DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIC and glr-7

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_001337310.1	Gene:	glr-7 / 180547	WormBaseID:	WBGene00001618	Length:	885	Species:	Caenorhabditis elegans

Alignment Length:	885	Identity:	216/885 - (24%)
Similarity:	355/885 - (40%)	Gaps:	186/885 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 CDLIDNGVAAIFGPSSKAASDIVALVCNSTGIPHIEFDISDEGI----------QAEKPNH-QMT 134
            ||.:.|....|....|..:..:||.:...:.:|.|:.|::...:          ....|:: .|.
Worm    29 CDQMVNVSFVISVCRSNDSISLVAELARISQVPTIQVDLNYWSLPLNFNGTSVPTISSPSYTTMV 93

  Fly   135 LNLYPAQAILSKAYAD--IVQNFGWRKFTIVYDADDARAAARLQDLLQLREVHNDVVRVRKFHKD 197
            |:....|.:::..:||  |..|     .|::||      .....|....|:..:.:..:|....:
Worm    94 LSTLVFQNVITDIFADLNITPN-----STVLYD------NMYPPDFTAWRDAFSVLPGIRFVPME 147

  Fly   198 DDFRVMWKSIRGERRVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNLETYT----DHLEELAA 258
            .....|...|...|...:    |.|:  |.:.||             |:|.:|    |.:|:...
Worm   148 TTVLRMRAQITQLRMASI----NSLI--LVAKTE-------------NVERFTLEAADFIEQRVF 193

  Fly   259 DNETFAVNITAAR---------LLVNPDPPPYSLPYGYVTQ-RDNIVYESSDPPRTLIHDLIHDA 313
            :......:|||.:         ..:.|      .|.|.:.: ||...|        |..:.|...
Worm   194 NTYVLTKDITAFKCDSCESAFMFWLRP------FPVGKLMEIRDLDDY--------LFRNEIGLE 244

  Fly   314 LQLFAQSWRNASF-FYPDRM---------------VVPRITCDFAAS-------------GGRTW 349
            |......|.:.:. ||.:.|               |:|..||....|             .....
Worm   245 LDYSINGWDSLNVAFYMNVMGYAFETIRTMNATFDVLPTFTCQTGPSEPNITTTVRDIILNDPAH 309

  Fly   350 AMGRYLARLMKGTSGVN----NTNFRTSILQFDEDGQRITFNIEVYDPLDGIGIAIWDPRGQIT- 409
            ..|.|.      .:|:|    :...|...:..|.|.:...||.||         .:|.|..:::
Worm   310 EYGNYT------EAGLNMFFQDVEVRIYKIDRDRDHEDALFNKEV---------GVWSPISKLSV 359

  Fly   410 ---QLNVDVKAQKKMIYRVATRIGPPYFSYNETARELNLTG--NALYQGYAVDLIDAIARHVGFE 469
               .|.|||:  ...|:||.|.|.||:         :..||  :..|:||.:|||:.|...|.|.
Worm   360 MYGTLQVDVR--NLNIFRVVTLIQPPF---------VQRTGDPDTPYEGYCIDLINMIQVEVNFT 413

  Fly   470 YVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILA 534
            |....|.|..:|.:| :...|||:||.:::..|.:.:..|::...|:..||||||:..|..:.:.
Worm   414 YTIYEVEDGSFGTMD-DNGNWNGLIGALVSGSADIALAPLSVMAERENDVDFTVPYYDLVGTTIL 477

  Fly   535 YKSPHVEKTLDAYLAPFGGEVWIWILISVFVMTFLKTIVARISKMDWENPHPCNRD---PEVLEN 596
            .|...||.:|..::......||:.|:.:....:.|..|..|.|...:.|    |::   .::.:.
Worm   478 MKKADVEYSLFKFMKVLEWPVWLCIVAAYLFTSILLWIFDRFSPYSFTN----NKERYQNDIEKR 538

  Fly   597 QWRIHNTGWLTVASIMTAGCDILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIA 661
            |:.:....|..:.|:...|....|::...|:..||||:|..||..|||||||||||.|::|..|:
Worm   539 QFSLKECLWFCMTSLTPQGGGEAPKNISGRLVAATWWLFGFIIIASYTANLAAFLTVSRLEQPIS 603

  Fly   662 NLKDLSAQKKVKFGTIYGGST---YNLLADSNETVYRLAFNLMNNDDPSAYTKDNL--------- 714
            :|.||:.|.|:::..|.|.::   :..:|:..||.|.:...:..|:..|...:..|
Worm   604 SLDDLAKQYKIEYAPIKGSASETYFRRMAEIEETFYNMWKEMSLNESMSPRDRAKLAVWDYPVSD 668

  Fly   715 -------------------EGVDRVRKNRGDYMFLMETTTLEYHREQNCDLRSVGEKFGEKHYAI 760
                               ..||||..:...:.|:.:.|.::|....||:|:.||.:|..|.|||
Worm   669 KFTNMWRYMQESKLPVNMDTAVDRVLNSVDGFAFIGDATEIKYAALTNCNLQQVGTEFSRKPYAI 733

  Fly   761 AVPFGAEYRSNLSVAILKLSERGELYDLKQKWW-KNPN-ASCFEEPD-PDATPDMTFEELRGIFY 822
            ||..|...:..:|.|||.|.....|..||:||| .||| .||   || .|.:..::.:.:.|:|.
Worm   734 AVQSGHILKDKISSAILMLLNERRLETLKEKWWTDNPNKVSC---PDSSDESDGISIQNIGGVFI 795

  Fly   823 TLYAGILIAFLIGITEFLVYVQQVAL-----EERLTFKDA 857
            .:.|||.::.:....|:..|.::...     :|.|..|.:
Worm   796 VILAGIALSIVTLAFEYYYYKRKARKAAEKEQEELEMKQS 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	70/382 (18%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	19/113 (17%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	122/407 (30%)
		Lig_chan	554..828	CDD:278489	92/310 (30%)
glr-7	NP_001337310.1	Periplasmic_Binding_Protein_Type_1	<102..>220	CDD:324556	26/147 (18%)
glr-7	NP_001337310.1	PBP2_iGluR_putative	373..767	CDD:270435	122/407 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910