Protein Alignment GluRIIC and glr-5

DIOPT Version :10

• Sequence 1: NP_608557.4
• Gene: GluRIIC / 33275
• FlyBaseID: FBgn0046113
• Length: 940
• Species: Drosophila melanogaster
• Sequence 2: NP_505244.1
• Gene: glr-5 / 179251
• WormBaseID: WBGene00001616
• Length: 932
• Species: Caenorhabditis elegans
• Alignment Length: 905
• Identity: 240/905 - (26%)
• Similarity: 413/905 - (45%)
• Gaps: 142/905 - (15%)

  Fly    35 ELELEKEFMTVVNAINGPESEQTMRFYPLIKRLKPEDGSVTMQEHACDLID-NGVAAIFGPSSKA 98
            :::|..|::.|::            .|..||:             ||.::: :.:.|:.|.|..|
 Worm    58 DIDLVIEYIDVLD------------HYDAIKK-------------ACKMLEKDHIVALLGGSHAA 97

  Fly    99 ASDIVALVCNSTGIPHIEF--DI-SDEGIQAEKPNHQMTLNLYPAQAILSKAYADIVQNFGWRKF 160
            .:..:..:.:...||.:..  |: :|.|        :..::.:| :..|.:|..|:..::.|.:.
 Worm    98 LNAQLERITDDLDIPFLTAIDDLRTDMG--------KSKIDFWP-RPQLFEAVVDMFTHWRWNRI 153

  Fly   161 TIVYDADDARAAARLQDLLQLRE----------VHN-DVVRVRKFHKD-DDFRVMWKSIRGE-RR 212
            .:||:.|:  ...||:.||:..|          ||: |.::..:..|: ::.|::.|....| .|
 Worm   154 VLVYEGDE--RIRRLEQLLESEEYASIRFYLIKVHDGDYMKAARQVKELEECRLLHKKDCSEFSR 216

  Fly   213 VVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNLETYTDHLEELAADNETFAVN---------IT 268
            :::|..|......|.:|.:.||....:...|||:|..|       .|.|.|..|         :.
 Worm   217 LLVDMNPEHTYTFLLASLQMGLIELKHWFLLTNMELST-------MDMELFRYNHARFISPYPVD 274

  Fly   269 AARLLVNPDPPPYSLPYGYVTQRDNIVYESSDPPRTLIHDLIHDALQLFAQSWRNASFFYPDRMV 333
            :..|..|.|...:|....::|::..:..::|...:.:......||:..||..:...| .:.....
 Worm   275 STFLTENRDAFNFSHFKEHITEKWAMKTDNSRNLKMMEAVFTFDAVYAFANVFNELS-SHMQMND 338

  Fly   334 VPRITCDFAASGGRTWAMGRYL---------------ARLMKGTSGVNNTNFRTSILQFDEDGQR 383
            ||:..|..::...|.:..||.|               .|.:.|....:|.:.|..:|.:  .|:
 Worm   339 VPQTLCRKSSRNSRKYQHGRSLIDNIVHNDLHGLSGDLRRLNGHPLKSNFSMRIQLLGY--SGR- 400

  Fly   384 ITFNIEVYDPLDGIGIAIWDPRGQI-----------TQLNVDVKAQKKMIYRVATRIGPPYFSYN 437
                      ||.||  .|:|...:           .|.||.|..:.|..:||.|.:..||....
 Worm   401 ----------LDDIG--FWEPATNVHVNMSGDSKAQLQRNVQVSDELKPHFRVTTIMERPYVMLK 453

  Fly   438 ETARELNLTGNALYQGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDA 502
            :...||:  .|:.::|:.:||:..:::.:||.|....|.|.:||........|:|::|||:..:|
 Worm   454 KNHYELD--ANSKFEGFCIDLLAELSKDLGFTYTIHAVKDGKYGNDKYGNGSWDGMMGEILRGEA 516

  Fly   503 HMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEK-TLDAYLAPFGGEVWIWILISVFVM 566
            .|.:..||:...|..|||||.||:.||:||| ||.|..:: .|.::|.|...::|..|..|:..:
 Worm   517 EMAVAPLTVNYRRSEAVDFTKPFLSLGISIL-YKVPDDQQPDLFSFLNPLSWQIWTAIATSIITV 580

  Fly   567 TFLKTIVARISKMDW---------ENPHPC-----NRD-PEVLENQWRIHNTGWLTVASIMTAGC 616
            |.....||.::..:|         ..|||.     |:: |.|:.|.:...||.|..:::::..||
 Worm   581 TLGMYFVANVTPYEWNLNFSCCTAHEPHPAAAFATNQEAPIVMSNNYSFWNTVWYVLSTMLKGGC 645

  Fly   617 DILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLSAQKKVKFGTIYGGS 681
            |..||:...|:...|||:|.::|.::|||||||.||.|:....|.||.||:.|..:.:|||.|||
 Worm   646 DFGPRAVSTRLLGGTWWVFYLVIISAYTANLAAVLTVSRPYIPIKNLDDLANQTTISYGTIRGGS 710

  Fly   682 TYNLLADSNETVYRLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFLMETTTLEYHREQNCDL 746
            |.....:|....:...:..|.:.|  .:...|.:||:|....  :|.:|||:|:|||..:|||:|
 Worm   711 TMQFFQESRIAAHVKMWQYMKDKD--VFVTSNGKGVERALSM--NYAYLMESTSLEYETQQNCNL 771

  Fly   747 RSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNPNASCFE-----EPDP 806
            ..:|...|.|.|.||:...:|:...:|..||..::||.:...|.|||::..|:|..     :.|.
 Worm   772 TQIGGVLGSKGYGIALAKKSEWTDRISRQILLYAKRGIIEMKKTKWWRSKGAACASTASAVKHDR 836

  Fly   807 DATPDMTFEELRGIFYTLYAGILIAFLIGITEFLVYVQQVALEERLTFKDAFKKEIRFVL 866
            .|   ::...:.|:|.||..||::|.::.|.|.:.....:|.:|...|.:....|:||.|
 Worm   837 FA---LSMYNVAGLFITLGVGIVLAAIVVIFELIHRCHHIAKKEGKPFLEELLYELRFAL 893

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	Periplasmic_Binding_Protein_type1	26..409	CDD:471960	83/425 (20%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	131/386 (34%)
		Lig_chan	554..827	CDD:459656	94/292 (32%)
glr-5	NP_505244.1	PBP1_iGluR_non_NMDA-like	26..417	CDD:380591	83/417 (20%)
		PBP2_iGluR_Kainate	438..819	CDD:270432	131/387 (34%)
		Lig_chan	566..854	CDD:459656	94/294 (32%)