Protein Alignment GluRIIC and grin2db

DIOPT Version :10

• Sequence 1: NP_608557.4
• Gene: GluRIIC / 33275
• FlyBaseID: FBgn0046113
• Length: 940
• Species: Drosophila melanogaster
• Sequence 2: XP_073782035.1
• Gene: grin2db / 100149482
• ZFINID: ZDB-GENE-100920-7
• Length: 1984
• Species: Danio rerio
• Alignment Length: 998
• Identity: 194/998 - (19%)
• Similarity: 357/998 - (35%)
• Gaps: 291/998 - (29%)

  Fly    67 LKPEDGSV-TMQEHACDLIDNGVAAIFGPSSKAASDIVALVCN-------STG--IPHIEFDISD 121
            |:..|.|. |:....|||:             ||..:..||..       :||  .|.:||..:.
Zfish   121 LQVNDSSPRTLLSQLCDLL-------------AARPLQGLVYEDERPLPLATGPLAPMLEFVSAQ 172

  Fly   122 EGI------------QAEKPNHQMTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAAR 174
            .|:            :..:.:..:.|....:.|:..:...::::.:.|..|::|......
Zfish   173 TGLPIVAVGGGAALGRVPQESGSIFLQFSSSTALQLEVIFEVLEEYDWTAFSVVSTRHHG----- 232

  Fly   175 LQDLLQLREVHND---------------------VVRVRKFHKDDDFRVMWKSIRGERRVVLDCE 218
            .||.|.:.|...|                     .||.::..|:::.:|.          :|.|.
Zfish   233 YQDFLSVVEGLTDGSFIGWEKKSIVMLNLTDDPGGVRTQRLLKENEAQVR----------LLYCS 287

  Fly   219 PNMLVELLNSSTEFGLTGQYNHIFLTNLETYTDHLEELAADNETFAVNITAARLLVNPDPPPYSL 283
            .....::..::...|..|. :||:                    |||....:.|.:...|.
Zfish   288 QEEAEQVFLAAWAAGQAGA-SHIW--------------------FAVGPALSELGLTGLPK---- 327

  Fly   284 PYGYVTQRDNIVYESSDPPRTLIHDLIHDALQLFA---QSWRNASFFYPDRMVVPRITC------ 339
                                           :|||   |.||:.    |.|.:...::.
Zfish   328 -------------------------------RLFAVRPQGWRDE----PRRRIARGVSILTHGAV 357

  Fly   340 ----DFAASGG---------------RTWAMGRYLARLMKGTSGVNNTNFRTSILQFDEDGQRIT 385
                |:.|:||               |.....||.:.:..|....:          |..:|....
Zfish   358 ALRKDYGATGGPHFVTNCQTDGNRTQRIRGRMRYFSNITLGGRDYS----------FSNEGYLAN 412

  Fly   386 FNIEV--YDPLDGIGIAIWDPRGQITQLNVDVKAQKKMIYRVATRIGPPYFSYNETARELN---- 444
            ..::|  |.|..|.....|...|.:           ::.|...:|.| |:....:.|:.|.
Zfish   413 PFLDVISYTPGSGWEDVGWWENGVL-----------RLRYPAWSRYG-PFLQPPDDAQHLRVVTL 465

  Fly   445 ----------------------------LTGNALYQ----------GYAVDLIDAIARHVGFEYV 471
                                        |..:||.:          |:.:|::..:||.|||.|.
Zfish   466 EERPFVIVELADAASGTCIRDSVPCRRPLNASALQEGVAPVKQCCKGFCIDILKRLARIVGFTYD 530

  Fly   472 FVPVADQQYGKLDKETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILAYK 536
            ...|.:.::||  |....|||::||::...|.|.|..|||.:.|...|||:|||::.|:|::..:
Zfish   531 LYLVTNGKHGK--KIDGVWNGMVGEVVYKRADMAIGSLTINEERSEVVDFSVPFVETGISVMVSR 593

  Fly   537 SPHVEKTLDAYLAPFGGEVWIWILISVFVMTFLKTIVARISKMDWENPHPCNRD----PEVLENQ 597
            | :...:..|:|.|:...||    :.:|||. |..:...:...::.:|...||.    .:...::
Zfish   594 S-NGTVSPSAFLEPYSPAVW----VMMFVMC-LTVVAVTVFIFEFFSPVGYNRSLQSGKKAGGSK 652

  Fly   598 WRIHNTGWLTVASIMTAGCDI-LPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIA 661
            :.|..:.||..|.:......: .|:....::....|..||:|...|||||||||:...:...:::
Zfish   653 FTIGKSIWLLWALVFNNSVPVENPKGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYIDTVS 717

  Fly   662 NLKDLSAQ------KKVKFGTIYGGSTYNLLADSNETV--YRLAFNLMNNDDPSAYTKDNLEGVD 718
            .|.|...|      ..:||||:..|||...:..:...:  |.:.:|..:.:|          .:.
Zfish   718 GLSDKKFQHPTEQYPPLKFGTVPNGSTEKNIRSNYPDMHQYMVKYNQKSVED----------AIS 772

  Fly   719 RVRKNRGDYMFLMETTTLEY--HREQNCDLRSV--GEKFGEKHYAIAVPFGAEYRSNLSVAILKL 779
            .::..:.| .|:.:...|.|  .:::.|.:.::  |:.|....|.||:...:.::..|.:|:|:|
Zfish   773 HLKTGKLD-AFIYDAAVLNYMARKDEGCKVMTIGSGKVFATTGYGIALIKNSRWKRPLDLALLQL 836

  Fly   780 SERGELYDLKQKWWKNPNASCFEEPDPDATPDMTFEELRGIFYTLYAGILIAFLIGITEFLVY-- 842
            ....|:..|::.|.   :..|..:.....:..:..:.:.|:||.|...:.::.|:...|.|||
Zfish   837 VGDDEIEMLERLWL---SGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWR 898

  Fly   843 ----VQQVALEERLTFKDAFKKEIRFVLCVWNNR------KPIVAGTPISSVRTTPRRSLDKSLD 897
                :.::....:|.|..||.:.: :..|.:.:.      |..|:|...:::
Zfish   899 LRHCMSKMGQSGKLDFLLAFSRGM-YSCCSFEDETAQGGAKVTVSGHHHTAM------------- 949

  Fly   898 RTPKSSRRVVIGRSSEEMREMAQ 920
             .|.||..||....|.....|.|
Zfish   950 -VPTSSSHVVTSAVSNPAIAMVQ 971

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	Periplasmic_Binding_Protein_type1	26..409	CDD:471960	66/414 (16%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	102/429 (24%)
		Lig_chan	554..827	CDD:459656	62/289 (21%)
grin2db	XP_073782035.1	None