKVYEEMTVTP----------------FESIWVFFSIF 239

  Fly   612 MTAGCDILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDL-SAQKKVKFG 675
            :..|....|||...|:..|.||:.:|.::.::|.:|.|.....|......|:..| ...|:.||.
Worm   240 VQQGLPEQPRSWSCRVLVALWWLASITLSATFTGSLVALFAVDKTNVPFQNIDQLVRLVKQGKFE 304

  Fly   676 TIYGGSTY---NLLADSNETVYRLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFLMETTTLE 737
            .:...:::   .::|.|...|||..::.|..:....|......||..||.|.| |..|....||.
Worm   305 IVMDENSFTRTEMIARSKLPVYRDLWHEMIVNHKVKYVNGIARGVAFVRANPG-YALLGPMATLN 368

  Fly   738 YHREQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKW---------W 793
            ::...:|.:....:.....:.:|.:...:.|....|..|.::.|||    ..|||         .
Worm   369 FYAYSDCKVILFNDGILPVYLSIPLVKNSIYSPYFSTKIREMVERG----FTQKWIADYRSYVAM 429

  Fly   794 KNPNASCFEEPDPDATPDMTFEELRGIFYTLYAGILIAFLIGITEFL 840
            :..|........|.:..|:  :..:|.|:....|..:...:.:.||:
Worm   430 QKINECNSTTIGPKSYLDL--KRAQGAFWVFLGGAGLGLALFVGEFI 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141
		PBP2_iGluR_Kainate	423..794	CDD:270432	84/389 (22%)
		Lig_chan	554..828	CDD:278489	61/290 (21%)
glr-8	NP_001368711.1	PBP2_iGluR_ligand_binding	62..424	CDD:270219	84/383 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910