Protein Alignment GluRIIC and Grid1

DIOPT Version :10

• Sequence 1: NP_608557.4
• Gene: GluRIIC / 33275
• FlyBaseID: FBgn0046113
• Length: 940
• Species: Drosophila melanogaster
• Sequence 2: NP_032192.2
• Gene: Grid1 / 14803
• MGIID: 95812
• Length: 1009
• Species: Mus musculus
• Alignment Length: 911
• Identity: 221/911 - (24%)
• Similarity: 389/911 - (42%)
• Gaps: 147/911 - (16%)

  Fly    11 MWSAFFMCRS---RGQQ-INIGAFFYDDELELEKEFMTVVNAIN-GPESEQTMRFYPLIKRLKPE 70
            :|...::|:.   |... |:|||.|.::..:.::.|...|:.:: ..:..|:.:....||.::..
Mouse     6 LWLLPWICQCVTVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEAN 70

  Fly    71 DGSVTMQEHACDLIDNGVAAIFGPSSKAASDIVALVCNSTGIPHIEFDISDEGIQAEKPNHQMTL 135
            :....:|| ||||:..|:.|:...:..|:::.:..:.::..|||:....:..|    .|.....|
Mouse    71 NPFQAVQE-ACDLMTQGILALVTSTGCASANALQSLTDAMHIPHLFVQRNPGG----SPRTACHL 130

  Fly   136 NLYP---AQAILSK-------AYADIVQNFGWRKFTIVYDAD-DARA-------AARLQDLLQLR 182
            |..|   |..:.|:       ....:|....|:||.:.||:: |.|.       |:||...:.|:
Mouse   131 NPSPDGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQ 195

  Fly   183 EVHNDVVRVRKFHKDDDFRVMWKSIRGE---------RRVVLDCEPNMLVELLNSSTEFGLTGQY 238
            :|..::..|        |..::.:::.|         ||.:|...|......:|.:.|..|..:.
Mouse   196 KVDKNISHV--------FTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEAVETNLASKD 252

  Fly   239 NHIFLTNLETYTDHLEEL-----------------AADNE-TFAVNITAARLLVNPDPPPYSLPY 285
            :|....|.|.....:.:|                 |.||: ....|...:.||.:|..
Mouse   253 SHWVFVNEEISDPEILDLVHSALGRMTVVRQIFPSAKDNQKCMRNNHRISSLLCDPQE------- 310

  Fly   286 GY--VTQRDNI-VYESSDPPRTLIHDLIHDALQLFAQSWRNASFFYPDRMVVPRITCDFAASGGR 347
            ||  :.|..|: :|:|........|..:.|      :.|.:          :..:.|  .....:
Mouse   311 GYLQMLQISNLYLYDSVLMLANAFHRKLED------RKWHS----------MASLNC--IRKSTK 357

  Fly   348 TWAMGR-YLARLMKG-TSGVNNTNFRTSILQFDEDGQRITFNIEV----YDPLDGIG---IAIWD 403
            .|..|| .|..:.|| .:|:      |.:::|.||........|:    |....|..   :|.||
Mouse   358 PWNGGRSMLDTIKKGHITGL------TGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWD 416

  Fly   404 P----RGQITQLNVDVKAQKKMIYRVATRIGPPYFSYNETARELNLTGN-ALYQGYAVDLIDAIA 463
            .    .|.:.:..:..:.| .:..:|.|.:..|:....|     |:.|. ..|:|:::|::||:|
Mouse   417 SEKGLNGSLQERPMGSRLQ-GLTLKVVTVLEEPFVMVAE-----NILGQPKRYKGFSIDVLDALA 475

  Fly   464 RHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQL 528
            :.:||:|......|.:||.....| .|||:|||:|:..|.:.|..:|||..|::.|||:..:|..
Mouse   476 KALGFKYEIYQAPDGRYGHQLHNT-SWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDY 539

  Fly   529 GVSILAYKSPHVEKTLDAYLAPFGGEVWIWILISVFVMTFLKTIVARISKMDWEN---PHPCNRD 590
            .|.|| .|.|..:.::.:..|||...||..|..::.|:..|..::.||..:..::   |.|
Mouse   540 SVGIL-IKKPEEKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVRSQSATQPRP---- 599

  Fly   591 PEVLENQWRIHNTGWLTVASIMTAGCDILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSK 655
                .....:|:..|:...:.:..|.:....|..:|:...:||:|.:|:.:|||||||||||.|:
Mouse   600 ----SASATLHSAIWIVYGAFVQQGGESSVNSVAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSR 660

  Fly   656 MEGSIANLKDLSAQKKVKFGTIYGGSTYNLL-------ADSNETVYRLAFNLMNNDDPSAYTKDN 713
            |:..|...:|||.|.::.:||:...:.|...       .:.:.|...|...:..|........:.
Mouse   661 MDNPIRTFQDLSKQLEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVSNP 725

  Fly   714 LEGVDRVRKNRGDYMFLMETTTLEYH--REQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAI 776
            .||:.:.:|  |:|.||.:...:||.  .:.:|.:..:|.....|.|.||:..|:.||...|..|
Mouse   726 SEGIRKAKK--GNYAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRI 788

  Fly   777 LKLSERGELYDLKQKWWKNPNASCFEEPDPDAT----PDMTFEELRGIFYTLYAGILIAFLIGIT 837
            |:|.:.|:|..||||||  |:....:.....:|    ..:......|:|..|..|:|:|.|:...
Mouse   789 LELQDTGDLDVLKQKWW--PHTGRCDLTSHSSTQTEGKSLKLHSFAGVFCILAIGLLLACLVAAL 851

  Fly   838 E 838
            |
Mouse   852 E 852

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	Periplasmic_Binding_Protein_type1	26..409	CDD:471960	90/444 (20%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	115/383 (30%)
		Lig_chan	554..827	CDD:459656	77/288 (27%)
Grid1	NP_032192.2	Interaction with CBLN1. /evidence=ECO:0000269|PubMed:27418511	21..436		92/459 (20%)
		PBP1_iGluR_delta_1	25..425	CDD:380615	90/443 (20%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	116/388 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	931..960