DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIC and gria1

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	XP_004912781.1	Gene:	gria1 / 100127569	XenbaseID:	XB-GENE-995621	Length:	903	Species:	Xenopus tropicalis

Alignment Length:	875	Identity:	256/875 - (29%)
Similarity:	404/875 - (46%)	Gaps:	130/875 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 INIGAFFYDDELELEKEFMTVVNAINGPESEQTMRFYPLIKRLKPEDGSVTMQEHACDLIDNGVA 89
            |.||..|.:.:.:....|...::.::.|.     :..|.|..:...| |..|....|.....||.
Frog    25 IQIGGLFPNQQSQEHAAFRFALSQLSEPP-----KLLPQIDIVNISD-SFEMTYTFCSQFSKGVY 83

  Fly    90 AIFGPSSKAASDIVALVCNSTGIPHIEFDISDEGIQAEKP---NHQMTLNLYPAQAILSKAYADI 151
            ||||...:...:::...|   |..|:.|      |....|   ::|..|.|.|.   |..|...:
Frog    84 AIFGFYDRKTVNMLTSFC---GALHVCF------ITPSFPVATSNQFVLQLRPE---LQDALISV 136

  Fly   152 VQNFGWRKFTIVYDADDARAAARLQDLLQLREVHN-DVVRVRKF-HKDDDFRVMWKSI--RGERR 212
            ::.:.|:||..:||||  |..:.||.:|......| .|..|... ..::.:|::::.:  ..:|:
Frog   137 IEYYKWKKFVYIYDAD--RGLSVLQKVLDTAAEKNWQVTAVNILTTTEEGYRLLFQDLDKSKDRQ 199

  Fly   213 VVLDCEPNMLVELLNS---STEFGLTGQYNHIFLTNLETYTDHLEELAADNETF---AVNITAAR 271
            :|:|||...|..:|..   ..|..:.|.  |..|.|| .:.|      .|.:.|   ..|:|..:
Frog   200 IVIDCESERLNAILTQVVVKLEKNIIGY--HYILANL-GFMD------IDMQKFKEAGANVTGFQ 255

  Fly   272 LLVNPDPPPYSLPYGYVTQRDNIV---------YESSDPPRT------LIHDLIHDALQLFAQSW 321
            |               |...|.:|         |:..:.||.      ....|.:|.:::.|:::
Frog   256 L---------------VNYTDTMVSRIMQQWKNYDGREQPRVDWKKPKYTSALTYDGVRVMAEAF 305

  Fly   322 RNASFFYPDRMVVPR--ITCDFAASGGRTWAMGRYLARL-----MKGTSGVNNTNFRTSILQFDE 379
            ::   ....|:.:.|  ...|..|:....|..|..:.|.     ::|.||         .:||:|
Frog   306 QS---LRKQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRLEGLSG---------NVQFNE 358

  Fly   380 DGQRITFNIEVYD-PLDGI-GIAIWDPRGQITQLNVDVKAQKKMI------YRVATRIGPPYFSY 436
            .|:|..:.:.|.: ..:|| .||.|:...::..|..|.:|....|      |.|.|.:..||...
Frog   359 KGRRTNYTLHVLELKHEGIRHIAHWNEDDKLIPLATDAQAGNDTIGVQNRTYIVTTILEAPYVML 423

  Fly   437 NETARELNLTGNALYQGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDKETKQWNGIIGEIINND 501
            .:.|.:|.  ||..::||.|:|...||:||||:|....|.|.:||..|.:.|.|||::||::...
Frog   424 KKNADQLE--GNDRFEGYCVELAAEIAKHVGFKYKLEIVKDGKYGARDSDMKAWNGMVGELVYGR 486

  Fly   502 AHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKTLDAYLAPFGGEVWIWIL---ISV 563
            |.:.:..||||..|:..:||:.|||.||:||:..|....:..:.::|.|...|:|:.|:   |.|
Frog   487 ADLAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGV 551

  Fly   564 FVMTFLKTIVARISKMDWENPHPCNRDPEVLE-----------NQWRIHNTGWLTVASIMTAGCD 617
            .|:.||   |:|.|..:|.|        |..|           |::.|.|:.|.::.:.|..|||
Frog   552 SVVLFL---VSRFSPYEWHN--------EEFEEGKEQPTTDQSNEFGIFNSLWFSLGAFMQQGCD 605

  Fly   618 ILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLSAQKKVKFGTIYGGST 682
            |.|||...|:....||.|.:||.:|||||||||||..:|...|.:..||:.|.::.:||:..|||
Frog   606 ISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESADDLAKQTEIAYGTLDSGST 670

  Fly   683 YNLLADSNETVYRLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFLMETTTLEY-HREQNCDL 746
            ......|...|:...:..|.:.:||.:.|...||::||||::|.|.:|:|:|..|| .:.:.||.
Frog   671 KEFFKRSKIAVFEKMWTYMRSAEPSVFVKTTEEGMNRVRKSKGKYAYLLESTMNEYIEQRKPCDT 735

  Fly   747 RSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNPNASC--FEEPDPDAT 809
            ..||.....|.|.||.|.|:..|..:::|:|||||:|.|..||.|||.: ...|  .:....|.|
Frog   736 MKVGGNLDSKGYGIATPKGSPLRGAVNLAVLKLSEQGVLDKLKSKWWYD-KGECGSKDSGSKDKT 799

  Fly   810 PDMTFEELRGIFYTLYAGILIAFLIGITEF 839
            ..::...:.|:||.|..|:.:|.|:.:.||
Frog   800 SALSLSNVAGVFYILIGGLGLAMLVALIEF 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	93/414 (22%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	17/105 (16%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	145/385 (38%)
		Lig_chan	554..828	CDD:278489	104/290 (36%)
gria1	XP_004912781.1	PBP1_iGluR_AMPA_GluR1	26..393	CDD:380613	93/422 (22%)
gria1	XP_004912781.1	PBP2_iGluR_AMPA_GluR1	407..788	CDD:270447	146/394 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000