Protein Alignment GluRIIC and nmr-2

DIOPT Version :10

• Sequence 1: NP_608557.4
• Gene: GluRIIC / 33275
• FlyBaseID: FBgn0046113
• Length: 940
• Species: Drosophila melanogaster
• Sequence 2: NP_001256640.1
• Gene: nmr-2 / 180002
• WormBaseID: WBGene00003775
• Length: 990
• Species: Caenorhabditis elegans
• Alignment Length: 1077
• Identity: 224/1077 - (20%)
• Similarity: 396/1077 - (36%)
• Gaps: 287/1077 - (26%)

  Fly     1 MWQRILLLGCMWSAFFMCRSRGQQINIG-------------------AFFYDD----ELELEKEF 42
            :|..:|||    :.||   .:.|.|::|                   |..|..    ....:|.|
 Worm     5 IWFILLLL----ATFF---EKNQSIDLGGSRKVQKPKEDPKREDVNIAVVYQHYAGRSKSYDKAF 62

  Fly    43 MTVVNAINGPESEQTMRFYPLIKRLKPED-----GSVTMQEHACDLIDNGVAA------IFGPSS 96
            ..|:..||...:..::|........:..|     |:..::| ..|.:.|.|.:      ||..:|
 Worm    63 KEVIRKINDATAVSSLRRLATRYNFQAVDCILPTGTFFVKE-VLDCLCNNVTSNNVALIIFVTAS 126

  Fly    97 K------AASDIVALVCNSTGIPHIEFDISDEG------------IQAEKP-NHQMTLNLYPAQA 142
            :      ||........:.||||.|.::..:.|            ||...| .||       |:|
 Worm   127 ETYDSTTAAEQYFLTAASYTGIPIIAWNADNAGFTFENDLGPYRIIQMAPPIEHQ-------ARA 184

  Fly   143 ILSKAYADIVQNFGWRKFTIVYD--ADDARAAARLQDLLQL---REVHNDVVRVRKFHKDDDFRV 202
            :|:     :::.:.|.||.:|..  |.:.|....:::.|:|   :....:::.....:..:|..|
 Worm   185 MLA-----LLRRYNWPKFGVVTSEMAGNDRFVTAIREELELFSNKSTKFEMIHFSHMNTKNDTDV 244

  Fly   203 MWKSIRGERRVVLDCEPNM--LVELLNSSTEFGLTGQYNHIFLTNLETYTDHLEELAADNETF-- 263
            ..|        :.|.:.|.  ::.|..::.:.|              |...|.|::....|.:
 Worm   245 DLK--------LADVKKNQAKIILLYANAAQAG--------------TIFSHAEKMDMIGEKYLW 287

  Fly   264 --AVNITAARLLVNPDPPPYSLPYGYVTQRDNIVYESSDPPRTLIHDLIHDALQLFAQSWRNASF 326
              ..::...:..|........|...:.|. .|.::...|....||..|   |.:||..:...
 Worm   288 IGTQSVKGTQTTVKAPAQAGMLCVNFHTV-SNAMFAPRDDILPLIIQL---APKLFGAALLQ--- 345

  Fly   327 FYPDRM--VVPRITCDFAASGGRTWAMGRYLARLMKGTSGVNNT------------------NFR 371
            ..|:.|  :...::|. :..|...|..|:|:...||......|.                  ..|
 Worm   346 LRPNEMFSLKSNVSCK-SEDGDPYWDNGKYIYEHMKAAFVKGNPFHVDDGHDSFFYTFEKTGRLR 409

  Fly   372 TSILQFDEDGQRITFNIEVYDPLDGIGIAIWDPRGQITQLNV---DVK-----------AQKKMI 422
            .||||..        |:..    :..|...|:..|..|...:   ||:           |..|..
 Worm   410 NSILQIS--------NLRT----NSKGEKTWEKVGIFTNNELKMADVQWPGEKANPPQGAADKFH 462

  Fly   423 YRVATRIGPPYFSYNETARELNLT----------GNALY----------------QGYAVDLIDA 461
            .:|.|...||:.:.::...:....          |:..|                .||.|||::.
 Worm   463 VKVVTLHEPPFIAVSDVDPDTQKCPGNQGSICDWGDVEYTDGAGVKKNRTLLKCCSGYCVDLLNK 527

  Fly   462 IARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFM 526
            :|..:||.|....|.|:::|.  |....|||:|.::::|.|.|.:..|.:...|...:||::||:
 Worm   528 LANDIGFTYTLYKVRDEKWGL--KTENGWNGLIADLMHNKADMCVTSLKLNSERARDIDFSLPFL 590

  Fly   527 QLGVSILA-YKSPHVEKTLDAYLAPFGGEVWIWILISVFVMTFLKTIVARIS--KMDWENPHPCN 588
            ..|:||:. .:|..:..|  |:|.||....|:.||       |:...||.||  ..:|.:|:..|
 Worm   591 DTGISIIVKIRSGVLSPT--AFLEPFEYSTWVIIL-------FVCIHVAAISIFLFEWVSPYSFN 646

  Fly   589 RD---PEVLENQWRIHNTGWLTVASIMTAGCDI-LPRSPQVRMFEATWWIFAIIIANSYTANLAA 649
            ..   |.  |:::.:..:.||..|::.:|.... :|:|...|:....|..|.:.....|||||||
 Worm   647 MQKYPPP--EHKFSLFRSYWLVWATLFSASVSTDVPKSTVSRLMALVWAAFGLTFLAVYTANLAA 709

  Fly   650 FLTSSKMEGSIANLKD------LSAQKKVKFGTIYGGSTYNLLADSNETVYRLAFNLMNNDDPSA 708
            |:.:......::.:.|      ...:...:|||:.||:|:       ||:.|....:......:.
 Worm   710 FMITRVQYYDLSGIHDPMLNFPHDQKPPFRFGTVDGGNTH-------ETMKRNWHKMHEYVKHNK 767

  Fly   709 YTKDNLE-GVDRVRKNRGDYMFLMETTTLEY--HREQNCDLRSVGEKFGEKHYAIAVPFGAEYRS 770
            |.:.|:. |::.|:....| .|:.:...|:|  .::.||.|.:||:......|.|..|..:.:.|
 Worm   768 YFRMNISAGIEAVKNEELD-AFIYDAVVLDYWAGKDANCALMTVGKWASMTGYGIGFPKNSPHTS 831

  Fly   771 NLSVAILKLSERGELYDLKQKWWKNPNASCFEEPDPDATPD---------MTFEELRGIFYTLYA 826
            .::..:|:..::|:|..|:..|.   ..:|        |||         :..|.....|..|..
 Worm   832 LVNHYMLQYQQKGDLERLQNFWL---TGAC--------TPDSHSQTQSAPLGIENFLSAFVLLAG 885

  Fly   827 GILIAFLI-GITEFLVY------------------VQQVALEERLTFKDAFKKEIRFVLCVWNNR 872
            ||:::.:: |...  :|                  :..:|:.:.|||.:|..:     :..|.:|
 Worm   886 GIIVSVIVLGFEH--IYCMHLRKPLQKIDPNGWCGIISMAMGKSLTFTEAVDR-----VQEWRSR 943

  Fly   873 KPIVAGT------------------PISSVRTTPRRS 891
            ...:|.|                  |.:.....||||
 Worm   944 TQSLASTNSPQLKRRRSANLRPTEEPFNQDLNPPRRS 980

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	Periplasmic_Binding_Protein_type1	26..409	CDD:471960	83/466 (18%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	103/412 (25%)
		Lig_chan	554..827	CDD:459656	69/296 (23%)
nmr-2	NP_001256640.1	Periplasmic_Binding_Protein_type1	102..443	CDD:471960	73/395 (18%)
		Periplasmic_Binding_Protein_Type_2	460..860	CDD:473866	105/431 (24%)