DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIC and Grin3b

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_579842.2	Gene:	Grin3b / 170796	RGDID:	621705	Length:	1002	Species:	Rattus norvegicus

Alignment Length:	907	Identity:	202/907 - (22%)
Similarity:	339/907 - (37%)	Gaps:	243/907 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 VAAIFGPSSKAASDIVALVCNSTGIPHIEFDISDEGIQAEKPNHQ-------MTLNLYPAQAILS 145
            :||:...:..|.:.::|.:  :|..|.:..::|.|.:....|...       :...|.|...:.|
  Rat    41 LAALLPRAPAARARVLAAL--ATPAPRLPHNLSLELVAVASPTRDPASLARGLCQVLAPPGVVAS 103

  Fly   146 KAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQL-----------REVHNDVVRVRKFHKDDD 199
            .|:                  .:||...||...|..           |||...:.....||...|
  Rat   104 IAF------------------PEARPELRLLQFLAAATETPVVSVLRREVRTALGAPTPFHLQLD 150

  Fly   200 FRVMWKSIRGERRVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLT--------NLET-YTDH--- 252
                |.|   ....:||    :||.|:.:..       :..|.|.        :|.| :|:|
  Rat   151 ----WAS---PLETILD----VLVSLVRAHA-------WEDIALVLCRVRDPGSLVTLWTNHASQ 197

  Fly   253 -------LEELAADNETFAVNITAARLLVNPDPP-PYSLPYGYVTQRDNIVYESSDP-PRTLI-- 306
                   |..|.:.|::....:.....|.....| |.::..|..|.|.:.|.|::.| |:.|:
  Rat   198 APKFVLDLSRLDSRNDSLRAGLALLGALEGGGTPVPAAVLLGCSTARAHEVLEAAPPGPQWLLGT 262

  Fly   307 ------------------------HDL---IHDALQLFAQSWRNASFFYPDRMVVPR-ITCDFAA 343
                                    |.|   :||.::|.||:..:.:..:|:|.::|. :.||...
  Rat   263 PLPAEALPTTGLPPGVLALGETEQHSLEAVVHDMVELVAQALSSMALVHPERALLPAVVNCDDLK 327

  Fly   344 SGGRTWAMGRYLARLMKGTSGVNNTNF--RTSILQFDEDGQ-RITFNIEVY----DPLDGIGIAI 401
            :|| :.|.||.|||.:      .||:|  ||..:......| .::.:.:|:    |||   |...
  Rat   328 TGG-SEATGRTLARFL------GNTSFQGRTGAVWVTGSSQVHVSRHFKVWSLRRDPL---GAPA 382

  Fly   402 WDPRG--QITQLNVD-------------VKAQKKMIYRVATRIGPPYF----------------- 434
            |...|  |..||:..             .:|:.|:  ||.|.:..|:.
  Rat   383 WATVGSWQDGQLDFQPGAAALRVPSPSGTQARPKL--RVVTLVEHPFVFTRESDEDGQCPAGQLC 445

  Fly   435 ---SYNETARELNLTGNALYQ------------GYAVDLIDAIARHVGFEYVFVPVADQQYGKLD 484
               ..|::|| |:....||..            ||.:||::.:|..:.|::....|.|.:||.|
  Rat   446 LDPGTNDSAR-LDALFAALVNGSVPRTLRRCCYGYCIDLLERLAEDLAFDFELYIVGDGKYGAL- 508

  Fly   485 KETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKTLDAYLA 549
             ...:|.|::|:::...|||.:...:|..||...||||.||....:.|:. ::......:.|::.
  Rat   509 -RDGRWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMV-RTRDTASPIGAFMW 571

  Fly   550 PFGGEVWIWILISVFVMTFLKTIVARISKMDWENPH---PCNRDPEVLENQWRIHNTGWLTVASI 611
            |....:|:.:..::.:.....|:      .:|.:|:   |..|            |.|  ||.|.
  Rat   572 PLHWSMWVGVFAALHLTALFLTL------YEWRSPYGLTPRGR------------NRG--TVFSY 616

  Fly   612 MTA---------GCDI---LPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLK 664
            .:|         |..:   .|:.|..|.....|.||.:::.:||||||||.:...|....::.:.
  Rat   617 SSALNLCYAILFGRTVSSKTPKCPTGRFLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIH 681

  Fly   665 DLS---AQKKVKFGTIYGGSTYNLLADSNETVYRLAFNLMNNDDPSAYTKDNLEGV-----DRVR 721
            |..   ..:..:|||::..|.        |...:.:|..|:.............||     |..:
  Rat   682 DPKLHHPSQGFRFGTVWESSA--------EAYIKASFPEMHAHMRRHSAPTTPHGVAMLTSDPPK 738

  Fly   722 KNRGDYMFLMETTTLEYH--REQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGE 784
            .|    .|:|:.:.|:|.  .:.:|.|.:||:.|..:.|.|.:|..:...||||..|.:....|.
  Rat   739 LN----AFIMDKSLLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGF 799

  Fly   785 LYDLKQKWWKNPNASC----FEEPDPDATPDMTFEELRGIFYTLYAGILIAFLIGITEFLVY 842
            :..|..||:|  ...|    |...:   |..|......|:|..|..|:..|.|..:.|.:.|
  Rat   800 IDLLHDKWYK--MVPCGKRVFAVTE---TLQMGVYHFSGLFVLLCLGLGSALLTSLGEHVFY 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	83/391 (21%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	30/115 (26%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	100/427 (23%)
		Lig_chan	554..828	CDD:278489	69/302 (23%)
Grin3b	NP_579842.2	PBP1_iGluR_NMDA_NR3	21..405	CDD:107372	87/411 (21%)
		PBP2_iGluR_NMDA_Nr3	414..808	CDD:270438	100/431 (23%)
		Lig_chan	576..842	CDD:278489	69/302 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	882..910
		Involved in the trafficking and surface expression of NMDARs. /evidence=ECO:0000250	951..984
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349739
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840