DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIC and Grin2b

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_001350679.1	Gene:	Grin2b / 14812	MGIID:	95821	Length:	1482	Species:	Mus musculus

Alignment Length:	952	Identity:	206/952 - (21%)
Similarity:	348/952 - (36%)	Gaps:	253/952 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 CDLIDN----GVAAIFGPSSKAASDIVALVCNSTGIPHIEFDISDEGIQAEKPNHQMTLNLYPAQ 141
            |||:.:    ||........:|.:.|:..:...|..|.:........|.|:|....|.....|:.
Mouse    86 CDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGGSSMIMADKDESSMFFQFGPSI 150

  Fly   142 AILSKAYADIVQNFGWRKFTIV------YD---------ADDARAAARLQDLLQLREVHNDVVRV 191
            ...:....:|::.:.|..|:||      |.         .:::.....|:::|.|....:|
Mouse   151 EQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIRSTIENSFVGWELEEVLLLDMSLDD---- 211

  Fly   192 RKFHKDDDFRVMWKSIRGERRVVLDC---EPNMLVELLNSSTEFGLTGQYNHIFLTNLETYTDHL 253
                .|...:...|.::.. .::|.|   |...:.|:.||   .|||| |.:.::..
Mouse   212 ----GDSKIQNQLKKLQSP-IILLYCTKEEATYIFEVANS---VGLTG-YGYTWIVP-------- 259

  Fly   254 EELAADNETFAVNITAARLLVNPDPPPYSLPYGYVTQRDNIVYESSDPPRTLIHDLIHDALQLFA 318
            ..:|.|.:|.........:.|:.|...|.||   ...||.|...:     |...|::.:
Mouse   260 SLVAGDTDTVPSEFPTGLISVSYDEWDYGLP---ARVRDGIAIIT-----TAASDMLSE------ 310

  Fly   319 QSWRNASFFYPDRMVVPRITCDFAASGGRTW---AMGRYLARLMKGTSGVNNTNFRTSILQFDED 380
                  ..|.|:    |:.:| :.....|.:   .:.|||.          |..|....|.|.||
Mouse   311 ------HSFIPE----PKSSC-YNTHEKRIYQSNMLNRYLI----------NVTFEGRNLSFSED 354

  Fly   381 GQR-------ITFN--------------------------------------------------I 388
            |.:       |..|                                                  :
Mouse   355 GYQMHPKLVIILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIV 419

  Fly   389 EVYDPLDGIGIAIWDPRGQITQLNVDVKAQKKMIYRVATRIGPPYFSYNETARELNLTGNALYQG 453
            |..|||.|            |.:...|..||::|....|...|.|.             ....:|
Mouse   420 ESVDPLSG------------TCMRNTVPCQKRIISENKTDEEPGYI-------------KKCCKG 459

  Fly   454 YAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTA 518
            :.:|::..|::.|.|.|....|.:.::||  |....|||:|||::...|:|.:..|||.:.|...
Mouse   460 FCIDILKKISKSVKFTYDLYLVTNGKHGK--KINGTWNGMIGEVVMKRAYMAVGSLTINEERSEV 522

  Fly   519 VDFTVPFMQLGVSILAYKSPHVEKTLDAYLAPFGGEVWIWILISVFVMTFLKTIVARISKMDWEN 583
            |||:|||::.|:|::..:| :...:..|:|.||..:||    :.:|||..:.:.|| :...::.:
Mouse   523 VDFSVPFIETGISVMVSRS-NGTVSPSAFLEPFSADVW----VMMFVMLLIVSAVA-VFVFEYFS 581

  Fly   584 PHPCNR----DPEVLENQWRIHNTGWLTVASIMTAGCDIL-PRSPQVRMFEATWWIFAIIIANSY 643
            |...||    ..|.....:.|....||....:......:. |:....::..:.|..||:|...||
Mouse   582 PVGYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASY 646

  Fly   644 TANLAAFLTSSKMEGSIANLKDLSAQK------KVKFGTIYGGSTYNLLADSNETVYRLAFNLMN 702
            |||||||:...:....::.|.|...|:      ..:|||:..|||..              |:.|
Mouse   647 TANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTER--------------NIRN 697

  Fly   703 N-DDPSAYT-KDNLEGVD----RVRKNRGDYMFLMETTTLEY--HREQNCDLRSV--GEKFGEKH 757
            | .:..||. |.|..|||    .::..:.| .|:.:...|.|  .|::.|.|.::  |:.|....
Mouse   698 NYAEMHAYMGKFNQRGVDDALLSLKTGKLD-AFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTG 761

  Fly   758 YAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNPNASCFEEPDPDATPDMTFEELRGIFY 822
            |.||:...:.::..:.:|||:|...||:.:|:..|.   ...|..|.:...:..:..:.:.|:||
Mouse   762 YGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWL---TGICHNEKNEVMSSQLDIDNMAGVFY 823

  Fly   823 TLYAGILIAFLIGITEFLVY----------------------------VQQVALEER-------- 851
            .|.|.:.::.:..|.|.|.|                            :..||:|||
Mouse   824 MLGAAMALSLITFICEHLFYWQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNSPT 888

  Fly   852 LTFKDAFKKEIRFVLCVWNNRKPIVAGTPISSVRTTPRRSLD 893
            .|..:.....:|.:....|...       :|.|..:|:.:||
Mouse   889 ATMNNTHSNILRLLRTAKNMAN-------LSGVNGSPQSALD 923

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	72/404 (18%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	16/86 (19%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	105/391 (27%)
		Lig_chan	554..828	CDD:278489	74/294 (25%)
Grin2b	NP_001350679.1	PBP1_iGluR_NMDA_NR2	33..388	CDD:380601	67/357 (19%)
		PBP2_iGluR_NMDA_Nr2	403..803	CDD:270436	116/450 (26%)
		NMDAR2_C	840..1482	CDD:402274	15/91 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846234
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840