Protein Alignment GluRIIC and Gria4

DIOPT Version :10

• Sequence 1: NP_608557.4
• Gene: GluRIIC / 33275
• FlyBaseID: FBgn0046113
• Length: 940
• Species: Drosophila melanogaster
• Sequence 2: XP_006509904.1
• Gene: Gria4 / 14802
• MGIID: 95811
• Length: 912
• Species: Mus musculus
• Alignment Length: 890
• Identity: 260/890 - (29%)
• Similarity: 404/890 - (45%)
• Gaps: 113/890 - (12%)

  Fly     3 QRILLLGCMW----SAFFMCRSRGQQINIGAFFYDDELELEKEFMTVVNAI----NGPE-SEQTM 58
            |.:||....|    .||      ...:.||..|..:   .::|:.....||    ..|. ||...
Mouse     7 QIVLLFSGFWGLAMGAF------PSSVQIGGLFIRN---TDQEYTAFRLAIFLHNTSPNASEAPF 62

  Fly    59 RFYPLIKRLKPEDGSVTMQEHACDLIDNGVAAIFGPSSKAASDIVALVCNSTGIPHIEFDISDEG 123
            ...|.:..::..: |..:....|.....||.||||...|.:...:...|::..|..|......||
Mouse    63 NLVPHVDNIETAN-SFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITPSFPTEG 126

  Fly   124 IQAEKPNHQMTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQ---LREVH 185
                  ..|..|.|.|:   |..|...::.::.|..|..:||.|  |..:.||.:::   ....|
Mouse   127 ------ESQFVLQLRPS---LRGALLSLLDHYEWNCFVFLYDTD--RGYSILQAIMEKAGQNGWH 180

  Fly   186 NDVVRVRKFHKDDDFRVMWKSI--RGERRVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNLET 248
            ...:.|..|: |..:|.:.:.:  |.|::.|:|||...|..:|......|...:..|..:.||..
Mouse   181 VSAICVENFN-DVSYRQLLEELDRRQEKKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIANLGF 244

  Fly   249 YTDHLEELAADNETFAVNITAARLLVNPDPPPYSL--PYGYVTQRDNIVYESSDPPRTLIHDLIH 311
            ....||.....    ..|:|..:|:....|....|  .:..:.||:   |..|:.|......|.:
Mouse   245 KDISLERFIHG----GANVTGFQLVDFNTPMVTKLMDRWKKLDQRE---YPGSETPPKYTSALTY 302

  Fly   312 DALQLFAQSWR-------------NASFFYPDRMVVPRITCDFAASGGRTWAMGRYLARLMKGT- 362
            |.:.:.|:::|             ||.              |..|:....|..|..:.|.:|..
Mouse   303 DGVLVMAETFRSLRRQKIDISRRGNAG--------------DCLANPAAPWGQGIDMERTLKQVR 353

  Fly   363 -SGVNNTNFRTSILQFDEDGQRITFNIEVYDPLDGIG---IAIWDPRGQIT------QLNVDVKA 417
             .|:      |..:|||..|:|:.:.::|:: |...|   :..|:...::.      .|..|..|
Mouse   354 IQGL------TGNVQFDHYGRRVNYTMDVFE-LKSTGPRKVGYWNDMDKLVLIQDAPTLGNDTAA 411

  Fly   418 QKKMIYRVATRIGPPYFSYNETARELNLTGNALYQGYAVDLIDAIARHVGFEYVFVPVADQQYGK 482
            .:.....|.|.:..||..|.:. .|: ..||..|:||.|||...||:|:|.:|....|.|.:||.
Mouse   412 IENRTVVVTTIMESPYVMYKKN-HEM-FEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGA 474

  Fly   483 LDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKTLDAY 547
            .|.:||.|||::||::...|.:.|..||||..|:..:||:.|||.||:||:..|....:..:.::
Mouse   475 RDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSF 539

  Fly   548 LAPFGGEVWIWIL---ISVFVMTFLKTIVARISKMDW--ENPH-----PCNRDPEVLENQWRIHN 602
            |.|...|:|:.|:   |.|.|:.||   |:|.|..:|  |.|.     |.::.|    |::.|.|
Mouse   540 LDPLAYEIWMCIVFAYIGVSVVLFL---VSRFSPYEWHTEEPEDGKEGPSDQPP----NEFGIFN 597

  Fly   603 TGWLTVASIMTAGCDILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLS 667
            :.|.::.:.|..||||.|||...|:....||.|.:||.:|||||||||||..:|...|.:.:||:
Mouse   598 SLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLA 662

  Fly   668 AQKKVKFGTIYGGSTYNLLADSNETVYRLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFLME 732
            .|.::.:||:..|||......|...||...:..|.:.:||.:|:...|||.||||::|.:.||:|
Mouse   663 KQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKFAFLLE 727

  Fly   733 TTTLEY-HREQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNP 796
            :|..|| .:.:.||...||.....|.|.:|.|.|:..|:.:::|:|||||.|.|..||.|||.:
Mouse   728 STMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVLKLSEAGVLDKLKNKWWYD- 791

  Fly   797 NASC--FEEPDPDATPDMTFEELRGIFYTLYAGILIAFLIGITEF 839
            ...|  .:....|.|..::...:.|:||.|..|:.:|.|:.:.||
Mouse   792 KGECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEF 836

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	Periplasmic_Binding_Protein_type1	26..409	CDD:471960	90/412 (22%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	148/381 (39%)
		Lig_chan	554..827	CDD:459656	106/285 (37%)
Gria4	XP_006509904.1	PBP1_iGluR_AMPA_GluR4	28..400	CDD:380611	90/415 (22%)
		PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	149/390 (38%)