DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIC and nmr-2

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_001256640.1	Gene:	nmr-2 / 180002	WormBaseID:	WBGene00003775	Length:	990	Species:	Caenorhabditis elegans

Alignment Length:	1077	Identity:	224/1077 - (20%)
Similarity:	396/1077 - (36%)	Gaps:	287/1077 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWQRILLLGCMWSAFFMCRSRGQQINIG-------------------AFFYDD----ELELEKEF 42
            :|..:|||    :.||   .:.|.|::|                   |..|..    ....:|.|
Worm     5 IWFILLLL----ATFF---EKNQSIDLGGSRKVQKPKEDPKREDVNIAVVYQHYAGRSKSYDKAF 62

  Fly    43 MTVVNAINGPESEQTMRFYPLIKRLKPED-----GSVTMQEHACDLIDNGVAA------IFGPSS 96
            ..|:..||...:..::|........:..|     |:..::| ..|.:.|.|.:      ||..:|
Worm    63 KEVIRKINDATAVSSLRRLATRYNFQAVDCILPTGTFFVKE-VLDCLCNNVTSNNVALIIFVTAS 126

  Fly    97 K------AASDIVALVCNSTGIPHIEFDISDEG------------IQAEKP-NHQMTLNLYPAQA 142
            :      ||........:.||||.|.::..:.|            ||...| .||       |:|
Worm   127 ETYDSTTAAEQYFLTAASYTGIPIIAWNADNAGFTFENDLGPYRIIQMAPPIEHQ-------ARA 184

  Fly   143 ILSKAYADIVQNFGWRKFTIVYD--ADDARAAARLQDLLQL---REVHNDVVRVRKFHKDDDFRV 202
            :|:     :::.:.|.||.:|..  |.:.|....:::.|:|   :....:::.....:..:|..|
Worm   185 MLA-----LLRRYNWPKFGVVTSEMAGNDRFVTAIREELELFSNKSTKFEMIHFSHMNTKNDTDV 244

  Fly   203 MWKSIRGERRVVLDCEPNM--LVELLNSSTEFGLTGQYNHIFLTNLETYTDHLEELAADNETF-- 263
            ..|        :.|.:.|.  ::.|..::.:.|              |...|.|::....|.:
Worm   245 DLK--------LADVKKNQAKIILLYANAAQAG--------------TIFSHAEKMDMIGEKYLW 287

  Fly   264 --AVNITAARLLVNPDPPPYSLPYGYVTQRDNIVYESSDPPRTLIHDLIHDALQLFAQSWRNASF 326
              ..::...:..|........|...:.|. .|.::...|....||..|   |.:||..:...
Worm   288 IGTQSVKGTQTTVKAPAQAGMLCVNFHTV-SNAMFAPRDDILPLIIQL---APKLFGAALLQ--- 345

  Fly   327 FYPDRM--VVPRITCDFAASGGRTWAMGRYLARLMKGTSGVNNT------------------NFR 371
            ..|:.|  :...::|. :..|...|..|:|:...||......|.                  ..|
Worm   346 LRPNEMFSLKSNVSCK-SEDGDPYWDNGKYIYEHMKAAFVKGNPFHVDDGHDSFFYTFEKTGRLR 409

  Fly   372 TSILQFDEDGQRITFNIEVYDPLDGIGIAIWDPRGQITQLNV---DVK-----------AQKKMI 422
            .||||..        |:..    :..|...|:..|..|...:   ||:           |..|..
Worm   410 NSILQIS--------NLRT----NSKGEKTWEKVGIFTNNELKMADVQWPGEKANPPQGAADKFH 462

  Fly   423 YRVATRIGPPYFSYNETARELNLT----------GNALY----------------QGYAVDLIDA 461
            .:|.|...||:.:.::...:....          |:..|                .||.|||::.
Worm   463 VKVVTLHEPPFIAVSDVDPDTQKCPGNQGSICDWGDVEYTDGAGVKKNRTLLKCCSGYCVDLLNK 527

  Fly   462 IARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFM 526
            :|..:||.|....|.|:::|.  |....|||:|.::::|.|.|.:..|.:...|...:||::||:
Worm   528 LANDIGFTYTLYKVRDEKWGL--KTENGWNGLIADLMHNKADMCVTSLKLNSERARDIDFSLPFL 590

  Fly   527 QLGVSILA-YKSPHVEKTLDAYLAPFGGEVWIWILISVFVMTFLKTIVARIS--KMDWENPHPCN 588
            ..|:||:. .:|..:..|  |:|.||....|:.||       |:...||.||  ..:|.:|:..|
Worm   591 DTGISIIVKIRSGVLSPT--AFLEPFEYSTWVIIL-------FVCIHVAAISIFLFEWVSPYSFN 646

  Fly   589 RD---PEVLENQWRIHNTGWLTVASIMTAGCDI-LPRSPQVRMFEATWWIFAIIIANSYTANLAA 649
            ..   |.  |:::.:..:.||..|::.:|.... :|:|...|:....|..|.:.....|||||||
Worm   647 MQKYPPP--EHKFSLFRSYWLVWATLFSASVSTDVPKSTVSRLMALVWAAFGLTFLAVYTANLAA 709

  Fly   650 FLTSSKMEGSIANLKD------LSAQKKVKFGTIYGGSTYNLLADSNETVYRLAFNLMNNDDPSA 708
            |:.:......::.:.|      ...:...:|||:.||:|:       ||:.|....:......:.
Worm   710 FMITRVQYYDLSGIHDPMLNFPHDQKPPFRFGTVDGGNTH-------ETMKRNWHKMHEYVKHNK 767

  Fly   709 YTKDNLE-GVDRVRKNRGDYMFLMETTTLEY--HREQNCDLRSVGEKFGEKHYAIAVPFGAEYRS 770
            |.:.|:. |::.|:....| .|:.:...|:|  .::.||.|.:||:......|.|..|..:.:.|
Worm   768 YFRMNISAGIEAVKNEELD-AFIYDAVVLDYWAGKDANCALMTVGKWASMTGYGIGFPKNSPHTS 831

  Fly   771 NLSVAILKLSERGELYDLKQKWWKNPNASCFEEPDPDATPD---------MTFEELRGIFYTLYA 826
            .::..:|:..::|:|..|:..|.   ..:|        |||         :..|.....|..|..
Worm   832 LVNHYMLQYQQKGDLERLQNFWL---TGAC--------TPDSHSQTQSAPLGIENFLSAFVLLAG 885

  Fly   827 GILIAFLI-GITEFLVY------------------VQQVALEERLTFKDAFKKEIRFVLCVWNNR 872
            ||:::.:: |...  :|                  :..:|:.:.|||.:|..:     :..|.:|
Worm   886 GIIVSVIVLGFEH--IYCMHLRKPLQKIDPNGWCGIISMAMGKSLTFTEAVDR-----VQEWRSR 943

  Fly   873 KPIVAGT------------------PISSVRTTPRRS 891
            ...:|.|                  |.:.....||||
Worm   944 TQSLASTNSPQLKRRRSANLRPTEEPFNQDLNPPRRS 980

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	82/461 (18%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	19/85 (22%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	103/412 (25%)
		Lig_chan	554..828	CDD:278489	69/297 (23%)
nmr-2	NP_001256640.1	rSAM_ocin_1	<54..>108	CDD:274893	10/54 (19%)
		Periplasmic_Binding_Protein_type1	102..443	CDD:385651	73/395 (18%)
		Periplasmic_Binding_Protein_Type_2	460..860	CDD:389745	105/431 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910