Protein Alignment GluRIIC and grin2cb

DIOPT Version :9

• Sequence 1: NP_608557.4
• Gene: GluRIIC / 33275
• FlyBaseID: FBgn0046113
• Length: 940
• Species: Drosophila melanogaster
• Sequence 2: XP_009305071.2
• Gene: grin2cb / 100333648
• ZFINID: ZDB-GENE-100308-2
• Length: 1328
• Species: Danio rerio
• Alignment Length: 1043
• Identity: 215/1043 - (20%)
• Similarity: 386/1043 - (37%)
• Gaps: 260/1043 - (24%)

  Fly     9 GCMWSA----FFM---------CRSR----GQQINIGAFFYDD----------------ELELEK 40
            ||:..:    ||.         ||.|    ...:|:...|...                ::.||.
Zfish     6 GCLGPSLQLLFFFHLLLNVVPRCRGRPFFGPPSVNVAVVFSGSAHHSEIKGRLSPENFLDMPLEV 70

  Fly    41 EFMTVVNAINGPESEQTMRFYPLIKRLKPEDGSVTMQEHACDLIDNGVAAIFGPSSKAASDIVAL 105
            ..:||:.....|.:        |:.||        .|..|.:.: :||.......|:|.:.|:..
Zfish    71 NPITVLVNDTNPRA--------LLTRL--------CQTMAAESL-HGVVFEDDVDSEAVAQILDF 118

  Fly   106 VCNSTGIPHIEFDISDEGIQAEKPNHQMTLNLYPAQAILSKAYADIVQNFGWRKFTIV------Y 164
            |.:.|.||.:........:...|.:....|.:..:......|...:::.:.|..|.::      |
Zfish   119 VSSQTSIPIVGISGGSAVVIPHKADGSTFLQMGASIDQQINAMFKVMEEYNWGNFVVITSLYPGY 183

  Fly   165 D---------ADDARAAARLQDLLQLR-EVHNDVVRVRKFHKDDDFRVMWKSIRGERRVVLDCEP 219
            :         .|.:.....|||:|... .|..:.:|.|:..:..|.:|          .::.|..
Zfish   184 ETFVDYIRSFTDTSYFLWELQDVLSFEMSVGANDIRTRRLLQQVDSQV----------YLVYCSH 238

  Fly   220 NMLVELLNSSTEFGLTGQYNHIFLTNLETYTDHLEELAADNETFAVNITAARLLVNPDPPPYSLP 284
            .....|...:::.||.|. .:|::         :..||..|...|              ||.|.|
Zfish   239 EEAQYLFRMASDVGLLGP-GYIWI---------VPSLAVGNPEAA--------------PPASFP 279

  Fly   285 YGYVTQRDNIVYESSDPPRTLIHDLIHDALQLFAQSWRNASFFYPDRMVVPRITCDFAASGGRTW 349
            .|.:    :|:   :|..|..:...:.:.:.:..   :....|:..|..:|....| .:|..:::
Zfish   280 VGVI----SII---TDRWRKTLRQRVREGVAIIV---KGVHSFHKHRGFIPEGHSD-CSSPVKSY 333

  Fly   350 AMGRYLARLMKGTSGVNNTNFRTSILQFDEDGQRITFNIEVY--DPLDGIGIAI-----WDP--- 404
            |               ||:.|| .:|....:.:.::||.:.|  :| ..:.||:     ||.
Zfish   334 A---------------NNSLFR-HMLNVSWEHKDLSFNSDGYLTNP-SMVIIALDRENHWDKVGS 381

  Fly   405 -RGQITQLNVDV---------KAQKKMIYRVATRIGPPYFSYNET--------------ARELNL 445
             .|.|.|:...|         .........|||....|:......              .|:.|.
Zfish   382 YEGGILQMRYPVWPRYGSFLEPVSDNRHLTVATLEERPFVIVESVDPATGTCVRNTVPCRRQSNR 446

  Fly   446 TGNAL----------YQGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINN 500
            |.:.:          .:|:.:|::..::|.:.|.|....|.:.::||:.:..  |||:|||:...
Zfish   447 TESIIGHTEPYTKLCCKGFCIDILKKLSRTIKFSYDLYLVTNGKHGKMVRGV--WNGMIGEVFYK 509

  Fly   501 DAHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKTLDAYLAPFGGEVWIWILISVFV 565
            .|.|.|..|||.:.|...|||:|||::.|:|::..:| :...:..|:|.|:...||    :.:||
Zfish   510 RADMAIGSLTINEERSEIVDFSVPFVETGISVMVARS-NGTVSPSAFLEPYSPAVW----VMMFV 569

  Fly   566 MTFLKTIVARISKMDWENPHPCNRD---------PEVLENQWRIHNTGWLTVASIMTAGCDI-LP 620
            |. |..:...:...::.:|...||.         |     .:.|..:.||....:......| .|
Zfish   570 MC-LTVVAVTVFVFEYFSPVGYNRSLVSAKAPGGP-----TFTIGKSVWLLWGIVFNNSVPIENP 628

  Fly   621 RSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLSAQK------KVKFGTIYG 679
            :....::....|..||:|...|||||||||:...:...:::.|.|...||      ..:|||:..
Zfish   629 KGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQKPQEHYPPFRFGTVPN 693

  Fly   680 GSTYNLLADSNETVYRLAFNLMNNDDPSAYT---KDNLEGVDR----VRKNRGDYMFLMETTTLE 737
            |||..              |:.:| .|..:|   |.|.:||:.    ::..:.| .|:.:...|.
Zfish   694 GSTER--------------NIRSN-YPDMHTHMIKYNQKGVEEALNSLKTGKLD-AFIYDAAVLN 742

  Fly   738 Y--HREQNCDLRSV--GEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNPNA 798
            |  .:::.|.|.::  |:.|....|.||:...:.::..:.:|:|:....|:...|:..|.   :.
Zfish   743 YMAGKDEGCKLVTIGSGKVFATTGYGIALQKDSRWKRPIDLALLQFLGDGDTQRLETVWL---SG 804

  Fly   799 SCFEEPDPDATPDMTFEELRGIFYTLYAGILIAFLIGITEFLVYVQ---QVALEERLTFKDAFKK 860
            .|..|.:...:..:..:.:.|:||.|...:.::.|:...|.|:|.:   .|...:||.|..|..
Zfish   805 ICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLLYWKLRHSVHKSDRLDFLLAIS- 868

  Fly   861 EIRFVLCVWNNRKPIVAGTPISSVRTTPR-------------------RSLDKSLDRTPKS---- 902
              |.:...:|..:.|...|.|.:...|..                   ..::.|||...|:
Zfish   869 --RGIYSCFNGVEDIGRSTGIQNPDITANYAQANMLKMLQTAKDIVSSAKVENSLDNATKTIENW 931

  Fly   903 SRR 905
            |||
Zfish   932 SRR 934

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	73/416 (18%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	14/83 (17%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	102/421 (24%)
		Lig_chan	554..828	CDD:278489	68/300 (23%)
grin2cb	XP_009305071.2	PBP1_iGluR_NMDA_NR2	37..396	CDD:107373	78/437 (18%)
		PBP2_iGluR_NMDA_Nr2	407..808	CDD:270436	103/432 (24%)
		NMDAR2_C	845..>932	CDD:313729	17/89 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591068
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840