Protein Alignment GluRIIC and glr-3

DIOPT Version :10

• Sequence 1: NP_608557.4
• Gene: GluRIIC / 33275
• FlyBaseID: FBgn0046113
• Length: 940
• Species: Drosophila melanogaster
• Sequence 2: NP_492017.3
• Gene: glr-3 / 172449
• WormBaseID: WBGene00001614
• Length: 836
• Species: Caenorhabditis elegans
• Alignment Length: 807
• Identity: 224/807 - (27%)
• Similarity: 374/807 - (46%)
• Gaps: 125/807 - (15%)

  Fly    81 CDLIDNGVAAIFGPSS----KAASDIVALVCNSTGIPHIEFDISDEGIQAEKPNHQMTLNLYPAQ 141
            |:.:..|.:||..|..    .||:.||..:.::|.:|.:...:|        |..:.:.:|:|..
 Worm    76 CNCLILGASAIILPEQYDGHLAAAAIVQSIADNTNVPCVSLHLS--------PPTRPSTHLHPHL 132

  Fly   142 AILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQLREVHNDVVRVRKFHKD--------- 197
            ...|.|.|..::...|:...:|::..|        :||::    .|::....|..|
 Worm   133 NAKSLAVAAFIKREKWKDVVVVFEEPD--------ELLEI----TDMITAGHFDPDSFSSQLVRL 185

  Fly   198 ---DDFRVMWKSIRGE---RRVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNLETYTDHLEEL 256
               ||:....|.|:.:   .|:|::......:..|..:....:.|...|..:.:::..|..::.:
 Worm   186 KHGDDYGNELKHIKNKLDRYRIVINIPLQKALHFLEQAANMSMCGVLYHYVVMDMDLVTVDIDSI 250

  Fly   257 AADNETFAVNITAARLL-VNPDPPPYSLPYGYVTQ-RDNIVYESS------DPPRTLIHDLIHDA 313
            ....:   .|||:..:. ||.:         |:.. |..||::||      ..|.|.  .:..|.
 Worm   251 RGIED---CNITSFGVHDVNSE---------YIEDIRQEIVHKSSIRLPKKGVPYTT--SIWIDT 301

  Fly   314 LQLFAQSWRNASFFYPDRMVVPRITCDFAASGGRTWAMG-----RYLARLMKGTSGVNNTNFRTS 373
            |:|..:|.::...:...|       |      |.:|..|     |:....:.|.||
 Worm   302 LRLLIRSMKSIQIWDEPR-------C------GSSWKSGSDIKKRFFENPLAGISG--------- 344

  Fly   374 ILQFDEDGQRITFNIEVY-DPLDGIGIAIWDPR-------------GQITQLNVDVKAQKKMIYR 424
            .|.:...|:|..:.:.|| ..|.....|.|..|             ....:|.::.|..|..:|.
 Worm   345 DLHWAPSGERSNYTLHVYRRTLSFQKFAEWSSRTRRIASSEAVVIANSSEKLTLEGKHLKISVYL 409

  Fly   425 VATRIGPPYFSYNETARELNLTGNALYQGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQ 489
            .|     |:         :.:|.|..|:||.:||:..||..:.|.|....|.|..||..:...|
 Worm   410 EA-----PF---------VMITSNGSYEGYCIDLLHKIANILKFTYTIQKVRDNAYGSKESNGK- 459

  Fly   490 WNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHV-EKTLDAYLAPFGG 553
            |:|::||:...||.:.:..|||:..|...:|||||:|.||:||| :|.|.: :.....::.|...
 Worm   460 WSGMVGELQRGDADLAVASLTISYGRSEVIDFTVPYMHLGISIL-FKKPRIRDSDWFKFMDPLST 523

  Fly   554 EVWIWILISVFVMTFLKTIVARISKMDWENPHPCNRDPEVLENQWRIHNTGWLTVASIMTAGCDI 618
            :|||....|.||::....|:|:||..:.......|...:.::||:.:.|:.|.||.|:|..|.::
 Worm   524 QVWIMTFASYFVVSVAIWIIAKISPYEQFERDEDNGQYKPVDNQFSLRNSFWFTVCSLMQQGSEL 588

  Fly   619 LPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLSAQKKVKFGTIYGGSTY 683
            .||:...|:....||.||:|:.:||||||||.||:.:||..|.|..||:||.|:|:||:..|||.
 Worm   589 CPRAASTRLLTGIWWFFALILISSYTANLAAVLTTRRMETPIENADDLAAQTKIKYGTLGRGSTM 653

  Fly   684 NLLADSNETVYRLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFLMETTTLEYHREQNCDLRS 748
            :...:|....|...:.||:: .|..:.:.:.||:.||:.:  ||.:|||::.|||..|::|:|..
 Worm   654 SFFNESKIETYERMWQLMSS-SPGLFVQSSKEGIARVKSS--DYAYLMESSMLEYAVERDCELMQ 715

  Fly   749 VGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNPNASCFEEPDPDATPDMT 813
            :|....:|.|.|.:|.|:.||..:|.|||:|.|:.||.:||:||||:.:..| |:|......|
 Worm   716 IGGLIDQKGYGIGLPKGSPYRELISTAILRLQEKTELTELKEKWWKDKSVVC-EQPKRKDQDD-- 777

  Fly   814 FEELRGIFYTLYAGILIAFLIGITEFL 840
            .|.:.|||..|..|:::..::.|.|.:
 Worm   778 GESIGGIFIILVVGLVLTAVLVIFELI 804

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	Periplasmic_Binding_Protein_type1	26..409	CDD:471960	71/373 (19%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	136/371 (37%)
		Lig_chan	554..827	CDD:459656	104/272 (38%)
glr-3	NP_492017.3	PBP1_iGluR_non_NMDA-like	21..385	CDD:380591	71/364 (20%)
		Periplasmic_Binding_Protein_Type_2	401..761	CDD:473866	138/378 (37%)