Protein Alignment GluRIIC and Grin2c

DIOPT Version :10

• Sequence 1: NP_608557.4
• Gene: GluRIIC / 33275
• FlyBaseID: FBgn0046113
• Length: 940
• Species: Drosophila melanogaster
• Sequence 2: XP_017169765.1
• Gene: Grin2c / 14813
• MGIID: 95822
• Length: 1307
• Species: Mus musculus
• Alignment Length: 1005
• Identity: 219/1005 - (21%)
• Similarity: 376/1005 - (37%)
• Gaps: 241/1005 - (23%)

  Fly    43 MTVVNAINGPESEQT------MRFYPLIKRLKP--------EDGSVTMQEHACDLIDNGVAAIFG 93
            :.||...:||...|.      ..|..|...::|        ...|:..|  .|.|:  |.|.:.|
Mouse    94 VAVVFGSSGPLQAQARTRLTPQNFLDLPLEIQPLTIGVNNTNPSSILTQ--ICGLL--GAARVHG 154

  Fly    94 ------PSSKAASDIVALVCNSTGIPHIEFDISDEGIQAEK-PNH---QMTLNLYPAQAILSKAY 148
                  ..::|.:.::..|.:.|.:|.:........:...| |..   |:.::|.....:|.|
Mouse   155 IVFEDNVDTEAVAQLLDFVSSQTHVPILSISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVLFK-- 217

  Fly   149 ADIVQNFGWRKFTIVYD---------------ADDARAAARLQDLLQLR-EVHNDVVRVRKFHKD 197
              :::.:.|..|.::..               ||.:..:.||.|:|.|. .......|.::..:.
Mouse   218 --VLEEYDWSAFAVITSLHPGHALFLEGVRAVADASYLSWRLLDVLTLELGPGGPRARTQRLLRQ 280

  Fly   198 DDFRVMWKSIRGERRVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLT-NLETYTDHLEELAADNE 261
            .|..|:          |..|.......|...:.:.||.|. .|::|. ||
Mouse   281 VDAPVL----------VAYCSREEAEVLFAEAAQAGLVGP-GHVWLVPNL--------------- 319

  Fly   262 TFAVNITAARLLVNPDPPPYSLPYGYVTQRDNIVYESSDPPRTLIHDLIHDA---LQLFAQSWRN 323
                      .|.:.|.||.:.|.|.:    ::|.||.   |..:...:.|.   |.|.|.|:|.
Mouse   320 ----------ALGSTDAPPAAFPVGLI----SVVTESW---RLSLRQKVRDGVAILALGAHSYRR 367

  Fly   324 ----------------------ASFFYPDRMVVPRITCDFAASGG----------------RTWA 350
                                  ...||...:.|.....||:.|.|                |.|.
Mouse   368 QYGTLPAPAGDCRSHPGPVSPAREAFYRHLLNVTWEGRDFSFSPGGYLVQPTMVVIALNRHRLWE 432

  Fly   351 M-GRYLARLMKGTSGVNNTNF-----RTSILQFDEDGQRITFN---------IEVYDPLDGIGIA 400
            | ||:       ..||....:     .::.||...|.:.:|..         :|..||  |.|..
Mouse   433 MVGRW-------DHGVLYMKYPVWPRYSTSLQPVVDSRHLTVATLEERPFVIVESPDP--GTGGC 488

  Fly   401 IWDPRGQITQLNVDVKAQKKMIYRVATRIGPPYFSYNETARELNLT--GNALYQGYAVDLIDAIA 463
            :  |.      .|..:.|.                 |.|....::|  .....:|:.:|::..:|
Mouse   489 V--PN------TVPCRRQS-----------------NHTFSSGDITPYTKLCCKGFCIDILKKLA 528

  Fly   464 RHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQL 528
            :.|.|.|....|.:.::||  :....|||:|||:....|.|.|..|||.:.|...:||:|||::.
Mouse   529 KVVKFSYDLYLVTNGKHGK--RVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIIDFSVPFVET 591

  Fly   529 GVSILAYKSPHVEKTLDAYLAPFGGEVWIWILISVFVMTFLKTIVARISKMDWENPHPCNRDPEV 593
            |:|::..:| :...:..|:|.|:...||    :.:|||..  |:|| |:...:|...|.:.:..:
Mouse   592 GISVMVARS-NGTVSPSAFLEPYSPAVW----VMMFVMCL--TVVA-ITVFMFEYFSPVSYNQNL 648

  Fly   594 LENQ------WRIHNTGWLTVASIMTAGCDI-LPRSPQVRMFEATWWIFAIIIANSYTANLAAFL 651
            .:.:      :.|..:.||..|.:......| .||....::....|..||:|...|||||||||:
Mouse   649 TKGKKSGGPSFTIGKSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFM 713

  Fly   652 TSSKMEGSIANLKDLSAQK------KVKFGTIYGGST-YNLLADSNET-VYRLAFNLMNNDDPSA 708
            ...:...:::.|.|...|:      ..:|||:..||| .|:.::..:. .:.:.||..:.:|...
Mouse   714 IQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQRSVEDALT 778

  Fly   709 YTKDNLEGVDRVRKNRGDYMFLMETTTLEY--HREQNCDLRSV--GEKFGEKHYAIAVPFGAEYR 769
            ..|.....|.|...     .|:.:...|.|  .:::.|.|.::  |:.|....|.||:...:.::
Mouse   779 SLKMGARHVSRKLD-----AFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWK 838

  Fly   770 SNLSVAILKLSERGELYDLKQKWWKNPNASCFEEPDPDATPDMTFEELRGIFYTLYAGILIAFLI 834
            ..:.:|:|:....||...|:..|.   :..|..|.:...:..:..:.:.|:||.|...:.:|.|:
Mouse   839 RAIDLALLQFLGDGETQKLETVWL---SGICHNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLV 900

  Fly   835 GITEFLVYVQ---QVALEERLTFKDAFKKEIRFVLCVWNNRKPIVAGTPISSVRTTPRRSLDKSL 896
            ...|.|||.:   .|....:|.|..||.:.|  ..|             .:.|::.|..:...|.
Mouse   901 FAWEHLVYWKLRHSVPSSSQLDFLLAFSRGI--YSC-------------FNGVQSLPSPARPPSP 950

  Fly   897 DRTPKSSRRVVIG--RSSEEMREMAQGSGS 924
            |.|..|::..|:.  :::.:|...|..|||
Mouse   951 DLTAGSAQANVLKMLQAARDMVSTADVSGS 980

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	Periplasmic_Binding_Protein_type1	26..409	CDD:471960	87/462 (19%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	99/391 (25%)
		Lig_chan	554..827	CDD:459656	69/291 (24%)
Grin2c	XP_017169765.1	PBP1_iGluR_NMDA_NR2	90..446	CDD:380601	77/409 (19%)
		PBP2_iGluR_NMDA_Nr2	462..868	CDD:270436	109/450 (24%)
		NMDAR2_C	905..>980	CDD:463148	20/89 (22%)