DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIC and glr-2

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_001021114.1	Gene:	glr-2 / 175999	WormBaseID:	WBGene00001613	Length:	977	Species:	Caenorhabditis elegans

Alignment Length:	938	Identity:	241/938 - (25%)
Similarity:	400/938 - (42%)	Gaps:	155/938 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 CDLIDNGVAAIFGPSSKAASDIVALVCNSTGIPHIEFDIS-DEGIQAEKPNHQMTLNLYP-AQAI 143
            ||.:..|...:...::.....|...:.|...:|.|:::.| .|.|.....|:.|..::.| |:.:
Worm    87 CDEMKLGYMLMLAGTNFKNYGIYEDIANHMKMPLIDWEPSKSENIGKTTENNPMIFSVAPSAEQL 151

  Fly   144 LSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQLRE--------VHNDVVR---------V 191
            |    .|.:|..|||....::|..:|....|.. ...|.|        |.|.|..         :
Worm   152 L----IDYIQYKGWRDVVYIHDGKNADRTLRTM-FSYLHEKSPKYQLFVDNYVAPSDEEMFKEFL 211

  Fly   192 RKFHKDDDFRVMWKSIRGERRVVLDCEPNMLVEL---------LNSSTEFGLTGQYNHIFLTNLE 247
            .:||:....:...||......:......|::|:|         |.:..|..|..:..|...:|.:
Worm   212 NEFHRRISTQHTLKSNDSSEEIDEPIPVNVIVDLEGSYRTRAFLRALEESVLVKKEYHYVFSNFD 276

  Fly   248 TYTDHLEELAADNETFA-VNITAARL-------LVNPDPPPYSLPYGYVTQRDNIVYESSDPPRT 304
                 ::|.......|: :|||..|:       .:......:.:..|..:..|:|...::
Worm   277 -----VDETDLSGFHFSLINITIFRIFDKNNKKFLKTRAEFHDVYRGGFSNTDSIPTAAA----- 331

  Fly   305 LIHDLI---HDALQ---------LFAQSWRNASFFYPDRMVVPRITC----DFAASGG-RTWAMG 352
            ..||.|   ..|||         :|.:|:.....|...|   ..:.|    |...|.. .|:..|
Worm   332 FAHDAILVAGKALQIAMNEHGKGIFDKSFVRHQLFNRGR---KGLYCRPHEDQTESRQFETFEHG 393

  Fly   353 RYLARLMKGTSGVNNTNFRTSILQFDE-DGQRITFNIEVYDPLDGIGI--AIWD----PRGQ--- 407
            :.:|..:|.....:.....|..:|||: .|:|..|:.|:.:...|:..  :||:    ..|:
Worm   394 KKIAEAIKKVVLTDKDGTLTGRIQFDKVTGKRTNFSAEIVEIKPGVNSLNSIWERFQWAEGEGFL 458

  Fly   408 ------ITQLNVDVKAQKKMI---------YRVATRIGPPYFSY-NETARELNLTGNALYQGYAV 456
                  :.:...|....:|.|         :.|.|.:..|:... .....|..|.||..::||.:
Worm   459 LGGERYVQEKKKDSSQTRKGILPSKPWQLRFNVVTVLVKPFVMLKRRNPGEPELKGNDRFEGYCI 523

  Fly   457 DLIDAIARHV-GFEY-VFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAV 519
            ||::.:|::: |||| ||:...: :||....: ..|:|:||.::|..|.:.:..|||||.|:.||
Worm   524 DLLNLLAKNITGFEYDVFISDGN-KYGSRQAD-GSWDGMIGYLLNETADVAVAPLTITQERERAV 586

  Fly   520 DFTVPFMQLGVSILAYKSPHVEKTLDAYLAPFGGEVWIWILISVFVMTFLKTIVARISKMDWENP 584
            ||:.|||..|:||:..|....|..:.:::.|.|..:||:.|.|.|.::....:|:      |.:|
Worm   587 DFSKPFMTTGISIMIKKPEKQEFNIFSFMEPLGMTIWIFTLSSYFGVSLTIFLVS------WFSP 645

  Fly   585 H----PCNRDPEVLENQWRIHNTGWLTVASIMTAGCDILPRSPQVRMFEATWWIFAIIIANSYTA 645
            :    ...|....:.|::.::|:.|.|:|:.|..|.|||||:...|:..:.||.|.:||.:||||
Worm   646 YEKRIEFKRGEFTVTNEFTLYNSLWFTLAAFMQQGTDILPRAVSGRIASSCWWFFTLIIVSSYTA 710

  Fly   646 NLAAFLTSSKMEGSIANLKDLSAQKKVKFGTIYGGSTYNLLADSNETVYRLAFNLM--------- 701
            |||||||..:|...|.:::||:.|.|:.:|...||||.....||...:|:..:|.|
Worm   711 NLAAFLTLERMTPPIESVEDLANQNKILYGVNEGGSTAAFFEDSIVPLYKKMWNFMVSTTQKQIE 775

  Fly   702 -------NNDDPSAYTKDNLEGVDRVRKNRGDYMFLMETTTLEYHR-EQNCDLRSVGEKFGEKHY 758
                   |:.....:.....:|:::||.::|.|.||:|.||..|.. .:.||...||:......|
Worm   776 LEKQSITNSTSNRIFVSSYADGIEKVRTSKGKYAFLLEETTNNYESGRRPCDTMKVGQNLNTLGY 840

  Fly   759 AIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNPNASCFEEPDPDATPDMTFEELRGIFYT 823
            .||...|...|.:|::|||.|||:|||..|:.|||.:.........|...:..:...::.||||.
Worm   841 GIATKIGNPLRVSLNLAILYLSEKGELKKLENKWWYDRGQCDTGTSDGGTSSSLNLSKVAGIFYI 905

  Fly   824 LYAGILIAFLIGITEFLVYVQQVALEERLTFKDAFKKEIRFVLCVWNNR----KPIVAGTPISSV 884
            |.||::::....:.|||....          |:..:||        .||    :|:..|     :
Worm   906 LLAGMVLSMCTALVEFLFRKN----------KENREKE--------RNRMRSSRPLKPG-----I 947

  Fly   885 RTTPRRSLDKSLDRTPKSSRRVVIGRSS 912
            ..:..|:..|.|......|..|...||:
Worm   948 LASCERAKQKQLQNRRTKSEEVSTPRST 975

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	77/382 (20%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	20/100 (20%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	134/394 (34%)
		Lig_chan	554..828	CDD:278489	96/294 (33%)
glr-2	NP_001021114.1	Periplasmic_Binding_Protein_Type_1	7..453	CDD:299141	77/383 (20%)
		Periplasmic_Binding_Protein_Type_2	491..875	CDD:304360	133/391 (34%)
		Lig_chan	621..910	CDD:278489	96/294 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020