Protein Alignment GluRIIC and gria2a

DIOPT Version :10

• Sequence 1: NP_608557.4
• Gene: GluRIIC / 33275
• FlyBaseID: FBgn0046113
• Length: 940
• Species: Drosophila melanogaster
• Sequence 2: XP_005170953.1
• Gene: gria2a / 170450
• ZFINID: ZDB-GENE-020125-3
• Length: 893
• Species: Danio rerio
• Alignment Length: 899
• Identity: 255/899 - (28%)
• Similarity: 422/899 - (46%)
• Gaps: 94/899 - (10%)

  Fly     6 LLLGCMWSAFFMCRSRGQQINIGAFF---YDDELELEK----EFMTVVNAINGPESEQTMRFYPL 63
            |||..:|.   :.......:.||..|   .|.|....:    :|.|.           ..|..|.
Zfish     6 LLLPALWG---LALGGSPSVQIGGLFPRGADQEYSAFRIGMVQFGTA-----------EFRLTPH 56

  Fly    64 IKRLKPEDGSVTMQEHACDLIDNGVAAIFGPSSKAASDIVALVCNSTGIPHIEFDISDEGIQAEK 128
            |..|:..: |..:....|.....||.||||...|.:.:.:...|.:..:..|......:|:
Zfish    57 IDNLEVAN-SFAITNCFCSQFSRGVYAIFGFYDKKSVNTITSFCETLHVSFITPSFPADGL---- 116

  Fly   129 PNHQMTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQLREVHNDVVRVRK 193
              :|..|.:.|.   :......:|:.:.|.||..:||:|  |..:.||.:|       |....||
Zfish   117 --NQFVLQMRPD---IKGPLISLVEYYKWEKFAYLYDSD--RGLSTLQAVL-------DTAAERK 167

  Fly   194 FH-------------KDDDFRVMWKSI--RGERRVVLDCEPNMLVELLNSSTEFGLTGQYNHIFL 243
            :.             ||:.:|.:::.:  :.||||:||||.:.:.:::......|...:..|..:
Zfish   168 WQVTAINVGNLKDEWKDEAYRSLFQDLENKNERRVILDCEQDKVKDIMEQVITIGRHVKGYHYII 232

  Fly   244 TNLETYTDHLEELAADNETFAVNITAARLLVNPDP--PPYSLPYGYVTQRDNIVYESSDPPRTLI 306
            .|.......|.::    :....|::..:::...||  ..:...:..:.:::   |..:|......
Zfish   233 ANFGFVDGDLSKI----QYGGANVSGFQIVDFDDPLVAKFDQRWEALEEKE---YPGADSRIRYT 290

  Fly   307 HDLIHDALQLFAQSWRNASFFYPDRMVVPR--ITCDFAASGGRTWAMGRYLARLMKGTSGVNNTN 369
            ..|.:||:|:..:::|   |.:..|:.:.|  ...|..|:....||.|..:.|.:|..    ..:
Zfish   291 SALTYDAVQVMTEAFR---FLHKQRIDISRRGNNGDCLANPAVPWAQGVEIERALKQV----RVD 348

  Fly   370 FRTSILQFDEDGQRITFNIEVYDPLDG--IGIAIWDPRGQ--ITQLNV---DVKAQKKMIYRVAT 427
            ..|..:|||:.|:|:.:.:.|.:..:.  :.|..|:...:  :|:.::   |....:.....|.|
Zfish   349 GLTGNIQFDQYGRRVNYTVNVMELKNSGPVKIGYWNEMDKMAVTKSDLFPNDTMGMENKTVIVTT 413

  Fly   428 RIGPPYFSYNETARELNLTGNALYQGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQWNG 492
            .:..||....:.| || .|.|..|:||.|||...||:|.||:|....|||.:||..|.|||.|||
Zfish   414 ILEAPYVMLKKNA-EL-FTDNERYEGYCVDLAAEIAKHCGFKYQLRIVADGKYGARDAETKIWNG 476

  Fly   493 IIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKTLDAYLAPFGGEVWI 557
            ::||::...|.:.:..||||..|:..:||:.|||.||:||:..|....:..:.::|.|...|:|:
Zfish   477 MVGELVYGKADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWM 541

  Fly   558 WIL---ISVFVMTFLKTIVARISKMDW--ENPHPCNRDPEVLENQWRIHNTGWLTVASIMTAGCD 617
            .|:   |.|.|:.||   |:|.|..:|  |........|....|::.|.|:.|.::.:.|..|||
Zfish   542 CIVFAYIGVSVVLFL---VSRFSPYEWHTEEFEDGQLGPSESTNEFGIFNSLWFSLGAFMQQGCD 603

  Fly   618 ILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLSAQKKVKFGTIYGGST 682
            |.|||...|:....||.|.:||.:|||||||||||..:|...|.:.:||:.|.::.:||:..|||
Zfish   604 ISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDAGST 668

  Fly   683 YNLLADSNETVYRLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFLMETTTLEY-HREQNCDL 746
            ......|...::...:..|.:.:||.:.|:.:|||.||||::|.|.:|:|:|..|| .:.:.||.
Zfish   669 KEFFRRSKIALFDKMWQYMKSAEPSVFVKNTVEGVLRVRKSKGKYAYLLESTMNEYIEQRKPCDT 733

  Fly   747 RSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNPNASCFE--EPDPDAT 809
            ..||.....|.|.||.|.|:..|:.:::|:|||:|:|.|..||.|||.: ...|..  ....:.|
Zfish   734 MKVGGNLDSKGYGIATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWYD-KGECGSGGGESKEKT 797

  Fly   810 PDMTFEELRGIFYTLYAGILIAFLIGITEFLVYVQQVALEERLTFKDAFKKEIR 863
            ..::...:.|:||.|..|:.:|.|:.:.||....:..|...::||.||.:.:.|
Zfish   798 SALSLSNVAGVFYILVGGLGLAMLVALVEFCYKSRAEAKRMKMTFTDAMRSKAR 851

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	Periplasmic_Binding_Protein_type1	26..409	CDD:471960	84/412 (20%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	147/376 (39%)
		Lig_chan	554..827	CDD:459656	101/280 (36%)
gria2a	XP_005170953.1	Periplasmic_Binding_Protein_type1	23..393	CDD:471960	84/413 (20%)
		PBP2_iGluR_AMPA	406..783	CDD:270433	148/382 (39%)