DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIC and grik1

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	XP_004912220.1	Gene:	grik1 / 100493949	XenbaseID:	XB-GENE-957124	Length:	928	Species:	Xenopus tropicalis

Alignment Length:	953	Identity:	273/953 - (28%)
Similarity:	467/953 - (49%)	Gaps:	128/953 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 FMC-------RSRGQQINIGAFFYDDELE----LEKEFMTVVNAINGPES--EQTMRFYPLIKRL 67
            |:|       ::..|.:.||..|...|.|    .|..|...|..||...:  ..|...|. |:|:
Frog    29 FLCALAAITPQASQQVLRIGGIFETVENEPINVEELAFKFAVTNINRNRTLMPNTTLTYD-IQRI 92

  Fly    68 KPEDGSVTMQEHACDLIDNGVAAIFGPSSKAASDIVALVCNSTGIPHIEFDISDEGIQAEKPNHQ 132
            ...| |......|||.:..||||:||||..::...|..:||:..:|||:.......:..:   ..
Frog    93 NLFD-SFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNK---DS 153

  Fly   133 MTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQLREVHNDVVRVRKFHK- 196
            ..:||:|..|.:|:|..::|.::.|:..|:||  :|:....|||:|::....:|..:::|:...
Frog   154 FFINLHPDYAAISRAVLELVLHYSWKTVTVVY--EDSTGLIRLQELIKAPSRYNIKIKIRQLPSG 216

  Fly   197 DDDFRVMWKSIRGERR--VVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNLETYTDHLEELAAD 259
            :.|.|.:.|.::..|.  |:.||......|:|......|:..:|.|.|.|.::.:       |.|
Frog   217 NKDARTLLKEMKKSREFYVIFDCSHETAAEILKQILSMGMMTEYYHYFFTTMDLF-------ALD 274

  Fly   260 NETF---AVNITAARLLVNPDPPPYSLPYGYVTQRDNIVYESSDPPRTLIHD--------LIHDA 313
            .|.:   .||:|..|||...:|...|:...:..:|    .::...|.|.:.|        |::||
Frog   275 LEPYRYSGVNMTGFRLLNIDNPQVSSVVEKWSMER----LQAPPKPETGLLDGMMTTDAALMYDA 335

  Fly   314 LQLFAQSWRNASFFYPDRMVVPRITCDFAASGGRTWAMGRYLARLMK-----GTSG---VNNT-- 368
            :.:.|.:.:.|:     :|.|..:.|    ...:.|..|.....|:|     |.:|   .|.|
Frog   336 VYMVAVATQRAT-----QMTVSSLQC----HRHKPWRFGPRFMSLIKEARWDGLTGRITFNRTDG 391

  Fly   369 ---NFRTSILQFDEDGQRITFNIEVYDPLDGI--GIAIWDPRGQITQLNV------------DVK 416
               :|...|:...|||...... |..:.|:.:  .:.:|:..   |.||:            |..
Frog   392 LRRDFDMDIISLKEDGMEKAAG-ETVNHLNKVWKKVGVWNSN---TGLNMTDNLKDKSTNITDSL 452

  Fly   417 AQKKMIYRVATRIGPPYFSYNETARELNLTGNALYQGYAVDLIDAIARHVGFEYVFVPVADQQYG 481
            |.:.:|  |.|.:..||..:.::.:.  |.||..::||.:||:..::..:||.|....|.|.:||
Frog   453 ANRTLI--VTTILEDPYVMFRKSDKP--LYGNDRFEGYCLDLLKELSNILGFTYEVRLVVDGKYG 513

  Fly   482 KLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPH-VEKTLD 545
             ...:..:|||::.|:|::.|.:.:..||||..|:..:||:.|||.||:||| |:.|: ....:.
Frog   514 -AQNDKGEWNGMVRELIDHKADLAVAPLTITYVREKVIDFSKPFMTLGISIL-YRKPNGTNPGVF 576

  Fly   546 AYLAPFGGEVWIWILISVFVMTFLKTIVARISKMDWENPHPCNRDPEVLENQWRIHNTGWLTVAS 610
            ::|.|...::|:::|::...::.:..::||.:..:|.||||||.|.:|:||.:.:.|:.|..|.:
Frog   577 SFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGA 641

  Fly   611 IMTAGCDILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLSAQKKVKFG 675
            :|..|.:::|::...|:....||.|.:||.:|||||||||||..:||..|.:..||:.|.|:::|
Frog   642 LMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYG 706

  Fly   676 TIYGGSTYNLLADSNETVYRLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFLMETTTLEYHR 740
            .:..|||......|..:.|...:..|::...:|..|:|.||:.||...  ||..|||:|::||..
Frog   707 AVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVKNNDEGIQRVLTT--DYALLMESTSIEYVT 769

  Fly   741 EQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNPNASCFEEPD 805
            ::||:|..:|.....|.|.:..|.|:.||..:::|||:|.|.|:|:.:|:|||:  ...|.||..
Frog   770 QRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWR--GNGCPEEDS 832

  Fly   806 PDATPDMTFEELRGIFYTLYAGILIAFLIGITEFLVYVQQVA-LEERLTFKDAFKKEIRFVLCVW 869
            .:|:. :..|.:.|||..|.||::::..:.|.||:...::.: :|:.|:| :|..:|:...|
Frog   833 KEASA-LGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRKNSDIEQCLSF-NAIMEELGISL--- 892

  Fly   870 NNRKPIVAGTPISSVRTTPRRSLDKSLDRTPKSSRRVVIGRSS 912
              :.|                   |.|.:.||:.     ||||
Frog   893 --KHP-------------------KRLKKKPKAK-----GRSS 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	104/412 (25%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	18/96 (19%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	130/371 (35%)
		Lig_chan	554..828	CDD:278489	98/273 (36%)
grik1	XP_004912220.1	Periplasmic_Binding_Protein_Type_1	43..438	CDD:299141	108/425 (25%)
		ANF_receptor	61..404	CDD:279440	93/369 (25%)
		Periplasmic_Binding_Protein_Type_2	454..823	CDD:304360	131/376 (35%)
		Lig_chan	585..854	CDD:278489	98/273 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010