DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIC and Grik5

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	XP_030098003.1	Gene:	Grik5 / 14809	MGIID:	95818	Length:	1003	Species:	Mus musculus

Alignment Length:	921	Identity:	260/921 - (28%)
Similarity:	429/921 - (46%)	Gaps:	128/921 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 DGSVTMQEHACDLIDNGVAAIFGPSSKAAS-DIVALVCNSTGIPHIEFDISDEGIQAEKPNHQ-- 132
            |......:..|.::..||.::.||||..|| ..|:.:|....||||:  :..|    |.|..|
Mouse    73 DSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIK--VGPE----ETPRLQYL 131

  Fly   133 --MTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQLREVHNDVVRVRKFH 195
              .:::|||:...:|.|.:.|:::|.:...:::  ...|....||::|::...:..:.:.||...
Mouse   132 RFASVSLYPSNEDVSLAVSRILKSFNYPSASLI--CAKAECLLRLEELVRGFLISKETLSVRMLD 194

  Fly   196 KDDDFRVMWKSIRGER--RVVLDCE---PNMLVEL-LNSS-------------------TEFGLT 235
            ...|...:.|.||.::  .:::|..   .::::.| ||.|                   :|.|:|
Mouse   195 DSRDPTPLLKEIRDDKVSTIIIDANASISHLVLRLSLNLSSPLGFPRSLPLGLSCVLQASELGMT 259

  Fly   236 GQYNHIFLTNLETYTDHLEELAADNETFAVNITAARLLVNPDPPPY-----SLPYGYVTQRDNIV 295
            ..:....||.::....||:.:..|:.    ||....:. |...|.|     ||...:   |:| .
Mouse   260 SAFYKYILTTMDFPILHLDGIVEDSS----NILGFSMF-NTSHPFYPEFVRSLNMSW---REN-C 315

  Fly   296 YESSDPPRTLIHDLIHDALQLFAQSWR--NASFFYPDRMVVPRITCDFAASGGRTWAMGRYLARL 358
            ..|:.|...|...|:.||:.:...:.|  |.|    ..:.|..:.|    :....|..|..|...
Mouse   316 EASTYPGPALSAALMFDAVHVVVSAVRELNRS----QEIGVKPLAC----TSANIWPHGTSLMNY 372

  Fly   359 MKGT--SGVNNTNFRTSILQFDEDGQRITFNIEVYDPLDGIG---IAIWDPRGQI----TQLNVD 414
            ::..  .|:      |..::|:..|||..:.:.:.:. ...|   |.:|.....:    |.|:::
Mouse   373 LRMVEYDGL------TGRVEFNSKGQRTNYTLRILEK-SRQGHREIGVWYSNRTLAMNATTLDIN 430

  Fly   415 VK---AQKKMIYRVATRIGPPYFSYNETARELN---LTGNALYQGYAVDLIDAIARHVGFEYVFV 473
            :.   |.|.::  |.|.:..||     ..|..|   |:||..::|:.||::..:|..:.|.|...
Mouse   431 LSQTLANKTLV--VTTILENPY-----VMRRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLR 488

  Fly   474 PVADQQYGKLDKETKQWNGIIGEIINND-AHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKS 537
            .|.|..|| ..:....|.|::||:||.. |.:.:...|||..|:..:||:.|||.||:||| |:
Mouse   489 LVEDGLYG-APEPNGSWTGMVGELINRQKADLAVAAFTITAEREKVIDFSKPFMTLGISIL-YR- 550

  Fly   538 PHVEKT--LDAYLAPFGGEVWIWILISVFVMTFLKTIVARISKMDWENPHPCNR-DPEVLENQWR 599
            .|:.:.  ..::|.||...||:::|::...::.:..:.||:|..:|.|||||.| .|.:||||:.
Mouse   551 VHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYT 615

  Fly   600 IHNTGWLTVASIMTAGCDILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLK 664
            :.|:.|..|...|..|.:|:||:...|.....||.|.:||.:|||||||||||..:||..:.:..
Mouse   616 LGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESAD 680

  Fly   665 DLSAQKKVKFGTIYGGSTYNLLADSNETVYRLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMF 729
            ||:.|..:::|||:.|||.....:|....|:..:|.|.:..||.:.|...||:.||..:|  |.|
Mouse   681 DLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSR--YAF 743

  Fly   730 LMETTTLEYHREQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWK 794
            |:|:|..||||..||:|..:|.....|.|.|.:|.|:.:|..:::|||:|.|...|..||:|||:
Mouse   744 LLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWE 808

  Fly   795 NPNASCFEEPDPDATPDMTFEELRGIFYTLYAGILIAFLIGITEFLVYVQQVALEERLTFKDAFK 859
              ...|.:|.|..| ..:..|.:.|||..|..|::||..:.:.||:...::.|..|.::......
Mouse   809 --GGRCPKEEDHRA-KGLGMENIGGIFVVLICGLIIAVFVAVMEFIWSTRRSAESEEVSVCQEML 870

  Fly   860 KEIRFVLCVWNNRKPIVAGTPISSVRTTPRRSLDKSLDRTPKSSRRVVIGRSSEEMREMAQGSG- 923
            :|:|..:                |.|.|.|    ....|.|....|.::  |...:|||...:|
Mouse   871 QELRHAV----------------SCRKTSR----SRRRRRPGGPSRALL--SLRAVREMRLSNGK 913

  Fly   924 --SSSGSNNAG 932
              |:....:||
Mouse   914 LYSAGAGGDAG 924

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	82/374 (22%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	20/92 (22%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	140/377 (37%)
		Lig_chan	554..828	CDD:278489	105/274 (38%)
Grik5	XP_030098003.1	PBP1_iGluR_Kainate_KA1_2	23..424	CDD:380616	82/382 (21%)
Grik5	XP_030098003.1	Periplasmic_Binding_Protein_Type_2	437..808	CDD:419667	141/382 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846286
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.860