Protein Alignment GluRIIC and gria2b

DIOPT Version :10

• Sequence 1: NP_608557.4
• Gene: GluRIIC / 33275
• FlyBaseID: FBgn0046113
• Length: 940
• Species: Drosophila melanogaster
• Sequence 2: XP_068069253.1
• Gene: gria2b / 170451
• ZFINID: ZDB-GENE-020125-4
• Length: 944
• Species: Danio rerio
• Alignment Length: 943
• Identity: 256/943 - (27%)
• Similarity: 423/943 - (44%)
• Gaps: 139/943 - (14%)

  Fly     6 LLLGCMWSAFFMCRSRGQQINIGAFF---YDDELELEK----EFMTVVNAINGPESEQTMRFYPL 63
            ||||       |.......:.||..|   .|.|....:    :|.|.           ..|..|.
Zfish    14 LLLG-------MTTGGSPSVQIGGLFPRGADQEYSAFRIGMVQFGTA-----------EFRLTPH 60

  Fly    64 IKRLKPEDGSVTMQEHACDLIDNGVAAIFGPSSKAASDIVALVCNSTGIPHIEFDISDEGIQAEK 128
            |..|:..: |..:....|.....||.||||...|.:.:.:...|   |..|:.|      |....
Zfish    61 IDNLEVAN-SFAVTNCFCSQFSRGVYAIFGFYDKKSVNTITSFC---GTLHVSF------ITPSF 115

  Fly   129 P---NHQMTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLL--------QLR 182
            |   |.|..:.:.|.   :......:::.:.|.||..:||:|  |....||.:|        |:.
Zfish   116 PLDGNQQFIIQMRPD---IKGPLLSLIEYYKWDKFAYLYDSD--RGLTTLQVVLDTAAEKKWQVT 175

  Fly   183 EVHNDVVRVRKFHKDDDFRVMWKSI--RGERRVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTN 245
            .:  :|..::...||:.:|.:::.:  :.||||:||||.:.:.:::......|...:..|..:.|
Zfish   176 AI--NVGNMKDERKDEAYRSLFQDLENKKERRVILDCEQDKVKDIMEQVITIGRHVKGYHYIIAN 238

  Fly   246 LETYTDHLEELAADNETFAVNITAARLLVNPDP--PPYSLPYGYVTQRDNIVYESSDPPRTLIHD 308
            |......|.::    :....|::..:::...||  ..:...:..:.:::   |..:|........
Zfish   239 LGFVDGDLSKI----QYGGANVSGFQIVDFDDPLVSKFDQRWEALEEKE---YPGADSKIRYTSA 296

  Fly   309 LIHDALQLFAQSWRNASFFYPDRMVVPR--ITCDFAASGGRTWAMGRYLARLMKGTSGVNNTNFR 371
            |.:||:|:..:::|   :.:..|:.:.|  ...|..|:....||.|..:.|.:|..    ..:..
Zfish   297 LTYDAVQVMTEAFR---YLHKQRIDISRRANNGDCLANPAVPWAQGVEIERALKQV----RVDGL 354

  Fly   372 TSILQFDEDGQRITFNIEVYD--PLDGIGIAIWD--PRGQITQLNV---DVKAQKKMIYRVATRI 429
            |..:|||:.|:|:.:.:.|.:  ....:.|..|:  .:..:|:.::   |....:.....|.|.:
Zfish   355 TGNIQFDQYGKRVNYTVNVMELKSNGAVKIGYWNEVDKMVVTKSDLFPNDTMGLENKTVIVTTIL 419

  Fly   430 GPPYFSYNETARELNLTGNALYQGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQWNGII 494
            ..||....:.| :| ...|..|:||.|||...||:|.||:|....|.|.:||..|.|||.|||::
Zfish   420 EAPYVMLKKNA-DL-FMDNERYEGYCVDLAAEIAKHCGFKYQLKIVGDGKYGARDAETKIWNGMV 482

  Fly   495 GEIINNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKTLDAYLAPFGGEVWIWI 559
            ||::...|.:.:..||||..|:..:||:.|||.||:||:..|....:..:.::|.|...|:|:.|
Zfish   483 GELVYGKADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCI 547

  Fly   560 L---ISVFVMTFLKTIVARISKMDWENPHPCNRDPEVLE--NQWRIHNTGWLTVASIMTAGCDIL 619
            :   |.|.|:.||   |:|.|..:|......:...:..|  |::.|.|:.|.::.:.|..||||.
Zfish   548 VFAYIGVSVVLFL---VSRFSPYEWHTEEYEDGQIQTNESTNEFGIFNSLWFSLGAFMRQGCDIS 609

  Fly   620 PRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLSAQKKVKFGTIYGGSTYN 684
            |||...|:....||.|.:||.:|||||||||||..:|...|.:.:||:.|.::.:||:..|||..
Zfish   610 PRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKE 674

  Fly   685 LLADSNETVYRLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFLMETTTLEY-HREQNCDLRS 748
            ....|...::...:..|...:||.:.|...|||.||||::|.|.:|:|:|..|| .:.:.||...
Zfish   675 FFRRSKIALFDKMWTYMKGAEPSVFVKTTAEGVMRVRKSKGKYAYLLESTMNEYIEQRKPCDTMK 739

  Fly   749 VGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNP--------NASCFEEPD 805
            ||.....|.|.||.|.|:..|:.:::|:|||:|:|.|..||.|||.:.        ::.......
Zfish   740 VGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKVSPREQ 804

  Fly   806 PDATP----------DMTFEELR------------------------------GIFYTLYAGILI 830
            .|.||          ..|.::|:                              |:||.|..|:.:
Zfish   805 SDGTPVNLAVLKLSEQGTLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGGLGL 869

  Fly   831 AFLIGITEFLVYVQQVALEERLTFKDAFKKEIR 863
            |.|:.:.||....:..|...::||.||.:.:.|
Zfish   870 AMLVALVEFCYKSRAEAKRMKVTFSDAMRSKAR 902

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	Periplasmic_Binding_Protein_type1	26..409	CDD:471960	85/410 (21%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	143/376 (38%)
		Lig_chan	554..827	CDD:459656	103/326 (32%)
gria2b	XP_068069253.1	PBP1_iGluR_AMPA_GluR2	27..397	CDD:380612	85/411 (21%)
		PBP2_iGluR_AMPA	410..790	CDD:270433	144/384 (38%)