Protein Alignment GluRIIC and grin3bb

DIOPT Version :10

• Sequence 1: NP_608557.4
• Gene: GluRIIC / 33275
• FlyBaseID: FBgn0046113
• Length: 940
• Species: Drosophila melanogaster
• Sequence 2: XP_017213803.2
• Gene: grin3bb / 100333101
• ZFINID: ZDB-GENE-131122-77
• Length: 1114
• Species: Danio rerio
• Alignment Length: 1032
• Identity: 208/1032 - (20%)
• Similarity: 363/1032 - (35%)
• Gaps: 288/1032 - (27%)

  Fly    82 DLIDNGVAAIFG-PSSKAASDIVALVCNST--GIPHIEFDISDEGIQAEKPNH-QMTLNLYPAQA 142
            |::..||:|:.. |.::  .:||.:...|:  .||.|......|.::.:...| |||..:.|:.
Zfish   108 DIVVQGVSAVLAFPQTQ--EEIVQMEFMSSFLEIPFISIIEHGEPLKTQNRFHLQMTTRIPPSG- 169

  Fly   143 ILSKAYADIVQNFGWRKFTIV--YDADDARAAARLQDLLQLREVHNDVVRVRKFHKDDDFRVMWK 205
             |.:....::|..||.:...|  :..:|    |.|.|||:|:.                 |..|.
Zfish   170 -LVELLLAVLQRSGWEESMAVLCHGWED----AGLLDLLKLQG-----------------RFGWG 212

  Fly   206 SIRGERRVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNLETYTDHLEE--------------L 256
            ..:...|..|:         |:.||             ..:...:|.|.|              .
Zfish   213 PSQWHLRAALN---------LSHST-------------ARMANISDFLSEHFNLDHSPPASVLLF 255

  Fly   257 AADNETFAVNITAARLL--------------VNPDP------PPYSLPYGYVTQRDNIVYESSDP 301
            .||.|..:..:.:|..|              ::||.      |...|.||.|..:....|
Zfish   256 GADPECASSVLRSAHDLGLTLPTVHWIMGHPLSPDALHSIGLPLGLLAYGEVDHKPLDFY----- 315

  Fly   302 PRTLIHDLIHDALQLFAQSWRNASFFYPDRMVVPR-ITCDFAASGGRTWAMGRYLARLMKGTSGV 365
                    |.|||||..::...|:...||..::.. :.|....:.....:.|:|:||.:..||.|
Zfish   316 --------ISDALQLINRAVTAATVVRPDLALIQNMVNCFDKPNKHELPSSGQYIARFLSNTSFV 372

  Fly   366 NNTNFRTSILQFDEDGQRITFNIEVYD-PLDGIGIAIWDPRG--QITQLNVD-----------VK 416
            ..|.  ..|:|.:......:..:.::. ..|.:|...|...|  :..:|||:           .:
Zfish   373 GLTG--PVIVQRNLSRVHTSHKVHIWSLRRDAVGQPTWVTVGSWEGGRLNVEEQGLWQGSSPRQR 435

  Fly   417 AQKKM----------------IYRVATRIGPPYFSYNETARELNLTGNA---------------- 449
            .:.:|                ..||.|.:..|:.    ..||::..||.
Zfish   436 TEGQMGREGRRWRAGFPVSGSRLRVVTLVEHPFV----FTREVDEDGNCPAGQYCLDAGTNSSET 496

  Fly   450 ---LY-------------------QGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQWNG 492
               ||                   .||.:||::.::..:.||:....|.|.:||.:  :..||.|
Zfish   497 LDHLYAERAQGNKSFLPPDYSKCCYGYCIDLLEKLSEDMNFEFDLYIVGDGKYGAV--KGGQWTG 559

  Fly   493 IIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKTLDAYLAPFGGEVWI 557
            ::|::::..|.|.:...:|..||...:|||.||....:.||. :|......:.|::.|....:|:
Zfish   560 LVGDLLSGVADMAVTSFSINSARSKVIDFTSPFFSTSLGILV-RSKDTAAPIGAFMWPLHWSMWM 623

  Fly   558 WILISVFVMTFLKTIVARISKMDWENPH---PCNRDPEVLENQWRIHN-TGWLTVASIMTAGCDI 618
            .|.:::.:.....|:      .:|::|.   |..|      |:.::.: :..|.:...:..|..:
Zfish   624 GIFVALHITALFLTL------YEWKSPFGMTPHGR------NRVKVFSYSSALNLCYAILFGRTV 676

  Fly   619 LPRSPQV---RMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLS---AQKKVKFGTI 677
            ..::|:.   |.....|.||.:::.:||||||||.:...|....::.:.|..   ..:..:|||:
Zfish   677 SSKTPKCWTGRFLMNLWAIFCLLVLSSYTANLAAVMVGEKTFEEVSGIHDAKLHHPSQGFRFGTV 741

  Fly   678 YGGSTYNLLADSNETV--YRLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFLMETTTLEYH- 739
            ...|..:.:..|...:  |...||.....|..|..|.:...:|         .|:|:...|:|.
Zfish   742 RESSAEDYMKKSFPEMHEYMRKFNEPTTPDGVATLKTDPPQLD---------AFIMDKALLDYEV 797

  Fly   740 -REQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWK----NPNAS 799
             .:.:|.|.:||:.|..:.|.|.:|..:...||:|..:.:....|.:..|..||:|    .....
Zfish   798 SIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNISEFVSRYKSDGYMDMLHDKWYKVVPCGKRVF 862

  Fly   800 CFEEPDPDATPDMTFEELRGIFYTLYAGILIAFLIGITEFLVY-------------------VQQ 845
            ...|     |..|......|:|..|..|:..|.|....|...|                   .|:
Zfish   863 AVTE-----TLQMGIRHFSGLFVLLCVGVTGALLTLAGEHAFYRLVLPHIRRKQKFKYWLHTSQK 922

  Fly   846 VALEERLTFKDAFKKEIRF---------------------VLCVWNNRKPIVAGTPISSVRTTPR 889
            :.....:|::|..::....                     ....|||....||
Zfish   923 IHRALNMTYEDVKRQRANTEKSCNIQKAQPHPPPQPAPLGSFARWNNESAKVA------------ 975

  Fly   890 RSLDKSLDRTPKSSRRVVIGRSSEEMREMAQ------GSGSSSGSNNAGRGEKEARV 940
                    :.||.::||.....:...|.:..      |..||:.:.::|.|...|||
Zfish   976 --------QEPKDNKRVHFNLETLNTRRLLPRVVSDGGQTSSASTLSSGAGSLLARV 1024

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	Periplasmic_Binding_Protein_type1	26..409	CDD:471960	76/370 (21%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	95/422 (23%)
		Lig_chan	554..827	CDD:459656	63/290 (22%)
grin3bb	XP_017213803.2	Periplasmic_Binding_Protein_type1	39..427	CDD:471960	79/380 (21%)
		PBP2_iGluR_NMDA_Nr3	457..852	CDD:270438	94/422 (22%)
		Lig_chan	618..885	CDD:459656	63/292 (22%)