DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIC and Gria2

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_001344853.2	Gene:	Gria2 / 14800	MGIID:	95809	Length:	901	Species:	Mus musculus

Alignment Length:	915	Identity:	261/915 - (28%)
Similarity:	423/915 - (46%)	Gaps:	120/915 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ILLLGCMWSAFFMCRSRGQQINIGAFF---YDDELELEKEFMTVVNAINGPESEQTMRFYPLIKR 66
            :||...:|...|...|  ..|.||..|   .|.|....:     |..:....||  .|..|.|..
Mouse     9 VLLSPVLWGLIFGVSS--NSIQIGGLFPRGADQEYSAFR-----VGMVQFSTSE--FRLTPHIDN 64

  Fly    67 LKPEDGSVTMQEHACDLIDNGVAAIFGPSSKAASDIVALVCNSTGIPHIEFDISDEGIQAEKPNH 131
            |:..: |..:....|.....||.||||...|.:.:.:...|.:..:..|......:|      .|
Mouse    65 LEVAN-SFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDG------TH 122

  Fly   132 QMTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLL-------------QLRE 183
            ...:.:.|.   |..|...:::.:.|.||..:||:|  |..:.||.:|             .:..
Mouse   123 PFVIQMRPD---LKGALLSLIEYYQWDKFAYLYDSD--RGLSTLQAVLDSAAEKKWQVTAINVGN 182

  Fly   184 VHNDVVRVRKFHKDDDFRVMWK--SIRGERRVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNL 246
            ::||       .||:.:|.:::  .::.||||:||||.:.:.::::.....|...:..|..:.||
Mouse   183 INND-------KKDETYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANL 240

  Fly   247 ETYTDHLEELAADNETFAVNITAARL----LVNPDPPPYSLPYGYVTQRDNIVYESSDP---PRT 304
             .:|        |.:...:....|.:    :|:.|.   ||...:: :|.:.:.|...|   ..|
Mouse   241 -GFT--------DGDLLKIQFGGANVSGFQIVDYDD---SLVSKFI-ERWSTLEEKEYPGAHTAT 292

  Fly   305 LIHD--LIHDALQLFAQSWRNASFFYPDRMVVPR--ITCDFAASGGRTWAMGRYLARLMK----- 360
            :.:.  |.:||:|:..:::||   ....|:.:.|  ...|..|:....|..|..:.|.:|
Mouse   293 IKYTSALTYDAVQVMTEAFRN---LRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVE 354

  Fly   361 GTSGVNNTNFRTSILQFDEDGQRITFNIEV-------------YDPLDGIGIAIWD-PRGQITQL 411
            |.||         .::||::|:||.:.|.:             :..:|.:.:.:.: |.|.
Mouse   355 GLSG---------NIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGN---- 406

  Fly   412 NVDVKAQKKMIYRVATRIGPPYFSYNETARELNLTGNALYQGYAVDLIDAIARHVGFEYVFVPVA 476
              |....:.....|.|.:..||....:. .|: |.||..|:||.|||...||:|.||:|....|.
Mouse   407 --DTSGLENKTVVVTTILESPYVMMKKN-HEM-LEGNERYEGYCVDLAAEIAKHCGFKYKLTIVG 467

  Fly   477 DQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVE 541
            |.:||..|.:||.|||::||::...|.:.|..||||..|:..:||:.|||.||:||:..|....:
Mouse   468 DGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSK 532

  Fly   542 KTLDAYLAPFGGEVWIWIL---ISVFVMTFLKTIVARISKMDWENPH-PCNRDPEVLE--NQWRI 600
            ..:.::|.|...|:|:.|:   |.|.|:.||   |:|.|..:|.... ...|:.:..|  |::.|
Mouse   533 PGVFSFLDPLAYEIWMCIVFAYIGVSVVLFL---VSRFSPYEWHTEEFEDGRETQSSESTNEFGI 594

  Fly   601 HNTGWLTVASIMTAGCDILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKD 665
            .|:.|.::.:.|..||||.|||...|:....||.|.:||.:|||||||||||..:|...|.:.:|
Mouse   595 FNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAED 659

  Fly   666 LSAQKKVKFGTIYGGSTYNLLADSNETVYRLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFL 730
            ||.|.::.:||:..|||......|...|:...:..|.:.:||.:.:...|||.||||::|.|.:|
Mouse   660 LSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYL 724

  Fly   731 METTTLEY-HREQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWK 794
            :|:|..|| .:.:.||...||.....|.|.||.|.|:..|:.:::|:|||||:|.|..||.|||.
Mouse   725 LESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWWY 789

  Fly   795 NP-NASCFEEPDPDATPDMTFEELRGIFYTLYAGILIAFLIGITEFLVYVQQVALEERLTFKDAF 858
            :. .....:....:.|..::...:.|:||.|..|:.:|.|:.:.||....:..|...::|...|.
Mouse   790 DKGECGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKMTLSAAT 854

  Fly   859 KKEIR 863
            :.:.|
Mouse   855 RNKAR 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	90/425 (21%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	21/95 (22%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	147/377 (39%)
		Lig_chan	554..828	CDD:278489	102/281 (36%)
Gria2	NP_001344853.2	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	90/420 (21%)
Gria2	NP_001344853.2	PBP2_iGluR_AMPA	413..794	CDD:270433	148/385 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846282
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.950