Protein Alignment GluRIIC and Nmdar2

DIOPT Version :10

• Sequence 1: NP_608557.4
• Gene: GluRIIC / 33275
• FlyBaseID: FBgn0046113
• Length: 940
• Species: Drosophila melanogaster
• Sequence 2: XP_061504088.1
• Gene: Nmdar2 / 1275196
• VectorBaseID: AGAMI1_003064
• Length: 910
• Species: Anopheles gambiae
• Alignment Length: 873
• Identity: 192/873 - (21%)
• Similarity: 346/873 - (39%)
• Gaps: 210/873 - (24%)

  Fly    92 FGPSSKAASDIVALVCNSTGIPHIEFDISDEGIQAEKPNHQMTLNLYPAQAILSKAYADIVQNFG 156
            :|.|:.:|...:.| ....|||.|.::..:.|::.......:.|.|.|:....|.|...|::.:.
Mosquito     7 YGRSTASAQYFLQL-AGYLGIPVISWNADNSGLERRASQSALQLQLAPSIEHQSAAMLSILERYK 70

  Fly   157 WRKFTIVYDA----DDARAAARLQ---------------------DLLQLREVHNDVVRVRKFHK 196
            |.:|::|...    ||...|.|.|                     |||:|
Mosquito    71 WHQFSVVTSQIAGHDDFVQAVREQVGAMDHFKFTILNSIIVTRPSDLLEL--------------- 120

  Fly   197 DDDFRVMWKSIRGERRV-VLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNLETYTDHLEELAADN 260
                      :..|.|| :|.|..:..:|:|:::.|..:||: |::::..        :.:..:.
Mosquito   121 ----------VNSEARVMLLYCTKSEAIEILHAAEELQITGE-NYVWVVT--------QSVIENT 166

  Fly   261 ETFAVNITAARLLVNPDPPPYSLPYGYVTQRDNIVYESSDPPRTLIHDLIHDALQLFAQSWRNAS 325
            :|            :|..|...|...:.|....:|.|            |..|::::|.   ...
Mosquito   167 QT------------HPQFPIGMLGVHFDTSSGALVNE------------IATAIRVYAY---GVE 204

  Fly   326 FFYPD------RMVVPRITCDFAASGGRTWAMGRYLARLMKGTSGVNNTNFRTSILQFDEDGQRI 384
            ::..|      |:...:::|:....|  .|..|....:.::..|..:.:|  ...::|..||...
Mosquito   205 YYLNDVKNTGRRLDTHQLSCEDQGRG--RWDSGEVFFKYLRNVSLESESN--KPNIEFTADGDLK 265

  Fly   385 TFNIEVYD---PLDGIGIAIWDPRG---QITQLNVDVK--------------AQKKMIYRVATRI 429
            :..:::.:   .::..|: :|:..|   ...|..:|::              ..:|...::....
Mosquito   266 SAELKIMNLRPSVNSKGL-VWEEIGIWKSWQQQKLDIRDIAWPGNSHTPPQGVPEKFHLKITFLE 329

  Fly   430 GPPYFSYN-----------------ETARELNLT---------GNALYQ---GYAVDLIDAIARH 465
            ..||.:.:                 ..|.:..:|         ..:.||   |:.:||::..|..
Mosquito   330 EAPYINLSPADPVSGKCLMDRGVLCRVAADHEMTDIDMGQAHKNGSFYQCCSGFCIDLLEKFAEE 394

  Fly   466 VGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQLGV 530
            :||.|..|.|.|.::|.|  |..:|||:|.|::|....|.:..|.|...|:..|||:.|||:.|:
Mosquito   395 LGFTYELVRVEDGKWGTL--ENGKWNGLIHELVNRKTDMVLTSLMINAEREAVVDFSEPFMETGI 457

  Fly   531 SILAYK-----SPHVEKTLDAYLAPFGGEVWIWILISVFVM---TFLKTIVARISKMDWENPHPC 587
            :|:..|     ||      .|:|.||  :...|:|:.:|.:   ||:      |...:|.:|...
Mosquito   458 AIVVAKRTGIISP------TAFLEPF--DTASWMLVGIFAIQAATFM------IFLFEWLSPSGY 508

  Fly   588 NRDPEVLEN------QWRIHNTGWLTVASIMTAGCDI-LPRSPQVRMFEATWWIFAIIIANSYTA 645
            :. ..||:|      ::.:..|.||..|.:..|...: .||....|.....|.:||::....|||
Mosquito   509 DM-KTVLQNGQTTPYRFSLFRTYWLVWAVLFQAAVHVDSPRGFTSRFMTNVWAMFAVVFLAIYTA 572

  Fly   646 NLAAFLTSSKMEGSIANLKD------LSAQKKVKFGTIYGGSTYNLLADSNETVYRLAFNLMNND 704
            |||||:.:.:.......|.|      .|.:..:|||||....|     ||..:.|   |..|:.
Mosquito   573 NLAAFMITREEFHEFTGLDDSRLSHPFSHKPTIKFGTIPWSHT-----DSTISKY---FKEMHY- 628

  Fly   705 DPSAYTKDNL-EGVDRVRKNRGDYMFLMETTTLEY--HREQNCDLRSVGEKFGEKHYAIAVPFGA 766
            ....|.:.:: :||..|...:.| .|:.:.|.|:|  .::::|.|.:||:.:....|.:|....:
Mosquito   629 YMKQYNRSSVADGVTAVLSGQLD-AFIYDGTVLDYLVQQDEDCRLLTVGQWYAMTGYGLAFSRNS 692

  Fly   767 EYRSNLSVAILKLSERGELYDLKQKWWK---NPNASCFEEPDPDATPDMTFEELRGIFYTLYAGI 828
            :|....:..:|:....|:|..|::.|..   .|.....:..||     :..|:....|..|.|||
Mosquito   693 KYVGMFNKRLLEFRANGDLERLRRFWMTGTCRPGKQEHKSSDP-----LALEQFLSAFLLLMAGI 752

  Fly   829 LIAFLIGITEFLVYVQQVALEERLTFKD 856
            |:|.|:.:.|.|.:..   ..:||..||
Mosquito   753 LLAALLLLLEHLYFKY---FRKRLAKKD 777

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	Periplasmic_Binding_Protein_type1	26..409	CDD:471960	62/354 (18%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	109/423 (26%)
		Lig_chan	554..827	CDD:459656	71/294 (24%)
Nmdar2	XP_061504088.1	None