DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIC and glr-1

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_498887.2	Gene:	glr-1 / 176204	WormBaseID:	WBGene00001612	Length:	962	Species:	Caenorhabditis elegans

Alignment Length:	857	Identity:	240/857 - (28%)
Similarity:	391/857 - (45%)	Gaps:	137/857 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 EDG---SVTMQEHACDLIDNGVAAIFGPSSKAASDIVALVCNSTGIPHIEFD-ISDEGIQAEKPN 130
            |:|   |..|....||.:..|..|:.........:.:..|.::..:|.:... :|::..|.::..
Worm    74 EEGAAVSWNMVNAVCDELKEGAMALLSSVDGKGREGIRGVSDALEMPLVSLTALSNDDHQQQQFG 138

  Fly   131 HQMTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQ-LREVHNDVVRVRKF 194
            :...:::.|.   :|:..||.:.:.||.:..::  .|...|:..|..|.: ||...|..|:...|
Worm   139 NLFEVSVRPP---ISELLADFIVHKGWGEVLVL--IDPVHASLHLPSLWRHLRTRTNTSVKASMF 198

  Fly   195 HKDDD------FRVMWKSIRGE--RRVVLDC-EPNMLVELLNS--STEFGLTGQYN-HIFLTNLE 247
            ....|      :.:.:..:|..  .|:::|| .|..|.:||.:  |.:|   .|.| |..|.|.:
Worm   199 DLPADEKQFEAYLMQFNMMRNNETNRILIDCASPKRLKKLLINIRSAQF---NQANYHYVLANYD 260

  Fly   248 TYTDHLEELAADNETFA---VNITAARLLVNPDPPPY-SLPYGYVTQR-----DNIVYESSDPPR 303
            .       |..|.|.|.   :||:... ::|.|...| ||.....|..     |::..|::
Worm   261 F-------LPYDQEMFQNGNINISGFN-IINKDGREYWSLKKHLKTSSSLGGGDDVSVEAA---- 313

  Fly   304 TLIHDLIHDAL---------------QLFAQSWRNASFFYPDRMVVPRITCDFAASGGRTWAMGR 353
                 :.|||:               .||..::|:..||   ....|.|.||..:.....   .|
Worm   314 -----VGHDAMLVTWHGFAKCLQANDSLFHGTFRHRRFF---NRGFPGIYCDPLSDRSHP---NR 367

  Fly   354 YLARLMKG-TSGVNNTNFR--------TSILQFDEDGQRITFNIEVYDPLDGI------------ 397
            ..:....| |.||...|.:        |..::||..|.|..|::.:.|.:...
Worm   368 PFSSFEHGKTIGVAFRNMKIGHKEGTLTGNIEFDRFGNRKNFDVSIVDLVSNTKATFNSKEVLAW 432

  Fly   398 --GIAIWDPR--GQITQLNVDVKAQKKMIYRVATRIGPPYFSYNETAREL-NLT---GNALYQGY 454
              |:..:..|  .|.::.:.:.....::|  |.|.:..|:........|: |||   ||..::|:
Worm   433 RQGVGFFSNRTVAQHSRKSQNDHKDNQVI--VLTNLVAPFVMIKRECLEMANLTECQGNNKFEGF 495

  Fly   455 AVDLIDAIARHV-GFEYVFVPVADQQYGKLDKE--TKQ----WNGIIGEIINNDAHMGICDLTIT 512
            .:||:..:|..: .|.|..         ||..:  :||    |:|:|||:::..||..:..|||.
Worm   496 CIDLLKLLADKIEEFNYEI---------KLGTKAGSKQADGSWDGMIGELLSGRAHAVVASLTIN 551

  Fly   513 QARKTAVDFTVPFMQLGVSILAYKSPHVEKTLDAYLAPFGGEVWIWIL---ISVFVMTFLKTIVA 574
            |.|:..|||:.|||..|:||:..|....|.::.:::.|...|:|::|:   |.|.|:.||   |:
Worm   552 QERERVVDFSKPFMTTGISIMIKKPDKQEFSVFSFMQPLSTEIWMYIIFAYIGVSVVIFL---VS 613

  Fly   575 RISKMDWENPHPCNRDPEVLENQWRIHNTGWLTVASIMTAGCDILPRSPQVRMFEATWWIFAIII 639
            |.|..:| .....:|....:.|.:.::|..|.|:|:.|..|.||||||...|:..:.||.|.:||
Worm   614 RFSPYEW-RVEETSRGGFTISNDFSVYNCLWFTLAAFMQQGTDILPRSISGRIASSAWWFFTMII 677

  Fly   640 ANSYTANLAAFLTSSKMEGSIANLKDLSAQKKVKFGTIYGGSTYNLLADSNETVYRLAFNLMNND 704
            .:|||||||||||..||:..|.:::||:.|.|:|:|...||||.:....|:..:|:..:..|.:.
Worm   678 VSSYTANLAAFLTLEKMQAPIESVEDLAKQSKIKYGIQGGGSTASFFKYSSVQIYQRMWRYMESQ 742

  Fly   705 DPSAYTKDNLEGVDRVRKNRGDYMFLMETTTLEYHREQN-CDLRSVGEKFGEKHYAIAVPFGAEY 768
            .|..:.....||::|||.::|.|.||:|.|..||...:. ||...||.......|.||.|||:::
Worm   743 VPPVFVASYAEGIERVRSHKGRYAFLLEATANEYENTRKPCDTMKVGANLNSIGYGIATPFGSDW 807

  Fly   769 RSNLSVAILKLSERGELYDLKQKWWKNPNASCFEEPDPDATPD-----MTFEELRGIFYTLYAGI 828
            :.::::|||.|.|||||..|:.|||.: ...|    |...|.|     :...::.||||.|..|:
Worm   808 KDHINLAILALQERGELKKLENKWWYD-RGQC----DAGITVDGSSASLNLSKVAGIFYILMGGM 867

  Fly   829 LIAFLIGITEFL 840
            :|:.|..:.|||
Worm   868 VISMLAALGEFL 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	83/397 (21%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	20/105 (19%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	138/385 (36%)
		Lig_chan	554..828	CDD:278489	105/282 (37%)
glr-1	NP_498887.2	PBP1_iGluR_AMPA	10..439	CDD:107375	83/395 (21%)
		ANF_receptor	44..417	CDD:279440	82/373 (22%)
		Periplasmic_Binding_Protein_Type_2	457..832	CDD:304360	138/389 (35%)
		Lig_chan	593..867	CDD:278489	105/282 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020