Protein Alignment GluRIIC and nmr-1

DIOPT Version :10

• Sequence 1: NP_608557.4
• Gene: GluRIIC / 33275
• FlyBaseID: FBgn0046113
• Length: 940
• Species: Drosophila melanogaster
• Sequence 2: NP_495033.2
• Gene: nmr-1 / 173929
• WormBaseID: WBGene00003774
• Length: 1025
• Species: Caenorhabditis elegans
• Alignment Length: 985
• Identity: 212/985 - (21%)
• Similarity: 372/985 - (37%)
• Gaps: 258/985 - (26%)

  Fly    91 IFGPSS-KAASDIV--ALVCNSTGIPHIEFDISDEGIQAEKPNHQMTLNLYPAQAILSKAYADIV 152
            :||.:| ...:|.:  |.|...:|...:|  ::.:.:.::..||.:...::......|..:.|:|
 Worm    50 VFGSTSYHLGNDTISAAFVDAKSGDNRLE--LTQDIVCSQMLNHSLASVIFSPLLTSSSRFIDLV 112

  Fly   153 QNFGWR-KF-------TIVYDADDA---------RAAARLQD--------LLQLREVHNDVVRVR 192
            .:..:. .|       .:|.||:.:         |..|.|.|        ||.|:.....|:.|:
 Worm   113 TSSAYTLSFYKLPVVGVMVRDAEFSKKNIYPTFVRPTAPLSDEAFVFLHMLLSLKYRQVVVLSVK 177

  Fly   193 KFHKDDDFRVMWKSIRGERRVV----LDCEPNMLVELLNSSTEFGLTGQYNHIFLTNLETYTDHL 253
            :....|.|...::..|.|.:::    ::.|.|   |.||                   :|..:..
 Worm   178 RDINADQFVEEFEKRRVEFKIIVQRYIEVELN---ENLN-------------------DTLAESF 220

  Fly   254 EELAAD-NETFAVNITAARLLVNPDPPPYSLPYGYVTQRDN--IVYESSDPPRTL---------- 305
            ||:.:: ...||....|.|:..|.         |.:|.:..  ||.||:.....:
 Worm   221 EEVTSNIIVLFAKKDDAVRIFANA---------GDLTGKGKVWIVSESAGEAHNVPNGSLGCRLG 276

  Fly   306 --IHDLIHDALQLFAQSWRNASFFYPDRM-VVPRITCDFAASGGRTWAMGRYLARLMK--GTSGV 365
              ...::.|:..:...:..  :.|...:: :.|.:.|| ..|....|...:..|.|.:  |||
 Worm   277 QTAFSVLRDSFSILKSAME--TIFRESKIDIFPPVECD-RDSVDAEWNSLQAPALLNEICGTS-- 336

  Fly   366 NNTNFRTSILQFDEDGQRITFNIEVYDPLD------GIGIAIWDPRGQITQLNVD---------- 414
                  ||.:.|::..:||  .:| ||.::      .:|..:    |.|.:|:.|
 Worm   337 ------TSRVHFNDKCERI--GVE-YDIINFHMERKQVGNMV----GDILRLDEDSIEWAGGTKP 388

  Fly   415 --VKAQKKMIYRVATRIGPPYF------SYNETAR-----------------------ELNLTGN 448
              :...|.:  ||.|...||:.      |.::.|.                       .|.|..:
 Worm   389 LEISLPKHL--RVVTVADPPFVYTTPIGSPSQCAELGNTVVEWSIFDKIVVSGPWYSCPLTLENS 451

  Fly   449 ALY---QGYAVDLIDAIA-----RHVGFEYVFVPVADQQYGKLD-KETK--QWNGIIGEIINNDA 502
            ..|   .|.|:||:..::     ..:...:.|....::.||.:. .||.  ..:|:|||:..:.|
 Worm   452 TEYFCCAGLAIDLLSNLSLPEANNSIDTSFTFSLHLNESYGVVQASETTGITISGVIGELDGDTA 516

  Fly   503 HMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKTLDAYLAPFGGEVWIWILISVFVMT 567
            .|.|..:||...|:..||||.|::..|:.||....|. :..:.::|.|....:|..:.|||.::.
 Worm   517 DMAIGGITINPERERIVDFTEPWLYHGIRILEKNIPR-DSPMQSFLQPLQSSLWTALFISVILVG 580

  Fly   568 F------LKTIVARISKMDWENPHPCNRDPEVL------ENQWRIHNTG---WLTVASIMTAG-C 616
            .      .|:...|..:.|.|......::.|:.      ||.    |.|   |.....::.:| .
 Worm   581 LAIYCLDFKSPFERFYQADKEMEQDLKKEFELWIGKDADENV----NFGEAMWFVWGVLLNSGVS 641

  Fly   617 DILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKD---LSAQKKVKFGTIY 678
            :..|||...|:....|..|.:|:..||||||||||...:.|..:..:.|   .:......|||:.
 Worm   642 EKTPRSCSARVLGIVWCGFCMIMVASYTANLAAFLVLDQPEKGLTGVTDPRLRNPSANFSFGTVL 706

  Fly   679 GGSTYNLLADSNETVYRLAFNLMNNDDPSAYTKDNLEGVDRVRK-----------------NRGD 726
                       |..||:             |.|.::|.....||                 |...
 Worm   707 -----------NSNVYQ-------------YFKRHVELSSMFRKMEPHNVRRASEAVHSLLNGSL 747

  Fly   727 YMFLMETTTLEYHREQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQK 791
            ..|:.::|.||:...::|:||:.|..||...|.|.:...:.:..:::.|||::||.|.:..|.||
 Worm   748 DAFIWDSTRLEFEAARHCELRTRGSLFGRSAYGIGLQKNSPWTPHITSAILRMSESGVMEKLDQK 812

  Fly   792 WWKNPNASCFEEPDPDATPDMTFEELRGIFYTLYAGILIAFLIGITEFLVYVQQVALEERLTFKD 856
            |......:|..|.. .:...:....::.||..:.:|:    .:||  ||.:| :|:...||..|.
 Worm   813 WIDRGGPNCVVEAH-KSPARLGLVNMKDIFILVSSGV----ALGI--FLSFV-EVSYGRRLADKG 869

  Fly   857 AFKKEIRFVLCVWNNRKPIVAGTPISSVRTTPRRSLDKSLDRTPKSSRRVVIGR--------SSE 913
            ..::.:......|::   :..|.     :..|.| |..:||       |:::.|        |.:
 Worm   870 RRRRIVTRYFQKWHD---LTLGK-----KRRPYR-LKYNLD-------RMIVRRGFSGLERCSFQ 918

  Fly   914 EMREMAQGSG 923
            |:||..|..|
 Worm   919 ELRERRQIRG 928

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	Periplasmic_Binding_Protein_type1	26..409	CDD:471960	71/373 (19%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	108/446 (24%)
		Lig_chan	554..827	CDD:459656	72/308 (23%)
nmr-1	NP_495033.2	Periplasmic_Binding_Protein_type1	19..384	CDD:471960	74/384 (19%)
		PBP2_iGluR_NMDA_Nr1	394..822	CDD:270437	109/458 (24%)
		Lig_chan	566..844	CDD:459656	72/306 (24%)
		LITAF	949..1017	CDD:197841