DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIC and Grik2

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	XP_011241422.1	Gene:	Grik2 / 14806	MGIID:	95815	Length:	943	Species:	Mus musculus

Alignment Length:	981	Identity:	277/981 - (28%)
Similarity:	457/981 - (46%)	Gaps:	184/981 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLLGCMWSAFFMCRSRG--QQINIGAFF-YDDELEL---EKEFMTVVNAINGPES---------- 54
            :||..:|..:    |:|  ..:..|..| |.:...:   |..|...||.||...:
Mouse    19 VLLCLLWIGY----SQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYD 79

  Fly    55 EQTMRFYPLIKRLKPEDGSVTMQEHACDLIDNGVAAIFGPSSKAASDIVALVCNSTGIPHIE--- 116
            .|.:..|          .|....:.|||.:..|||||||||..::::.|..:||:.|:|||:
Mouse    80 TQKINLY----------DSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRW 134

  Fly   117 -FDISDEGIQAEKPNHQMTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQ 180
             ..:||.       .....::|||..:.||:|..|:||.|.|:..|:||  ||:....|||:|::
Mouse   135 KHQVSDN-------KDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVY--DDSTGLIRLQELIK 190

  Fly   181 LREVHNDVVRVRKFHKD-DDFRVMWKSI-RG-ERRVVLDCEPNMLVELLNSSTEFGLTGQYNHIF 242
            ....:|..:::|:...| .|.:.:.|.: || |..|:.||...|...:|..:...|:..:|.|..
Mouse   191 APSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYI 255

  Fly   243 LTNLETYTDHLEELAADNETF---AVNITAARLLVN-------------------PDPPPYSLPY 285
            .|.|:.:       |.|.|.:   .||:|..|:|..                   |..|...|..
Mouse   256 FTTLDLF-------ALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLD 313

  Fly   286 GYVTQRDNIVYESSDPPRTLIHDLIHDALQLFAQSWRNASFFYPDRMVVPRITCDFAASGGRTWA 350
            |::|....::|::       :| ::..|:|.|.|            |.|..:.|    :..:.|.
Mouse   314 GFMTTDAALMYDA-------VH-VVSVAVQQFPQ------------MTVSSLQC----NRHKPWR 354

  Fly   351 MGRYLARLMK-----GTSG---VNNTNFRTSILQFDEDGQRITFNIEVY----DPLDGIGIAIWD 403
            .|.....|:|     |.:|   .|.||           |.|..|:::|.    :.|:.||  .||
Mouse   355 FGTRFMSLIKEAHWEGLTGRITFNKTN-----------GLRTDFDLDVISLKEEGLEKIG--TWD 406

  Fly   404 PRGQITQLN---------VDVKAQKKMIYRVATRIGPPYFSYNETARELNLTGNALYQGYAVDLI 459
            |...:....         .|..:.:.:|  |.|.:..||..:.::.:.  |.||..::||.:||:
Mouse   407 PSSGLNMTESQKGKPANITDSLSNRSLI--VTTILEEPYVLFKKSDKP--LYGNDRFEGYCIDLL 467

  Fly   460 DAIARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVP 524
            ..::..:||.|....|.|.:||..|....||||::.|:|::.|.:.:..|.||..|:..:||:.|
Mouse   468 RELSTILGFTYEIRLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKP 532

  Fly   525 FMQLGVSILAYKSPH-VEKTLDAYLAPFGGEVWIWILISVFVMTFLKTIVARISKM--------- 579
            ||.||:||| |:.|: ....:.::|.|...::|::||::...::.:..::||.||.
Mouse   533 FMTLGISIL-YRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARQSKFSWFKYPNCS 596

  Fly   580 --------------------------DWENPHPCNRDPEVLENQWRIHNTGWLTVASIMTAGCDI 618
                                      :|.||||||.|.:|:||.:.:.|:.|..|.::|..|.::
Mouse   597 HYHHSQRCLCTQHLESYMELCLFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSEL 661

  Fly   619 LPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLSAQKKVKFGTIYGGSTY 683
            :|::...|:....||.|.:||.:|||||||||||..:||..|.:..||:.|.|:::|.:..|:|.
Mouse   662 MPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATM 726

  Fly   684 NLLADSNETVYRLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFLMETTTLEYHREQNCDLRS 748
            .....|..:.|...:..|::...|...|.|.||:.||..:  ||.||||:||:|:..::||:|..
Mouse   727 TFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTS--DYAFLMESTTIEFVTQRNCNLTQ 789

  Fly   749 VGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNPNASCFEEPDPDATPDMT 813
            :|.....|.|.:..|.|:.||..:::|||:|.|.|:|:.:|:|||:  ...|.||...:|:. :.
Mouse   790 IGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWR--GNGCPEEESKEASA-LG 851

  Fly   814 FEELRGIFYTLYAGILIAFLIGITEFLVYVQQVALEERLTFKDAFKKEIRFVLCVWNNRK----- 873
            .:.:.|||..|.||::::..:.:.|||...::.|..|:.:|..|..:|:|..|......|
Mouse   852 VQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQA 916

  Fly   874 PIVAGT 879
            |::..|
Mouse   917 PVIVKT 922

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	110/432 (25%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	18/88 (20%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	134/406 (33%)
		Lig_chan	554..828	CDD:278489	100/308 (32%)
Grik2	XP_011241422.1	PBP1_iGluR_Kainate	37..414	CDD:380605	112/439 (26%)
Grik2	XP_011241422.1	Periplasmic_Binding_Protein_Type_2	430..835	CDD:389745	135/411 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846278
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.860