Protein Alignment GluRIIC and GRIN3A

DIOPT Version :10

• Sequence 1: NP_608557.4
• Gene: GluRIIC / 33275
• FlyBaseID: FBgn0046113
• Length: 940
• Species: Drosophila melanogaster
• Sequence 2: NP_597702.2
• Gene: GRIN3A / 116443
• HGNCID: 16767
• Length: 1115
• Species: Homo sapiens
• Alignment Length: 1026
• Identity: 207/1026 - (20%)
• Similarity: 394/1026 - (38%)
• Gaps: 241/1026 - (23%)

  Fly    43 MTVVNAINGPESEQTMRFYPLIKRLKP-----EDGSVTMQEHACDLIDNGVAAIFG-PSSKAAS- 100
            :.||.||     |..:...||:....|     .|....:|.....::..||:|:.. |.|:...
Human   148 LEVVMAI-----EAGLGDLPLLPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMM 207

  Fly   101 --DIVALVCNSTGIPHIEFDISDEGIQAEKPNHQMTLNLYPAQAILSKAYADIVQNFGWRKFTIV 163
              |:|:||.:   ||.|.....:...:::.|.| :.|:|..:.:..:.....|:....|..|:::
Human   208 ELDLVSLVLH---IPVISIVRHEFPRESQNPLH-LQLSLENSLSSDADVTVSILTMNNWYNFSLL 268

  Fly   164 YDADDARAAARLQDLLQLREVHNDVVRVRKFH------------KDDD----FRVMWKSIRGERR 212
            ...:|    ..:.|.|.|.:.::      |||            ...|    .::..:||:....
Human   269 LCQED----WNITDFLLLTQNNS------KFHLGSIINITANLPSTQDLLSFLQIQLESIKNSTP 323

  Fly   213 --VVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNLETYTDHLEELAADNETFAVNITAARLLVN 275
              |:..|:...:..:...:|:||:........|.:    :.::|||..:
Human   324 TVVMFGCDMESIRRIFEITTQFGVMPPELRWVLGD----SQNVEELRTE---------------- 368

  Fly   276 PDPPPYSLPYGYVTQRDNIVYESSDPPRTLIHDLIHDALQLFAQSWRNASFFYPDRMVVP-RITC 339
                  .||.|.:..        ....:::....:.||::|.|::...|:...|:..::| .:.|
Human   369 ------GLPLGLIAH--------GKTTQSVFEHYVQDAMELVARAVATATMIQPELALIPSTMNC 419

  Fly   340 DFAASGGRTWAMGRYLARLM-----KGTSGVNNTNFRTSILQFDEDGQRITFNIEVYDPLDGIGI 399
            ....:...|  .|:||:|.:     :|.||.......|.:   ..:.....:|:: :||:   |.
Human   420 MEVETTNLT--SGQYLSRFLANTTFRGLSGSIRVKGSTIV---SSENNFFIWNLQ-HDPM---GK 475

  Fly   400 AIWDPRG--QITQLNVDV-----KAQK---------KMIYRVATRIGPPYFSYNET-------AR 441
            .:|...|  |..::.:|.     :||:         |:..||.|.|..|:....|.       |.
Human   476 PMWTRLGSWQGGKIVMDYGIWPEQAQRHKTHFQHPSKLHLRVVTLIEHPFVFTREVDDEGLCPAG 540

  Fly   442 ELNL--------TGNALYQ------------------GYAVDLIDAIARHVGFEYVFVPVADQQY 480
            :|.|        |.::|:.                  ||.:||::.||..:.|::....|.|.:|
Human   541 QLCLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEKIAEDMNFDFDLYIVGDGKY 605

  Fly   481 GKLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKTLD 545
            |..  :...|.|::|:::...|||.:...:|..||...:|||.||....:.||. ::......:.
Human   606 GAW--KNGHWTGLVGDLLRGTAHMAVTSFSINTARSQVIDFTSPFFSTSLGILV-RTRDTAAPIG 667

  Fly   546 AYLAPFGGEVWIWILISVFVMTFLKTIVARISKMDWENPH---PCNRDPEVLENQWRIHN-TGWL 606
            |::.|....:|:.|.:::.:.....|:      .:|::|.   |..|      |:.::.: :..|
Human   668 AFMWPLHWTMWLGIFVALHITAVFLTL------YEWKSPFGLTPKGR------NRSKVFSFSSAL 720

  Fly   607 TVASIMTAGCDILPRSPQV---RMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLS- 667
            .:...:..|..:..:.|:.   |.....|.||.:...::|||||||.:...|:...::.:.|..
Human   721 NICYALLFGRTVAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKL 785

  Fly   668 --AQKKVKFGTIYGGSTYNLLADSNETV--YRLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYM 728
              ..:..:|||:...|..:.:..|...:  |...:|:....|...|.|::.|.:|         .
Human   786 HHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVEYLKNDPEKLD---------A 841

  Fly   729 FLMETTTLEYH--REQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQK 791
            |:|:...|:|.  .:.:|.|.:||:.|..:.|.|.:|..:...:|:|..|.:....|.:..|..|
Human   842 FIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDK 906

  Fly   792 WWK----NPNASCFEEPDPDATPDMTFEELRGIFYTLYAGILIAFLIGITEFLVY---VQQVALE 849
            |::    ...:....|     |..|..:...|:|..|..|..::.|..|.|.:||   :.::..:
Human   907 WYRVVPCGKRSFAVTE-----TLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLLPRIKNK 966

  Fly   850 ERLTF------------KDAF--KKEIRF--------------VLCVWN-------NRKPIV--- 876
            .:|.:            ..:|  :|:..|              .|.|||       ||:..:
Human   967 SKLQYWLHTSQRLHRAINTSFIEEKQQHFKTKRVEKRSNVGPRQLTVWNTSNLSHDNRRKYIFSD 1031

  Fly   877 ------AGTPI-SSVRTTPRRSLDKSLDRTPKSSRRVVIGRSS--EEMREM 918
                  .|..| ..:...|||....:|..|...:..:.:.|:|  :|:.|:
Human  1032 EEGQNQLGIRIHQDIPLPPRRRELPALRTTNGKADSLNVSRNSVMQELSEL 1082

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	Periplasmic_Binding_Protein_type1	26..409	CDD:471960	75/400 (19%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	95/417 (23%)
		Lig_chan	554..827	CDD:459656	61/290 (21%)
GRIN3A	NP_597702.2	PBP1_iGluR_NMDA_NR3	40..496	CDD:380600	76/409 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	59..118
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	95/419 (23%)
		Lig_chan	674..941	CDD:459656	61/292 (21%)
		PPP2CB binding site. /evidence=ECO:0000250|UniProtKB:Q9R1M7	951..987		4/35 (11%)
		GIT1-binding. /evidence=ECO:0000250|UniProtKB:Q9R1M7	1062..1095		4/21 (19%)