Protein Alignment GluRIIC and Nmdar1

DIOPT Version :10

• Sequence 1: NP_608557.4
• Gene: GluRIIC / 33275
• FlyBaseID: FBgn0046113
• Length: 940
• Species: Drosophila melanogaster
• Sequence 2: XP_321646.4
• Gene: Nmdar1 / 1281696
• VectorBaseID: AGAMI1_011915
• Length: 966
• Species: Anopheles gambiae
• Alignment Length: 1077
• Identity: 240/1077 - (22%)
• Similarity: 398/1077 - (36%)
• Gaps: 270/1077 - (25%)

  Fly     4 RILLLGCMW------SAFFMCRSRGQQ----INIGAFFYDDELELEKEFMTVVNAINGPES--EQ 56
            |:|...||.      .|....:..|.:    .|||....::  |.|..|.||:..:|..:.  .:
Mosquito     5 RMLPASCMLLSLMIPQALLAQKPTGSESPSYYNIGGVLSNN--ESESHFATVIAHLNFDQQYVPR 67

  Fly    57 TMRFYPLIKRLKPEDGSVTMQEHAC-DLIDNGVAAIFGPSSKAASDI-VALVCNSTG---IPHIE 116
            ...:|.  |.::.:...:....:.| .||...|.|:. .|.:...|: .|.|..::|   ||.|.
Mosquito    68 GTTYYD--KTIRIDKNPIKTALNVCKHLISRRVYAVV-VSHEPTGDLSPAAVSYTSGFYQIPVIG 129

  Fly   117 FDISDEGIQAEKPNHQMTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDAD-DARAA-ARLQDLL 179
            .. |.|...::|..|...|...|.....:..:.:|:.:||:.|..|::.:| |.||. .|.|...
Mosquito   130 IS-SREAAFSDKNIHVSFLRTVPPYYHQADVWLEILSHFGYTKVIIIHSSDTDGRAVLGRFQTTS 193

  Fly   180 QLREVHNDVVRVRKFHKDDDFRVMWKSIRGERRVVLDCEPNM---------------LVELLNSS 229
            |..            :.|.|.|...:||       ::.||.:               .|.||.:|
Mosquito   194 QTN------------YDDIDVRATVESI-------VEFEPKLDSFSSYLMDMKTAQSRVYLLYAS 239

  Fly   230 TE-----------FGLTGQYNHIFLTNLETYTDHLEELAADNETFAVNITAARLLVNPDPPPYSL 283
            .|           ..:| :|.||::..        |:..:.|.|
Mosquito   240 QEDAYVIFRDAAIHNMT-EYGHIWIVT--------EQALSANNT--------------------- 274

  Fly   284 PYGYVTQRDNIVYESSDPPRTLIHDLIHDALQLFAQSWRNASFFYPDRMVVPRIT-----CDFAA 343
            |.|.:..:.|.....:|      |  |.||:.:.|.:.:       :..|...||     ||
Mosquito   275 PTGIIGLKLNNAENETD------H--IKDAIYILASAIK-------EMTVNETITEAPKDCD--- 321

  Fly   344 SGGRTWAMGRYLARLMKGTSGVNNTNFRTSILQFDEDGQRI-----TFNIEVYDPLDGIGIAIWD 403
            ..|..|..|:.|...:|    ..|....|..:.||::|.|:     ..|:........:|...:|
Mosquito   322 DSGVIWESGKRLFGYLK----TRNIRGETGQVAFDDNGDRMYAEYDVINVHENHSFVKVGSFHYD 382

  Fly   404 ------------------------PRGQI--TQLNVDVKAQKKMIYR----------VATRIGPP 432
                                    |.|.:  |.|.|....:|..:|.          ....:..|
Mosquito   383 SEKRKMRLKINDSSITWPGNTGKKPEGIMIPTHLKVLTIEEKPFVYARKLLDDEIDCADDEVVCP 447

  Fly   433 YFSYNETARELNLT-GNA---LYQGYAVDLIDAIARHVGFEYVFVPVADQQYG--KLDKET---- 487
            :|         |:| ||.   ..:||.:||:.|:|:.:.|.|......|.|:|  :|...|
Mosquito   448 HF---------NITNGNEQEYCCKGYCIDLLKALAQRINFTYDLALSPDGQFGHYQLKNHTTGIG 503

  Fly   488 ----KQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKTLDAYL 548
                |:|||:|||::...|.:.:..|||...|...::|:.||...|::||. |.|....||.::|
Mosquito   504 TTVKKEWNGLIGELVAERADLIVAPLTINPERAEFIEFSKPFKYQGITILE-KKPSRSSTLVSFL 567

  Fly   549 APFGGEVWIWILISVFVMTFLKTIVARISKMDWENPHPCNR-----DPEVLENQWRIHNTGWLTV 608
            .||...:||.:::||.|:..:..::.|.|        |..|     .....|:...:.:..|...
Mosquito   568 QPFSNTLWILVMVSVHVVALVLYLLDRFS--------PFGRFKLSTTDGTEEDALNLSSAIWFAW 624

  Fly   609 ASIMTAGC-DILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDL---SAQ 669
            ..::.:|. :..|||...|:....|..||:||..||||||||||...:.:..:..:.|.   :..
Mosquito   625 GVLLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLTGINDARLRNTM 689

  Fly   670 KKVKFGTIYGGSTYNLLADSNETVYRLAFNLMN-NDDPSAYTKDNLEGVDRVRKNRGDYMFLMET 733
            :.:...|:.|.|.        :..:|....|.| .....|...|..|...:..|:.....|:.::
Mosquito   690 ENLTCATVKGSSV--------DMYFRRQVELSNMYRTMEANNYDTAEQAIQDVKDGKLMAFIWDS 746

  Fly   734 TTLEYHREQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNPNA 798
            :.|||...::|:|.:.||.||...|.:.:..|:.:...:::|||...|.|.:..|.::|..:.|.
Mosquito   747 SRLEYEASKDCELVTAGELFGRSGYGVGLQKGSPWTDAVTLAILDFHESGFMESLDKEWIFHGNV 811

  Fly   799 SCFEEPDPDATPD-MTFEELRGIFYTLYAGILIAFLIGITEFLVYVQQVALEERLTFKDAFKKEI 862
            ...|:  .:.||: :..:.:.|:|..:.|||:....:.|.|.:....|:        |...|.||
Mosquito   812 QQCEQ--FEKTPNTLGLKNMAGVFILVGAGIVGGIGLIIIEVVYKKHQI--------KKQKKMEI 866

  Fly   863 -RFVLCVW----NNRKPIVAGTPISSVRTTPRRSLDKS----------------LDRTPK----S 902
             |.....|    ..||.:.|...:.........|:.||                |.|||:    .
Mosquito   867 ARHAADKWRGTIEKRKTLRASLAMQRQYNVGLNSVSKSVQSQNAEKSRYPILPPLPRTPERAWPK 931

  Fly   903 SRRVVIGRSSEEMREMAQGSGSSSGSNNAGRGEKEAR 939
            .:..::.|.                :|::|.|:...|
Mosquito   932 DKEYIVNRK----------------NNSSGAGKPSPR 952

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	Periplasmic_Binding_Protein_type1	26..409	CDD:471960	91/453 (20%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	106/404 (26%)
		Lig_chan	554..827	CDD:459656	67/283 (24%)
Nmdar1	XP_321646.4	None