DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIC and grin3b

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	XP_017952374.2	Gene:	grin3b / 100497172	XenbaseID:	XB-GENE-990106	Length:	1005	Species:	Xenopus tropicalis

Alignment Length:	1002	Identity:	202/1002 - (20%)
Similarity:	362/1002 - (36%)	Gaps:	267/1002 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 PEDGS-VTMQEHACD-LIDNGVAAIFGPSSKAASDIVAL--VCNSTGIPHIEFDISDEGI---QA 126
            |.|.| .::....|. |:..|:||:.. ..:|..:::.|  :.:...||.|.. :..|.|   ..
Frog    79 PRDRSPASLTRWLCQVLVAQGIAAVLA-FPQAQEELLQLEFLSSFLEIPFISI-LEQEQIVPLAT 141

  Fly   127 EKPNHQMTLNLYPAQAILSKAYADIVQNFGWRKFTIV--YDADDARAAARL--------QDLLQL 181
            :.|.| :.::...:...|...:..::||..|.:..|:  :..|.|.....|        :.:|.:
Frog   142 KNPFH-LQMDTQSSVENLMDIFFSVLQNSSWEEVDIITCHPWDSASIQRYLTSNTTLVSRTILNI 205

  Fly   182 REV-HNDVVRVRKFH----KDDDFRVMWKSIRGER-----RVVLDCEPNMLVELLNSSTEFGLTG 236
            ..| .:.:|...:.|    |:..|.::.......|     ||..||
Frog   206 HPVDESALVPFLQQHFESMKNPQFPMLLYGCDARRSSLVFRVARDC------------------- 251

  Fly   237 QYNHIFLTNLETYTDHL--------EELAADNETFAVNITAARLLVNPDPPPYSLPYGYVTQRDN 293
                    .||.:..|.        ||:..:.                 .||..|.||.|:
Frog   252 --------GLEAHEFHWMIGHPLNGEEMTTEG-----------------MPPGLLAYGEVS---- 287

  Fly   294 IVYESSDPPRTLIHDLIHDALQLFAQSWRNASFFYPD-RMVVPRITCDFAASGGRTWAMGRYLAR 357
                     |..:...|.||:.|..::...|....|| .::...:.|:...: .:..:.|.||:|
Frog   288 ---------RPTMEKFIRDAVGLVTRAISAAVHVRPDLALIQSMVNCNDKQT-KQNESSGSYLSR 342

  Fly   358 LMKGT--SGVNNTNFRTSILQFDEDGQRITFNIEVYDPLDGIGIAIWDPRGQITQLNVDVK---- 416
            .:..|  ||.....:.::.|...|...||...:.     |.:|...|...|...|..::|:
Frog   343 FLANTSFSGQTGQIYVSNNLIHTEHHYRIWSLVR-----DSLGDPTWVTVGGWRQGKMEVEEGLW 402

  Fly   417 --------------AQKKMIYRVATRIGPPYFSYNET--------------------------AR 441
                          |:.|:  ||.|.:..|:....|.                          ..
Frog   403 QSRIQQWEPAPGGFARTKL--RVVTLVEHPFVFTREVDADGSCPAGQMCLDPRTNNSAVLDVLFE 465

  Fly   442 ELNLTGNAL---YQ----GYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIIN 499
            |||....::   |:    ||.:||::.::..:.|::....|.|.:||.  ::..:|.|::|::::
Frog   466 ELNSPNGSVPLEYKTCCYGYCIDLLEKLSEDLRFDFELYIVGDGKYGA--RKGDRWTGLVGDLLS 528

  Fly   500 NDAHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKTLDAYLAPFGGEVWIWILISVF 564
            ..|||.:...:|..||.|.:|||.||....:.||. :.......:.|::.|....:|:.|.:::.
Frog   529 GAAHMAVTSFSINSARSTVIDFTSPFYSTSLGILV-RMRDTASPIGAFMWPLHWSMWVGIFVALH 592

  Fly   565 VMTFLKTIVARISKMDWENPH---PCNRDPEVLENQWRIHN-TGWLTVASIMTAGCDILPRSPQV 625
            :.....|.      .:|::|.   |..|      |:.:|.: :..|.:...:..|..:..::|:.
Frog   593 ITALFLTF------YEWKSPFGMTPHGR------NRTKIFSYSSALNLCYAILFGRTVSSKTPKC 645

  Fly   626 ---RMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLS---AQKKVKFGTIYGGSTYN 684
               |:....|.||.:::.:||||||||.:...|...:::.:.|..   ..:..:|||::..|.
Frog   646 CTGRVLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEALSGIHDPKLHHPSQGFRFGTVWESSA-- 708

  Fly   685 LLADSNETVYRLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDY-MFLMETTTLEYH--REQNCDL 746
                  |...:.:|..|:|...........:||..::.:.... .|:|:...|:|.  .:.:|.|
Frog   709 ------EQYIKKSFPEMHNYMRKFSVPATSDGVHLLKTDPPTLNAFIMDKALLDYEVSIDSDCKL 767

  Fly   747 RSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWK----NPNASCFEEPDPD 807
            .::|:.|..:.|.|.:|..:...||:|..|.:....|.:..|..||:|    ........|
Frog   768 LTIGKPFAIEGYGIGLPQNSPLTSNISEFISRYKSSGFMDTLHDKWYKMVPCGKRVYAVTE---- 828

  Fly   808 ATPDMTFEELRGIFYTLYAGILIAFLIGITEFLVY------------------------------ 842
             |..|......|:|..|..|...:.|..:.|.:||
Frog   829 -TLQMGIYHFSGLFVLLCIGFCGSLLTSLMERVVYHLILPRIRRRRRFKYWLHTSQKIHRALNMT 892

  Fly   843 -VQQVALEERLTFKDAFKKEIRFV-LCVWNNRKPIVAGTPISSVRTTP----RR---SLDKSLDR 898
             ..|.||..:|..:...:|:.... ..||||            :|.||    ||   :|:|:..|
Frog   893 CEDQDALSPKLNKRCNLQKDATGAPQSVWNN------------LRRTPAHQERRVHFNLEKASAR 945

  Fly   899 -------TPKSSRRVVIGRSSEEMREM 918
                   .||       |...||::|:
Frog   946 EGLCENGRPK-------GIKQEELKEL 965

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	70/372 (19%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	20/86 (23%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	92/416 (22%)
		Lig_chan	554..828	CDD:278489	62/290 (21%)
grin3b	XP_017952374.2	PBP1_iGluR_NMDA_NR3	29..402	CDD:380600	73/388 (19%)
		PBP2_iGluR_NMDA_Nr3	418..814	CDD:270438	92/420 (22%)
		Lig_chan	582..848	CDD:395014	62/290 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910