DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIC and grik2

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	XP_017949808.1	Gene:	grik2 / 100495093	XenbaseID:	XB-GENE-5902331	Length:	913	Species:	Xenopus tropicalis

Alignment Length:	891	Identity:	270/891 - (30%)
Similarity:	449/891 - (50%)	Gaps:	107/891 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 EKEFMTVVNAINGPES--EQTMRFYPLIKRLKPEDGSVTMQEHACDLIDNGVAAIFGPSSKAASD 101
            |..|...||.||...:  ..|...|. .:|:...| |......||:.:..|||||||||..::::
Frog    59 ELAFRFAVNTINRNRTLLPNTTLTYD-TQRINLYD-SFEASRKACEQLSLGVAAIFGPSHSSSAN 121

  Fly   102 IVALVCNSTGIPHIE----FDISDEGIQAEKPNHQMTLNLYPAQAILSKAYADIVQNFGWRKFTI 162
            .|..:||:.|:|||:    ..:||.       .....::|||..:.||:|..|:||.|.|:..||
Frog   122 AVQSICNALGVPHIQTRWKHQVSDN-------KDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTI 179

  Fly   163 VYDADDARAAARLQDLLQLREVHNDVVRVRKFHKD-DDFRVMWKSI-RG-ERRVVLDCEPNMLVE 224
            .|  ||:....|||:|::....:|..:::|:...| .|.:.:.|.: || |..|:.||..:|...
Frog   180 AY--DDSTGLIRLQELIKAPSRYNLRLKIRQLPIDTKDAKPLLKEMKRGKEFHVIFDCSHDMAAG 242

  Fly   225 LLNSSTEFGLTGQYNHIFLTNLETYTDHLEELAADNETF---AVNITAARL-------------- 272
            :|..:...|:..:|.|...|.|:.:       |.|.|.:   .||:|..|:
Frog   243 ILKQALAMGMMTEYYHYIFTTLDLF-------ALDVEPYRYSGVNMTGFRILNIENSQVLSIIEK 300

  Fly   273 -----LVNPDPPPYSLPYGYVTQRDNIVYESSDPPRTLIHDLIHDALQLFAQSWRNASFFYPDRM 332
                 |..|..|...|..|::|....::|::       :| ::..|:|.|.|            |
Frog   301 WSMERLQAPPKPDSGLLDGFMTTDAALMYDA-------VH-VVSVAVQQFPQ------------M 345

  Fly   333 VVPRITCDFAASGGRTWAMGRYLARLMK-----GTSG---VNNTN-----FRTSILQFDEDGQRI 384
            .|..:.|    :..:.|..|.....|:|     |.:|   .|.||     |...::...|:|..
Frog   346 TVSSLQC----NRHKPWRFGARFISLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLE- 405

  Fly   385 TFNIEVYDPLDGIGIAIWDPRGQITQLNVDVKAQKKMIYRVATRIGPPYFSYNETARELNLTGNA 449
              .|..:||..|:.:. .:.:|:...: .|..:.:.:|  |.|.:..||..:.::.:.  |.|.|
Frog   406 --KIGTWDPTSGLNMT-ENQKGKPANI-TDSLSNRSLI--VTTILEEPYVMFKKSDKP--LYGKA 462

  Fly   450 LYQGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQA 514
            .::||.:||::.:::.:||||....|.|.:||..|..|:||||::.|::::.|.:.:..|.||..
Frog   463 RFEGYCIDLLEKLSKILGFEYEVRLVEDGKYGAKDDTTQQWNGMVRELMDHKADLAVAPLAITYV 527

  Fly   515 RKTAVDFTVPFMQLGVSILAYKSPH-VEKTLDAYLAPFGGEVWIWILISVFVMTFLKTIVARISK 578
            |:..:|||.|||.||:||| |:.|: ....:.::|.|...::|::||::...::.:..::||.|.
Frog   528 REQVIDFTKPFMTLGISIL-YRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSP 591

  Fly   579 MDWENPHPCNRDPEVLENQWRIHNTGWLTVASIMTAGCDILPRSPQVRMFEATWWIFAIIIANSY 643
            .:|.||||||.|.:|:||.:.:.|:.|..|.::|..|.:::|::...|:....||.|.:||.:||
Frog   592 YEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSY 656

  Fly   644 TANLAAFLTSSKMEGSIANLKDLSAQKKVKFGTIYGGSTYNLLADSNETVYRLAFNLMNNDDPSA 708
            |||||||||..:||..|.:..||:.|.|:::|.:..|:|......|....|...:..||:...|.
Frog   657 TANLAAFLTVERMESPIDSADDLAKQTKIEYGAVQDGATMTFFKKSRIPTYEKMWAFMNSRSQSV 721

  Fly   709 YTKDNLEGVDRVRKNRGDYMFLMETTTLEYHREQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLS 773
            ..|:|.||:.||..:  ||.||||:||:|:..::||:|..:|.....|.|.:..|.|:.||..::
Frog   722 LVKNNEEGIQRVLTS--DYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKIT 784

  Fly   774 VAILKLSERGELYDLKQKWWKNPNASCFEEPDPDATPDMTFEELRGIFYTLYAGILIAFLIGITE 838
            :|||:|.|.|.|:.:|:|||:  ...|.||...:|:. :..:.:.|||..|.||::::..:.:.|
Frog   785 IAILQLQEEGVLHMMKEKWWR--GNGCPEEESKEASA-LGVQNIGGIFIVLAAGLVLSVFVAVGE 846

  Fly   839 FLVYVQQVALEERLTFKDAFKKEIRFVLCVWNNRK-----PIVAGT 879
            ||...::.|..|:.:|..|..:|:|..|......|     |::..|
Frog   847 FLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQPPVIVKT 892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	107/408 (26%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	18/88 (20%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	136/371 (37%)
		Lig_chan	554..828	CDD:278489	100/273 (37%)
grik2	XP_017949808.1	PBP1_iGluR_Kainate	42..419	CDD:380605	107/404 (26%)
grik2	XP_017949808.1	Periplasmic_Binding_Protein_Type_2	435..805	CDD:419667	137/376 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010