DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIC and grik5

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	XP_002936446.1	Gene:	grik5 / 100497490	XenbaseID:	XB-GENE-953974	Length:	995	Species:	Xenopus tropicalis

Alignment Length:	875	Identity:	257/875 - (29%)
Similarity:	422/875 - (48%)	Gaps:	85/875 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 EDGSVTMQEHACDLIDNGVAAIFGPS-SKAASDIVALVCNSTGIPHIEFDISDEGIQAEKPNHQ- 132
            :|......:..|.::..||.::.||| |.|::..|:.:|....||||:  :..|    |.|..|
Frog    76 KDSQYETTDTMCQILPKGVVSVLGPSTSPASASTVSHICGEKEIPHIK--VGPE----EAPKLQY 134

  Fly   133 ---MTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQLREVHNDVVRVRKF 194
               .:::|||:...:|.|.:.|:::|.....:::  ...|....||::|::...:..|.:.||..
Frog   135 LRFASVSLYPSNEDISLAVSHILKSFHNPSTSLI--CAKAECLLRLEELVRQFLISKDTLSVRML 197

  Fly   195 HKDDDFRVMWKSIRGER--RVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNLETYTDHLEELA 257
            .:.:|...:.|.||.::  .:::|....:...:|..::|.|:|..:....||.::.....||.:.
Frog   198 DESNDPTPLLKEIRDDKVSTIIIDANATVSHLILKKASELGMTSAHYKYILTTMDFPLLSLEGIV 262

  Fly   258 ADNETFAVNITAARLLVNPDPPPY-----SLPYGYVTQRDNIVYESSDPPRTLIHDLIHDALQLF 317
            :|..    ||.... :.|...|.|     ||...:   |:|....:...| .|...|:.||:.:.
Frog   263 SDQS----NILGFS-MYNSSHPFYLEFLRSLNMSW---RENCELSTYLGP-ALSAALMFDAVHVV 318

  Fly   318 AQSWR--NASFFYPDRMVVPRITCDFAASGGRTWAMGRYLARLMKGT--SGVNNTNFRTSILQFD 378
            ..:.|  |.|    ..:.|.:::|    |..:.|..|..|...::..  .|:      |..::|:
Frog   319 VSAVRELNRS----QEIGVKQLSC----STSQIWQHGTSLMNYLRMVEYDGL------TGRVEFN 369

  Fly   379 EDGQRITFNIEVYDPLDGIG---IAIWDPRGQI----TQLNV---DVKAQKKMIYRVATRIGPPY 433
            ..|||..:.:.:.:.. |.|   |.:|.....:    |.|::   :....|.::  |.|.:..||
Frog   370 SKGQRTNYTLRILEKA-GDGHREIGVWYSNRTLAMNATSLDLSTSETLENKTLV--VTTILENPY 431

  Fly   434 FSYNETARELNLTGNALYQGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEII 498
            .......|  :|:||..|:|:..:::..:|..:.|.|....|.|..|| ..:....|.|::||:|
Frog   432 MMRKSNYR--SLSGNDQYEGFCAEMLMELAALLRFNYKIKLVEDGLYG-APEPNGSWTGMVGELI 493

  Fly   499 NNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKTLDAYLAPFGGEVWIWILISV 563
            |..|.:.:...|||..|:..:||:.|||.||:|||.......:....::|.||...||:::|::.
Frog   494 NRKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVQMGRKPGYFSFLDPFSPAVWLFMLLAY 558

  Fly   564 FVMTFLKTIVARISKMDWENPHPCNRD-PEVLENQWRIHNTGWLTVASIMTAGCDILPRSPQVRM 627
            ..::.:..:.||:|..:|.|||||.|: ..:||||:.:.|:.|..|...|..|.:::||:...|.
Frog   559 LAVSCVLFLAARLSPYEWYNPHPCLRERHHILENQYTLGNSLWFPVGGFMQQGSEVMPRALSTRC 623

  Fly   628 FEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLSAQKKVKFGTIYGGSTYNLLADSNET 692
            ....||.|.:||.:|||||||||||..:||..|.:..||:.|..:::|||:||||.....:|...
Frog   624 VSGVWWAFTLIIISSYTANLAAFLTVQRMEVPIESADDLADQTNIEYGTIHGGSTMTFFQNSRYQ 688

  Fly   693 VYRLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFLMETTTLEYHREQNCDLRSVGEKFGEKH 757
            .|:..:|.||:..||.:.|...||:.||..:|  |.||:|:|..||||..||:|..:|.....|.
Frog   689 TYQRMWNYMNSKQPSVFVKSTEEGIARVLNSR--YAFLLESTMNEYHRRLNCNLTQIGGLLDTKG 751

  Fly   758 YAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNPNASCFEEPDPDATPDMTFEELRGIFY 822
            |.|.:|.|:.||..:::|||:|.|...|..||:|||:  ...|.:|.|..| ..:..|.:.|||.
Frog   752 YGIGMPLGSPYRDEITLAILQLQENNRLEILKRKWWE--GGKCPKEEDHRA-KGLGMENIGGIFV 813

  Fly   823 TLYAGILIAFLIGITEFLVYVQQVALEERLTFKDAFKKEIR-FVLCVWNNRKPIVAGTPISSVRT 886
            .|..|::||..:.|.||:...::....|.::.......|:| .|.|...:|         |..|.
Frog   814 VLICGLIIAVFVAIMEFVWSTRRSVDNEEISVCQEMLSELRSAVSCKKTSR---------SRHRR 869

  Fly   887 TPRRSLD----KSLDRTPKSSR--RVVIGR 910
            .|.|.|.    .||.|.|:|:|  |:..||
Frog   870 RPPRHLHGRTLLSLSRPPRSTRETRLCNGR 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	80/352 (23%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	20/92 (22%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	138/371 (37%)
		Lig_chan	554..828	CDD:278489	107/274 (39%)
grik5	XP_002936446.1	PBP1_iGluR_Kainate_KA1_2	27..405	CDD:380616	80/360 (22%)
grik5	XP_002936446.1	Periplasmic_Binding_Protein_Type_2	418..788	CDD:389745	139/376 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.930