Protein Alignment GluRIIC and grin2d

DIOPT Version :10

• Sequence 1: NP_608557.4
• Gene: GluRIIC / 33275
• FlyBaseID: FBgn0046113
• Length: 940
• Species: Drosophila melanogaster
• Sequence 2: XP_031762459.1
• Gene: grin2d / 100496465
• XenbaseID: XB-GENE-1011863
• Length: 1345
• Species: Xenopus tropicalis
• Alignment Length: 964
• Identity: 195/964 - (20%)
• Similarity: 365/964 - (37%)
• Gaps: 216/964 - (22%)

  Fly    52 PESEQTMRFYPLIKR---LKPEDGSVTMQE--------HACDLID----NGVAAIFGPSSKAASD 101
            |||   .||.|...|   ::....||.:.:        ..||::.    :||.......:::.:.
 Frog    53 PES---ARFAPTTFRNFSMEVNPISVILNDTNPRSLILQICDVLSSLRIHGVVFEDDTRTESVAQ 114

  Fly   102 IVALVCNSTGIPHIEFDISDEGIQAEKPNHQMTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDA 166
            |:..:...|.:|.|..:.....:...|......|.|..:.....:...::::.:.|..|.::
 Frog   115 ILDFISAQTSMPIIGINGGSAIVLTPKEKGSTFLQLGASTEQQLQVIFEVLEEYDWTSFAVI--- 176

  Fly   167 DDARAAARLQDLLQLREVHNDVVRVRKFHKDDDFRVMWKSIRGERRVVLDCEPN----------- 220
                        ..|...:.|.|...:...|..| :.|:: ||...:.|..:|:
 Frog   177 ------------TTLFPGYEDFVDYIELLTDSSF-IGWEN-RGVLTLNLTDDPSGSKLKRQLREI 227

  Fly   221 -MLVELL-----------NSSTEFGLTGQYNHIFL--TNLETYTDHLEELAADNETFAVNITAAR 271
             ..|.||           .::.|.||||.....|:  |||.. ||::
 Frog   228 TAQVRLLYCSREEADGVFKAAREAGLTGPGYIWFMVGTNLGG-TDYM------------------ 273

  Fly   272 LLVNPDPPPYSLPYGYVT-----QRDNIVYESSDPPRTLIHDLIHDALQLFAQSWRNASFFYPDR 331
                    |..||.|..|     .:|:            :|..:.:.:.:.|   :.|...|.|.
 Frog   274 --------PEHLPVGLFTVLSAGWKDD------------LHRRVQNGVAIIA---KGAEALYKDF 315

  Fly   332 MVVPRITCDFAASGGRTWAMGRYLARLMKGTSGVNNTNFRTSILQFDEDGQRITFNIEVY--DPL 394
            ..:|....|..|..         |..:        |.|.....:.....|:..:||.:.|  :|.
 Frog   316 GFIPEFNNDCRAPN---------LTHM--------NENLHRYFMNISWGGKDFSFNEDGYLINPA 363

  Fly   395 ------------DGIGI----------AIWDPRGQITQ-----LNVDVKAQKKMIYRVATRIGPP 432
                        :.:||          .:|...|:..|     .::.|...::..:.:...:.|.
 Frog   364 LVVIALNKERSWEVVGIWEHGDLRMKYPVWSRYGKFLQPVDDDQHLTVATLEERPFVIVEGVDPA 428

  Fly   433 YFSYNETA----RELNLTGNAL----------YQGYAVDLIDAIARHVGFEYVFVPVADQQYGKL 483
            ..:....:    ::||.|.|.|          .:|:.:|::..:::.:||.|....|.:.::||
 Frog   429 TGTCIRDSVPCRKQLNRTDNHLTDPIIFVKQCCKGFCIDILKRLSKTIGFTYDLYLVTNGKHGK- 492

  Fly   484 DKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKTLDAYL 548
             |....|||:|||:....|.|.|..|||.:.|...:||:|||::.|:|::..:| :...:..|:|
 Frog   493 -KIDGVWNGMIGEVFYQRADMAIGSLTINEERSEIIDFSVPFVETGISVMVSRS-NGTVSPSAFL 555

  Fly   549 APFGGEVWIWILISVFVMTFLKTIVARISKMDWENPHPCNRDPEVLE----NQWRIHNTGWLTVA 609
            .|:...||    :.:|||. |..:...:...::.:|...||.....:    :::.|..:.||..|
 Frog   556 EPYSPAVW----VMMFVMC-LTVVAVTVFIFEYFSPVGYNRSLSTGKRPGGSKFTIGKSIWLLWA 615

  Fly   610 SIMTAGCDI-LPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLSAQK--- 670
            .:......: .|:....::....|..||:|...|||||||||:...:...:::.|.|...|:
 Frog   616 LVFNNSVPVENPKGTTSKIMVLIWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDKKFQRPHE 680

  Fly   671 ---KVKFGTIYGGSTYNLLADS--NETVYRLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFL 730
               .:||||:..|||...:..:  :...|.:.:|..:.:|          .:..::..:.| .|:
 Frog   681 QYPPLKFGTVPNGSTEKNIRSNYPDMHAYMIKYNQRHVED----------ALQNLKTGKLD-AFI 734

  Fly   731 METTTLEY--HREQNCDLRSV--GEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQK 791
            .:...|.|  .:::.|.|.::  |:.|....|.||:..|::::..:.:|:|:.....|:..|::.
 Frog   735 YDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALQKGSKWKRPIDLALLQFLGDDEIEMLERL 799

  Fly   792 WWKNPNASCFEEPDPDATPDMTFEELRGIFYTLYAGILIAFLIGITEFLVYVQQ---VALEERLT 853
            |.   :..|..:.....:..:..:.:.|:||.|...:.::.|:...|.|:|.:.   :....:|.
 Frog   800 WL---SGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLIYWKLRHCMRHSGKLD 861

  Fly   854 FKDAFKKEIRFVLCVWNNRKPIVAGTPISSVRTTPRRSLDKSLDRTPKSSRRVV 907
            |..||.:.: :..|      ...|..|.|||...|..|............||||
 Frog   862 FLLAFSRGM-YSCC------SAEAALPNSSVPPPPLPSAPLPCSNFIPRERRVV 908

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	Periplasmic_Binding_Protein_type1	26..409	CDD:471960	72/425 (17%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	96/401 (24%)
		Lig_chan	554..827	CDD:459656	62/289 (21%)
grin2d	XP_031762459.1	PBP1_iGluR_NMDA_NR2	38..390	CDD:380601	70/415 (17%)
		PBP2_iGluR_NMDA_Nr2	406..807	CDD:270436	98/422 (23%)
		NMDAR2_C	844..>873	CDD:463148	6/29 (21%)