DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIC and gria3

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	NP_001106494.1	Gene:	gria3 / 100127683	XenbaseID:	XB-GENE-1010483	Length:	887	Species:	Xenopus tropicalis

Alignment Length:	895	Identity:	265/895 - (29%)
Similarity:	414/895 - (46%)	Gaps:	85/895 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ILLLGCMWSAFFMCRSRGQQINIGAFFYDDELELEKEFMTVVNAINGPESEQTMRFYPLIKRLKP 69
            :|||..:..:   |......||||..|..:.::....|:..|. ::......|.|.:.|...:..
Frog    11 LLLLSLVGES---CGGFPNTINIGGLFMRNTIQEHSAFLFAVQ-LHNTNQNNTERPFQLFHHVDH 71

  Fly    70 ED--GSVTMQEHACDLIDNGVAAIFGPSSKAASDIVALVCNSTGIPHIEFDISDEGIQAEKPNHQ 132
            .|  .|.::....|.....||.||||...:.:.:.:...|   |..|..|........|:.   |
Frog    72 LDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFC---GALHTSFITPSFPTDADV---Q 130

  Fly   133 MTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQLREVHNDVVRVRKFHKD 197
            ..:.:.|.   |..|...::..:.|:||..:||.:  |..:.||.:::....:|..|..|.....
Frog   131 FVIQMRPP---LKGAILTLLNEYDWQKFVYLYDTE--RGFSILQAIMEAAVQNNWQVTARSVGNI 190

  Fly   198 DDFRVMWKSI-----RGERRVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNLETYTDHLEELA 257
            .|.:...:.|     |.|:|.|:|||...:..:|......|...:..|..|.||......||.:.
Frog   191 KDVQEFKRIIEEMDRRQEKRFVIDCEVERINTILEQVVILGKHTRGYHYMLANLGFTGFTLERVM 255

  Fly   258 ADNETFAVNITAARLLVNPDPPPYSLPYGYVTQRDNIVYESSDPPRTLIHDLIHDALQLFAQSWR 322
            ..    ..|:|..:::.|.:|........:|...:....|:.:.|......|.|||:.:.|:::|
Frog   256 HG----GANVTGFQIVNNENPIVQQFLQRWVRLDEREFPEARNTPLKYTSALTHDAVLVIAEAFR 316

  Fly   323 NASFFYPDRMVVPR--ITCDFAASGGRTWAMGRYLARLMKGTSGVNNTNFRTSILQFDEDGQRIT 385
               :....|:.|.|  ...|..|:....|:.|..:.|.:|    :......|..:|||..|:|..
Frog   317 ---YLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALK----MVQVQGMTGNIQFDTYGRRTN 374

  Fly   386 FNIEVYD-----PLDGIGIAIWD--------PRGQITQLNVDVKAQKKMIYRVATRIGPPYFSYN 437
            :.|:||:     |..   :..|:        |..|.|  |.....:.|.|. |.|.:..||....
Frog   375 YTIDVYEMTATKPRK---VGHWNEYERFVPAPDQQPT--NESSSVENKTII-VTTILENPYVMKK 433

  Fly   438 ETARELNLTGNALYQGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINNDA 502
            :. .|| |.||..|:||.|||...||:|||.:|....|.|.:||..|.|||.|||::||::...|
Frog   434 KN-HEL-LDGNDKYEGYCVDLASEIAKHVGIKYKLSIVEDGKYGARDPETKIWNGMVGELVYGRA 496

  Fly   503 HMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKTLDAYLAPFGGEVWIWIL---ISVF 564
            .:.:..||||..|:..:||:.|||.||:||:..|....:..:.::|.|...|:|:.|:   |.|.
Frog   497 DIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVS 561

  Fly   565 VMTFLKTIVARISKMDW-----------ENPHPCNRDPEVLENQWRIHNTGWLTVASIMTAGCDI 618
            |:.||   |:|.|..:|           :||    .||   .|::.|.|:.|.::.:.|..||||
Frog   562 VVLFL---VSRFSPYEWHLEDTDEARDPQNP----PDP---PNEFGIFNSLWFSLGAFMQQGCDI 616

  Fly   619 LPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLSAQKKVKFGTIYGGSTY 683
            .|||...|:....||.|.:||.:|||||||||||..:|...|.:.:||:.|.::.:||:..|||.
Frog   617 SPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTK 681

  Fly   684 NLLADSNETVYRLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFLMETTTLEY-HREQNCDLR 747
            .....|...||...::.|.:.:||.:||...:||.||||::|.:.||:|:|..|| .:.:.||..
Frog   682 EFFRRSKIAVYEKMWSYMKSAEPSVFTKTTDDGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTM 746

  Fly   748 SVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNP-NASCFEEPDPDATPD 811
            .||.....|.|.:|.|.|:...:.:::|:|||||:|.|..||.|||.:. .....:....|.|..
Frog   747 KVGGNLDSKGYGVATPKGSALGTPVNLAVLKLSEQGILDKLKNKWWYDKGECGAKDSGSKDKTSA 811

  Fly   812 MTFEELRGIFYTLYAGILIAFLIGITEFLVYVQQVALEERLTFKDA--FK 859
            ::...:.|:||.|..|:.:|.::.:.||....:..:...:|| |:|  ||
Frog   812 LSLSNVAGVFYILVGGLGLAMMVALIEFCYKSRAESKRMKLT-KNAQNFK 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	88/399 (22%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	18/85 (21%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	149/385 (39%)
		Lig_chan	554..828	CDD:278489	104/289 (36%)
gria3	NP_001106494.1	Periplasmic_Binding_Protein_Type_1	29..400	CDD:324556	88/396 (22%)
gria3	NP_001106494.1	PBP2_iGluR_AMPA	416..798	CDD:270433	152/394 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.100