DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIC and gria4

DIOPT Version :9

Sequence 1:	NP_608557.4	Gene:	GluRIIC / 33275	FlyBaseID:	FBgn0046113	Length:	940	Species:	Drosophila melanogaster
Sequence 2:	XP_031751480.1	Gene:	gria4 / 100125052	XenbaseID:	XB-GENE-5838893	Length:	902	Species:	Xenopus tropicalis

Alignment Length:	911	Identity:	264/911 - (28%)
Similarity:	418/911 - (45%)	Gaps:	107/911 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 QRILLLGCMW----SAFFMCRSRGQQINIGAFFYDDELELEKEFMTVVNAI----NGP-ESEQTM 58
            |.:|.....|    .||      ...:.||..|..:   .::|:.....||    ..| |||...
Frog     7 QMVLFFSGFWGLAMGAF------PSSVQIGGLFIRN---TDQEYTAFRLAIFLHNTSPNESEALF 62

  Fly    59 RFYPLIKRLKPEDGSVTMQEHACDLIDNGVAAIFGPSSKAASDIVALVCNSTGIPHIEFDISDEG 123
            ...|.:..::..: |..:....|.....||.||||...|.:...:...|::..|..|......||
Frog    63 NLVPHVDNIETSN-SFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITPSFPTEG 126

  Fly   124 IQAEKPNHQMTLNLYPAQAILSKAYADIVQNFGWRKFTIVYDADDARAAARLQDLLQLREVHN-- 186
                  ..|..|.|.|:   |..|...::.::||..:..:||.|  |..:.||.:::....:.
Frog   127 ------ESQFVLQLRPS---LRGALLSLLDHYGWNHYVFLYDTD--RGYSILQAIMEKAGQNGWQ 180

  Fly   187 -DVVRVRKFHKDDDFRVMWKSI--RGERRVVLDCEPNMLVELLNSSTEFGLTGQYNHIFLTNLET 248
             ..:.|..|: |..:|.:.:.:  |.|.:.|:|||...|..:|......|...:..|..:.||
Frog   181 VSAICVENFN-DASYRRLLEDLDRRQENKFVIDCEVERLQNILEQIVSVGKHVKGYHYIIANL-- 242

  Fly   249 YTDHLEELAADNETF-AVNITAARLLVNPDPPPYSLPYGYVT--QRDNIVYESSDPPRTLIHDLI 310
               ..::::.|.... ..|:|..:|:....|....|...:.|  ||:   |..|:.|......|.
Frog   243 ---GFKDISLDRFMHGGANVTGFQLVDFNTPIVTELMQRWKTLDQRE---YPGSESPPKYTSALT 301

  Fly   311 HDALQLFAQSWRNASFFYPDRMVVPRITCDFAASG---------GRTWAMGRYLARLMKGT--SG 364
            :|.:.:.|:::|          ::.|...|.:..|         ...|..|..:.|.:|..  .|
Frog   302 YDGVLVMAEAFR----------ILRRQKIDLSRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQG 356

  Fly   365 VNNTNFRTSILQFDEDGQRITFNIEVYDPLDGIG---IAIWDPRGQITQL------NVDVKAQKK 420
            :      |..:|||..|:|:.:.::|.: |...|   |..|:...::..|      ..|....:.
Frog   357 L------TGNIQFDHYGRRVNYTMDVLE-LKSNGLRKIGYWNDMDKLVLLQHEPAFKNDSSGIEN 414

  Fly   421 MIYRVATRIGPPYFSYNETARELNLTGNALYQGYAVDLIDAIARHVGFEYVFVPVADQQYGKLDK 485
            ....|.|.:..||..|.:. .|| |.||..::||.|||...||:|:|.:|....|.|.:||..|.
Frog   415 RTVIVTTILEAPYVMYKKN-HEL-LEGNDKFEGYCVDLAYEIAKHIGIKYKIAIVPDGKYGARDS 477

  Fly   486 ETKQWNGIIGEIINNDAHMGICDLTITQARKTAVDFTVPFMQLGVSILAYKSPHVEKTLDAYLAP 550
            |||.|||::||::...|.:.:..||||..|:..:||:.|||.||:||:..|....:..:.::|.|
Frog   478 ETKIWNGMVGELVYGKAEIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDP 542

  Fly   551 FGGEVWIWIL---ISVFVMTFLKTIVARISKMDW--ENPH-----PCNRDPEVLENQWRIHNTGW 605
            ...|:|:.|:   |.|.|:.||   |:|.|..:|  |.|.     |.::.|    |::.|.|:.|
Frog   543 LAYEIWMCIVFAYIGVSVVLFL---VSRFSPYEWHTEEPEDGKEGPSDQPP----NEFGIFNSLW 600

  Fly   606 LTVASIMTAGCDILPRSPQVRMFEATWWIFAIIIANSYTANLAAFLTSSKMEGSIANLKDLSAQK 670
            .::.:.|..||||.|||...|:....||.|.:||.:|||||||||||..:|...|.:.:||:.|.
Frog   601 FSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQT 665

  Fly   671 KVKFGTIYGGSTYNLLADSNETVYRLAFNLMNNDDPSAYTKDNLEGVDRVRKNRGDYMFLMETTT 735
            ::.:||:..|||......|...||...:..|.:.:||.:||...|||.||||::|.:.||:|:|.
Frog   666 EIAYGTLDAGSTKEFFKRSKIAVYEKMWTYMKSAEPSVFTKTTAEGVARVRKSKGKFAFLLESTM 730

  Fly   736 LEY-HREQNCDLRSVGEKFGEKHYAIAVPFGAEYRSNLSVAILKLSERGELYDLKQKWWKNPNAS 799
            .|| .:.:.||...||.....|.|.:|.|..::.|:.:::|:|||:|:|.|..||.|||.: ...
Frog   731 NEYIEQRKPCDTMKVGGNLDSKGYGVATPKHSQLRNAVNLAVLKLNEQGLLDKLKNKWWYD-KGE 794

  Fly   800 CFE--EPDPDATPDMTFEELRGIFYTLYAGILIAFLIGITEFLVYVQQVALEERLTFKDAFKKEI 862
            |..  ....|.|..::...:.|:||.|..|:.:|.|:.:.||....:..|...:|||.:|.:.:.
Frog   795 CGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKLTFSEAIRNKA 859

  Fly   863 R 863
            |
Frog   860 R 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIC	NP_608557.4	PBP1_iGluR_Kainate	26..404	CDD:107377	90/404 (22%)
		Periplasmic_Binding_Protein_Type_1	<279..363	CDD:299141	18/96 (19%)
		PBP2_iGluR_Kainate	423..794	CDD:270432	148/381 (39%)
		Lig_chan	554..828	CDD:278489	105/286 (37%)
gria4	XP_031751480.1	PBP1_iGluR_AMPA_GluR4	28..400	CDD:380611	90/412 (22%)
gria4	XP_031751480.1	PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	149/390 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.100