DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GluRIIC and Grin2c

DIOPT Version :9

Sequence 1:NP_608557.4 Gene:GluRIIC / 33275 FlyBaseID:FBgn0046113 Length:940 Species:Drosophila melanogaster
Sequence 2:XP_017169765.1 Gene:Grin2c / 14813 MGIID:95822 Length:1307 Species:Mus musculus


Alignment Length:1005 Identity:219/1005 - (21%)
Similarity:376/1005 - (37%) Gaps:241/1005 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 MTVVNAINGPESEQT------MRFYPLIKRLKP--------EDGSVTMQEHACDLIDNGVAAIFG 93
            :.||...:||...|.      ..|..|...::|        ...|:..|  .|.|:  |.|.:.|
Mouse    94 VAVVFGSSGPLQAQARTRLTPQNFLDLPLEIQPLTIGVNNTNPSSILTQ--ICGLL--GAARVHG 154

  Fly    94 ------PSSKAASDIVALVCNSTGIPHIEFDISDEGIQAEK-PNH---QMTLNLYPAQAILSKAY 148
                  ..::|.:.::..|.:.|.:|.:........:...| |..   |:.::|.....:|.|  
Mouse   155 IVFEDNVDTEAVAQLLDFVSSQTHVPILSISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVLFK-- 217

  Fly   149 ADIVQNFGWRKFTIVYD---------------ADDARAAARLQDLLQLR-EVHNDVVRVRKFHKD 197
              :::.:.|..|.::..               ||.:..:.||.|:|.|. .......|.::..:.
Mouse   218 --VLEEYDWSAFAVITSLHPGHALFLEGVRAVADASYLSWRLLDVLTLELGPGGPRARTQRLLRQ 280

  Fly   198 DDFRVMWKSIRGERRVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLT-NLETYTDHLEELAADNE 261
            .|..|:          |..|.......|...:.:.||.|. .|::|. ||               
Mouse   281 VDAPVL----------VAYCSREEAEVLFAEAAQAGLVGP-GHVWLVPNL--------------- 319

  Fly   262 TFAVNITAARLLVNPDPPPYSLPYGYVTQRDNIVYESSDPPRTLIHDLIHDA---LQLFAQSWRN 323
                      .|.:.|.||.:.|.|.:    ::|.||.   |..:...:.|.   |.|.|.|:|.
Mouse   320 ----------ALGSTDAPPAAFPVGLI----SVVTESW---RLSLRQKVRDGVAILALGAHSYRR 367

  Fly   324 ----------------------ASFFYPDRMVVPRITCDFAASGG----------------RTWA 350
                                  ...||...:.|.....||:.|.|                |.|.
Mouse   368 QYGTLPAPAGDCRSHPGPVSPAREAFYRHLLNVTWEGRDFSFSPGGYLVQPTMVVIALNRHRLWE 432

  Fly   351 M-GRYLARLMKGTSGVNNTNF-----RTSILQFDEDGQRITFN---------IEVYDPLDGIGIA 400
            | ||:       ..||....:     .::.||...|.:.:|..         :|..||  |.|..
Mouse   433 MVGRW-------DHGVLYMKYPVWPRYSTSLQPVVDSRHLTVATLEERPFVIVESPDP--GTGGC 488

  Fly   401 IWDPRGQITQLNVDVKAQKKMIYRVATRIGPPYFSYNETARELNLT--GNALYQGYAVDLIDAIA 463
            :  |.      .|..:.|.                 |.|....::|  .....:|:.:|::..:|
Mouse   489 V--PN------TVPCRRQS-----------------NHTFSSGDITPYTKLCCKGFCIDILKKLA 528

  Fly   464 RHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQL 528
            :.|.|.|....|.:.::||  :....|||:|||:....|.|.|..|||.:.|...:||:|||::.
Mouse   529 KVVKFSYDLYLVTNGKHGK--RVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIIDFSVPFVET 591

  Fly   529 GVSILAYKSPHVEKTLDAYLAPFGGEVWIWILISVFVMTFLKTIVARISKMDWENPHPCNRDPEV 593
            |:|::..:| :...:..|:|.|:...||    :.:|||..  |:|| |:...:|...|.:.:..:
Mouse   592 GISVMVARS-NGTVSPSAFLEPYSPAVW----VMMFVMCL--TVVA-ITVFMFEYFSPVSYNQNL 648

  Fly   594 LENQ------WRIHNTGWLTVASIMTAGCDI-LPRSPQVRMFEATWWIFAIIIANSYTANLAAFL 651
            .:.:      :.|..:.||..|.:......| .||....::....|..||:|...|||||||||:
Mouse   649 TKGKKSGGPSFTIGKSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFM 713

  Fly   652 TSSKMEGSIANLKDLSAQK------KVKFGTIYGGST-YNLLADSNET-VYRLAFNLMNNDDPSA 708
            ...:...:::.|.|...|:      ..:|||:..||| .|:.::..:. .:.:.||..:.:|...
Mouse   714 IQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQRSVEDALT 778

  Fly   709 YTKDNLEGVDRVRKNRGDYMFLMETTTLEY--HREQNCDLRSV--GEKFGEKHYAIAVPFGAEYR 769
            ..|.....|.|...     .|:.:...|.|  .:::.|.|.::  |:.|....|.||:...:.::
Mouse   779 SLKMGARHVSRKLD-----AFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWK 838

  Fly   770 SNLSVAILKLSERGELYDLKQKWWKNPNASCFEEPDPDATPDMTFEELRGIFYTLYAGILIAFLI 834
            ..:.:|:|:....||...|:..|.   :..|..|.:...:..:..:.:.|:||.|...:.:|.|:
Mouse   839 RAIDLALLQFLGDGETQKLETVWL---SGICHNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLV 900

  Fly   835 GITEFLVYVQ---QVALEERLTFKDAFKKEIRFVLCVWNNRKPIVAGTPISSVRTTPRRSLDKSL 896
            ...|.|||.:   .|....:|.|..||.:.|  ..|             .:.|::.|..:...|.
Mouse   901 FAWEHLVYWKLRHSVPSSSQLDFLLAFSRGI--YSC-------------FNGVQSLPSPARPPSP 950

  Fly   897 DRTPKSSRRVVIG--RSSEEMREMAQGSGS 924
            |.|..|::..|:.  :::.:|...|..|||
Mouse   951 DLTAGSAQANVLKMLQAARDMVSTADVSGS 980

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GluRIICNP_608557.4 PBP1_iGluR_Kainate 26..404 CDD:107377 86/457 (19%)
Periplasmic_Binding_Protein_Type_1 <279..363 CDD:299141 26/125 (21%)
PBP2_iGluR_Kainate 423..794 CDD:270432 99/391 (25%)
Lig_chan 554..828 CDD:278489 69/292 (24%)
Grin2cXP_017169765.1 PBP1_iGluR_NMDA_NR2 90..446 CDD:380601 77/409 (19%)
PBP2_iGluR_NMDA_Nr2 462..868 CDD:270436 109/450 (24%)
NMDAR2_C 905..>980 CDD:371139 20/89 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167846274
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.840

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