Protein Alignment GluRIIC and grik4

DIOPT Version :10

• Sequence 1: NP_608557.4
• Gene: GluRIIC / 33275
• FlyBaseID: FBgn0046113
• Length: 940
• Species: Drosophila melanogaster
• Sequence 2: XP_031761990.1
• Gene: grik4 / 100490768
• XenbaseID: XB-GENE-1011875
• Length: 962
• Species: Xenopus tropicalis
• Alignment Length: 976
• Identity: 274/976 - (28%)
• Similarity: 453/976 - (46%)
• Gaps: 125/976 - (12%)

  Fly     6 LLLGCMWSAFFMCRSRGQ-QINIGAFFYDDELELEK-EFMTVV---NAIN-GPESEQTMR----F 60
            ::|..:|    :.:|.|. .:.|.|.. ||.:|..: |.:::.   |.|| .||.:...|    .
 Frog     8 MVLVLLW----LMKSAGSPSLRIAAIL-DDPMECSRGERLSITLAKNRINRAPERQGKARLEVDI 67

  Fly    61 YPLIKRLKPEDGSVTMQEHACDLIDNGVAAIFGPS-SKAASDIVALVCNSTGIPHIEFDISDEGI 124
            :.|:|     |......|..|.::..||..:.||| |.::|.|::.:|....:|||:  :|.|..
 Frog    68 FELLK-----DSEYETAETMCQILPKGVLGVLGPSYSPSSSSIISNICGEKEVPHIK--VSTEEF 125

  Fly   125 QAEKPNHQMTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQLREVHNDVV 189
            ...:.....||||:|:...:|.|.|.:::.|  ...|.......|.....|:.||:...:..|.:
 Frog   126 LRFQYQRFTTLNLHPSNTDISAAVATLLRFF--NSTTACLICAKAECLLNLEKLLRQFLISKDCL 188

  Fly   190 RVRKFHKDDDFRVMWKSIRGER--RVVLDCEPNMLVELLNSSTEFGL-TGQYNHIFLTNLETYTD 251
            .||......|...:.|.||.::  .:::....:|...:|..:.|.|: |..|.:|| ||||....
 Frog   189 SVRMLDDTWDPTPLLKEIRDDKTSTIIVHANASMSHTILMKAAELGMVTAYYTYIF-TNLEFVLQ 252

  Fly   252 HLEELAADNETFAVNITAARLLVNPDPPPYSLPYGYVTQR------DNIVYESSDPPRTLIHDLI 310
            ..|....|.    |||....:.  .....|...:.:..|:      |:..:........|:.|.:
 Frog   253 RFESPLDDR----VNILGFSMF--NQSHSYFKEFAHTLQQSWEENCDHSPFTGPALSAALLFDAV 311

  Fly   311 HDALQLFAQSWRNASFFYPDRMVVPRITCDFAASGGRTWAMG----RYLARL-MKGTSGVNNTNF 370
            :..:....:..|:      ..:.|..::|    ...:.|..|    .||..: ::|.:|
 Frog   312 YGIVSAVQELNRS------QEIGVKPLSC----GSSQIWQHGTSLMNYLRMVELEGLTG------ 360

  Fly   371 RTSILQFDEDGQRITFNIEV--YDPLDGIGIAIWDPRGQITQ-LNVDVK-----AQKKMIYR--V 425
               .::|:..|||..:::::  |.......|..|    .:|. ||:|.:     |...::.:  :
 Frog   361 ---HVEFNSKGQRSNYDMKIMQYTKTGFQEIGQW----HVTNGLNMDKRYFSPNASDTLVNKTLI 418

  Fly   426 ATRI-----GPPYFSYNETARELNLTGNALYQGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDK 485
            .|.|     ..||.......:||.  ||..|:|:.||::..:|..:.|.|....|||..|| :.:
 Frog   419 VTTILFFLQENPYLMLKANHQELE--GNDRYEGFCVDMLKELAAILRFNYKIRLVADGVYG-VPE 480

  Fly   486 ETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKT--LDAYL 548
            ....|.|::||:|:..|.:.:..||||..|:..:||:.|||.||:||| |: .|:.:.  ..::|
 Frog   481 LNGTWTGMVGELISRKADLAVAGLTITAEREKVIDFSKPFMTLGISIL-YR-VHMGRKPGYFSFL 543

  Fly   549 APFGGEVWIWILISVFVMTFLKTIVARISKMDWENPHPCNRDP-EVLENQWRIHNTGWLTVASIM 612
            .||...||:::|::...::.:..:|||::..:|.:||||.:.. .:|.||:.:.|:.|..|...|
 Frog   544 DPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFM 608

  Fly   613 TAGCDILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLSAQKKVKFGTI 677
            ..|..|.||:...|.....||.|.:||.:|||||||||||..:|:..|.::.||:.|..:::|||
 Frog   609 QQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQTTIEYGTI 673

  Fly   678 YGGSTYNLLADSNETVYRLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFLMETTTLEYHREQ 742
            :|||:.....:|....|:..:|.|::..||.:.|...||:.||..:  :|.||:|:|..||:|::
 Frog   674 HGGSSMTFFQNSRYQTYQRMWNYMHSKQPSVFVKSTEEGIARVLNS--NYAFLLESTMNEYYRQR 736

  Fly   743 NCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNPNASCFEEPDPD 807
            ||:|..||.....|.|.|.:|.|:.:|....:|||:|.|...|.|||:|||  ....|.:|.|..
 Frog   737 NCNLTQVGGLLDTKGYGIGMPVGSAFRDEFDLAILQLQENNCLEDLKRKWW--DGGKCPKEEDHR 799

  Fly   808 ATPDMTFEELRGIFYTLYAGILIAFLIGITEFLVYV-----------QQVA--LEERLTFKDAFK 859
            | ..:..|.:.|||..|..|:::|.||.:.|||..|           |::|  |...:..||:|.
 Frog   800 A-KGLGMENIGGIFVVLICGLIVAILIAMLEFLWTVRNAEDSEVSVCQEMASELSSIILCKDSFL 863

  Fly   860 KEIRFVLCVWNNRKPIVAGTPISSVRTTPRRSLDKSLDRTPK----SSRRVVIGRSSEEMREMAQ 920
            ...|        |..::.|.||:.   ..||..:.|:....|    |....:..|.::|...:|:
 Frog   864 PRRR--------RGGVIRGRPITQ---DDRRGRNTSILSNGKLCGGSGPDPLTQRLAQEAALVAR 917

  Fly   921 G 921
            |
 Frog   918 G 918

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	Periplasmic_Binding_Protein_type1	26..409	CDD:471960	90/408 (22%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	137/380 (36%)
		Lig_chan	554..827	CDD:459656	101/273 (37%)
grik4	XP_031761990.1	Periplasmic_Binding_Protein_type1	23..400	CDD:471960	93/416 (22%)
		PBP2_iGluR_kainate_KA1	414..788	CDD:270442	138/382 (36%)