Protein Alignment GluRIIC and grid2

DIOPT Version :10

• Sequence 1: NP_608557.4
• Gene: GluRIIC / 33275
• FlyBaseID: FBgn0046113
• Length: 940
• Species: Drosophila melanogaster
• Sequence 2: XP_031759030.1
• Gene: grid2 / 100487676
• XenbaseID: XB-GENE-955038
• Length: 1007
• Species: Xenopus tropicalis
• Alignment Length: 962
• Identity: 249/962 - (25%)
• Similarity: 413/962 - (42%)
• Gaps: 171/962 - (17%)

  Fly    10 CMWSAFFMC---RSRGQQ-INIGAFFYDDELELEKEFMTVVNAINGPESEQTMRFYPLIKRLKPE 70
            || |.|:..   |:|... |:|||.|.:...:.::.|...|..:|  .:|..::...:...:...
 Frog     9 CM-SVFWTVSWGRTRADSIIHIGAIFDESAKKDDEVFRMAVADLN--LNEDILQTEKITFSVTFV 70

  Fly    71 DGSVTMQ--EHACDLIDNGVAAIFGPSSKAASDIVALVCNSTGIPHIEFDISDE-------GIQA 126
            ||:...|  :.||||:..|:.|:......|::..:..:.::..|||:....|..       |:|.
 Frog    71 DGNNPFQAVQEACDLMSQGILALVSSIGCASAGSLQSLADAMHIPHLFIQRSTARTPRSGCGLQR 135

  Fly   127 EKPNHQMTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDAD-DARAAARLQDLLQ-------LRE 183
            .......||::.| ...|:.....:|..:.|:||.:.||.: |.|......|.:.       |::
 Frog   136 SSGIDDYTLSVRP-PVYLNDVILRVVTEYAWQKFIVFYDNNYDIRGIQEFLDRVSQQGMDVALQK 199

  Fly   184 VHNDV----------VRVRKFHKDDDFRVMWKSIRGERRVVLDCEPNMLVELLNSSTEFGLTGQY 238
            |.|::          :|:.:.::..|..         ||.:|...|......:....|..|....
 Frog   200 VENNINRMITGLFATMRIEELNRYRDTL---------RRAILVMSPTTAKAFITEVVETNLVAFD 255

  Fly   239 NHIFLTNLETYTDHLEELAADNETFAVNITAARLLV--NPDPPPYSLPYGYVTQRDNIVYESSDP 301
            .|..:.|.|.....::||        |..:..||.:  ...|.|::...........|.....||
 Frog   256 CHWIIINEEINDLDVQEL--------VRRSIGRLTIIRQTFPVPHNSSQRCFRGNHRISTSLCDP 312

  Fly   302 PRTLIHDL------IHDALQLFAQSWRNASFFYPDRM--VVPRITCDFAASGGRTWAMGRYLARL 358
            ......::      |:|.:.|.|.::...   ..||.  .:..:||  .....:.|..||.:...
 Frog   313 KDPFSQNMEITNMYIYDTVLLLANAFHKK---LEDRKWHSMASLTC--IRKNSKPWQGGRSMLET 372

  Fly   359 MK--GTSGVNNTNFRTSILQFDEDGQRITFNIEV----YDPLDGIGI---AIWDPRGQITQLN-- 412
            :|  |.||:      |..|.|.|||.......|:    |....|.||   ..|:|   :|.||
 Frog   373 VKKGGVSGL------TGALDFSEDGGNPNIYFEILGTNYGEELGRGIRKLGFWNP---VTGLNGS 428

  Fly   413 -VDVKAQKKM---IYRVATRIGPPYFSYNETARELNLTGN-ALYQGYAVDLIDAIARHVGFEYVF 472
             .|.|.:..|   :.||||.:..|:...:|     |:.|. ..|||:::|::||::.::||:|..
 Frog   429 LTDRKLENNMRGVVLRVATVLEEPFVMVSE-----NVLGKPKKYQGFSIDVLDALSSYLGFKYEI 488

  Fly   473 VPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKS 537
            ...:|.:||. .:....|||:|||::...|.|||..||||..|:..||||..:|...|.:|..|:
 Frog   489 YVASDHKYGS-PQADGSWNGLIGELLLKRADMGISALTITPDRENVVDFTTRYMDYSVGVLLRKA 552

  Fly   538 PHVEKTLD--AYLAPFGGEVWIWILISVFVMTFLKTIVARISKMDWENPHPCNRDPEVLENQW-- 598
               |||:|  |.||||...:|..|..:|.::..|      :..::|.||      |.:.....
 Frog   553 ---EKTVDMFACLAPFDLSLWACIAGTVLLVGLL------VYLLNWLNP------PRLQMGSMTS 602

  Fly   599 -RIHNTGWLTVASIMTAGCDILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIAN 662
             .::|:.|....|.:..|.::...:...||....||:||:|:.:|||||||||||.|::|.||.:
 Frog   603 TTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTISRIESSIQS 667

  Fly   663 LKDLSAQKKVKFGTIYGGSTY------NLLADSNETVYRLAFNLMNNDDPSA-YTKDNLEGVDRV 720
            |:|||.|..:.:||::..:.|      .:.....:::|...:.::|..:.|. ..:::|||:.:|
 Frog   668 LQDLSRQTDIPYGTVFDSAVYEHVRVKGMNPFERDSMYSQMWRMINRSNGSENNVQESLEGIQKV 732

  Fly   721 RKNRGDYMFLMETTTLEY--HREQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERG 783
            :  .|:|.|:.:...|||  ..:|:|...:||....::.|.||:..|:.||...|..||:|.:.|
 Frog   733 K--HGNYAFVWDAAVLEYIAINDQDCSFYTVGNTIADRGYGIALQHGSPYRDIFSQRILELQQNG 795

  Fly   784 ELYDLKQKWWKNPNASCFEEPDPDAT---PDMTFEELRGIFYTLYAGILIAFLIGITEFLVYVQQ 845
            ::..||.|||.. |..|......|..   ..:..:...|:|..|.|||:::..|.:.|
 Frog   796 DMDILKHKWWPR-NGQCELHSSMDTKQKGSSLDIKSFSGVFCILAAGIVLSCFIAMVE------- 852

  Fly   846 VALEERLTFKDAFKKEIRFVLCVWNNRKPIVAGTPISSVRTTPRRSLDKSLD 897
                   |:              ||.:|    |:.:      |.:..||.:|
 Frog   853 -------TW--------------WNKKK----GSRV------PSKEDDKEID 873

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	Periplasmic_Binding_Protein_type1	26..409	CDD:471960	89/428 (21%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	126/385 (33%)
		Lig_chan	554..827	CDD:459656	81/287 (28%)
grid2	XP_031759030.1	Periplasmic_Binding_Protein_type1	28..429	CDD:471960	92/434 (21%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	126/388 (32%)