Protein Alignment PNUTS and Ppp1r10

DIOPT Version :10

• Sequence 1: NP_001014453.1
• Gene: PNUTS / 33270
• FlyBaseID: FBgn0053526
• Length: 1135
• Species: Drosophila melanogaster
• Sequence 2: NP_075240.1
• Gene: Ppp1r10 / 65045
• RGDID: 620079
• Length: 872
• Species: Rattus norvegicus
• Alignment Length: 1242
• Identity: 294/1242 - (23%)
• Similarity: 412/1242 - (33%)
• Gaps: 498/1242 - (40%)

  Fly     4 IVPLQLLRCLRVLLDNNGGILSAVEVKRISGLMAKYSKKLVSKCVYVQILKSTKT-ELLGDFMAV 67
            |.|.:||:.|...|..:|.:.|...:.:|..|| |.::|:||:|.|:.|:..|:. |:|..|:.|
  Rat     6 IDPKELLKGLDSFLTRDGEVKSVDGIAKIFSLM-KEARKMVSRCTYLNIILQTRAPEVLVKFIDV 69

  Fly    68 GGWSLVYTWLNDAIRAMNWPLVQEILELLLLSPVDVNRLKINSAPILVKGLCKDGGNEGVRILAK 132
            ||:.|:.:||..:....|.||:|:||..|...|:.|:.||.|:...|||.|.|...:|.:|.||.
  Rat    70 GGYKLLNSWLTYSKTTNNIPLLQQILLTLQHLPLTVDHLKQNNTAKLVKQLSKSSEDEELRKLAS 134

  Fly   133 RLVEQWLKIVTENTSMTIQGAAPHIAATTASQVPASVSGAGSASVPDSASSSDSTDSAGAPVTYT 197
            .||..|:.::
  Rat   135 VLVSDWMAVI------------------------------------------------------- 144

  Fly   198 ITSAANSSNSNSITIKWKPLLDNPDGGDETDSGTQSKDNEVEHLEKGSSATHLLADASLGKKSGL 262
                                                                             
  Rat   145 ----------------------------------------------------------------- 144

  Fly   263 DDSSSAAEVKSGEDVDNKKHKSSKSDKSKRSEKEREKDRKKESSSHRSSSSSHKSSSSSSSSSSK 327
                                      :|:.|.:..|||:||.
  Rat   145 --------------------------RSQSSTQPAEKDKKKR----------------------- 160

  Fly   328 SSSSKSSSSSSSSHRSSSDKYRDKDKARSSSGSSSSSKDRERSSGSSSSSSNKHKSSKSSSSSSS 392
                                 :::.|:|::.        .||
  Rat   161 ---------------------KEEGKSRTTL--------PER----------------------- 173

  Fly   393 SSSSSSGSSSSKDRKSSSSTSSSSSSSRQDKDKDNKLMPPPAVAASNAAGTSPTASAKESDAQKP 457
                                                  |...|.|...|..:|     |...:||
  Rat   174 --------------------------------------PLTEVKAETRAEEAP-----EKKKEKP 195

  Fly   458 RSIPIMSRKASISIEIRRDTEKTATVKTYQSKFRSHGLTEEAPPPPSRKGLKKPTSSAVAASPAL 522
            :|:                    .|.....:||||.||..:.   ||...:|| .||.|..|...
  Rat   196 KSL--------------------RTTAPSHAKFRSTGLELDT---PSLVPVKK-NSSTVVVSDKY 236

  Fly   523 MAVPSSLKRPS--PPPRDLSTDKKAKIDINNVAGHVERPGAAKLIAPKKIQTLVETNLFSDALAA 585
            ...|..|||.|  ..|.|.:...:.|....|...:..:....|:|.|:.::.|.    |.|||.:
  Rat   237 NLKPIPLKRQSATAAPGDAAPPAEKKYKPLNTTPNTTKEIKVKIIPPQPMEGLG----FLDALNS 297

  Fly   586 SIEPKKVVKRKRTSATSPTDKDAPLAPLKFYQDTLDESKSEEKSDDSSKENDDARSSSP------ 644
            :..|...:|:|:...:....|.:|.           |.|       :|.|...|:.|||
  Rat   298 APVPGIKIKKKKKVLSPTAAKPSPF-----------EGK-------TSTEPSTAKPSSPEPAAPA 344

  Fly   645 -GKDTDADDDDIPLKRVKEDIEQKVQKAKAAAGGEGGEAGNTSDNAEDLPEEP-KKPGPGCGPDG 707
             ..|||.....:|...|.|.::        ||..|.|.          |..:| :.|       |
  Rat   345 EPMDTDRPGTPVPAVEVPELMD--------AASSEPGA----------LDAKPVESP-------G 384

  Fly   708 PPGVLTLHRRKGPKKK-LTWQSEEKLTQIRYFEVDRSERVNVMK-QTFLEMKNMERFSERDALTI 770
            .|..||   |||.|:| :||..|.||.:..|||:|.:|||||.| :.|.|....|..|:|.|...
  Rat   385 DPNQLT---RKGRKRKTVTWPEEGKLREYFYFELDETERVNVNKIKDFGEAAKREILSDRHAFET 446

  Fly   771 ARRGFDDTMEPQMEW---RPLLEVDNVPDH---PNGNLSKQRQVQMDREATTLRALYFSPDMIPD 829
            |||...|.||.::.|   |||:    :|..   |..| |::|.:|.:||...|:.|:.:    .:
  Rat   447 ARRLSHDNMEEKVPWVCPRPLV----LPSPLVIPGSN-SQERYIQAEREKGILQELFLN----KE 502

  Fly   830 SPAEAELEPHFAHDIP--VIPMD-----DLT------------GNPDAVNDYSALAWPEPKKYAP 875
            ||.|.:.||:  ..||  :||:|     |.|            |:||.... |.|. |.......
  Rat   503 SPHEPDPEPY--EPIPPKLIPLDEECAMDETPYVETLEPGGSGGSPDGAGG-SKLP-PVLANLMG 563

  Fly   876 SSGVGANISG-SDMGFN-DNMLTGLGAGPN-------LMQNPFDPFMGGMPAPTG-MPPGPNMMP 930
            |.|.|.:..| ...|.| ..:||.:...||       |.|..:...:..|..|.| :.|||
  Rat   564 SMGAGKSPQGPGGGGINVQEILTSIMGSPNNHPSEELLKQPDYSDKLKQMLVPHGLLGPGP---- 624

  Fly   931 NQVPNGTPQIWQNQMGPVGGPPGVPPMMNGPGGPGMDMSNMNMNNMPPQNFMGNQFGSPVSPFGS 995
              |.||.|.      |..|||.|:.....|||||           ||..:  |.. |.||.|...
  Rat   625 --VANGFPP------GGPGGPKGMQHFPPGPGGP-----------MPGPH--GGP-GGPVGPRLL 667

  Fly   996 GPPP---GFNQY-----PPM----MMNGPGPGPVMGP----------NGPVMGPNGPMMNGPPNG 1038
            ||||   |.:.:     .||    |..||||||  ||          |.|   |..|...|...|
  Rat   668 GPPPPSRGGDPFWDGPGDPMRGGPMRGGPGPGP--GPYHRGRGGRGGNEP---PPPPPFRGARGG 727

  Fly  1039 PMMNGPPNGM---GPGLMMG--------GPRNNNNNNNRNKNNGGGIWRSGGNNFQ--------- 1083
            ....|||||.   |.|.|:|        ||..:..:.:|:....||...||..:.:
  Rat   728 RSGGGPPNGRGGPGGGGMVGGGGHRPHEGPGGSMGSGHRSHEGPGGSMGSGHRSHEGPGHGGPHG 792

  Fly  1084 -------ENSGGNWRSA-----------GSGPNRGGGGGNGNTG------VCKQF-MRGHCNMGK 1123
                   .:.|.:.|..           |.|.:||..||:.:.|      ||:.| |:|:|....
  Rat   793 HRPHDVPSHRGHDHRGPPPHEHRGHDGHGGGGHRGHDGGHSHGGDMSNRPVCRHFMMKGNCRYEN 857

  Fly  1124 NCKYVHP 1130
            ||.:.||
  Rat   858 NCAFYHP 864

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PNUTS	NP_001014453.1	Med26	91..142	CDD:462573	20/50 (40%)
		PTZ00449	<425..>644	CDD:185628	52/220 (24%)
		ZnF_C3H1	1110..1130	CDD:214632	8/20 (40%)
Ppp1r10	NP_075240.1	Interaction with TOX4. /evidence=ECO:0000250|UniProtKB:Q80W00	1..348		117/652 (18%)
		TFIIS_I	<102..146	CDD:469629	17/189 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	147..213		24/203 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	247..270		5/22 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	307..398		32/136 (24%)
		Necessary for interaction with PPP1CA. /evidence=ECO:0000269|PubMed:9461602	357..433		36/103 (35%)
		Necessary for interaction with PPP1CC. /evidence=ECO:0000250|UniProtKB:Q96QC0	393..408		7/14 (50%)
		PP1-binding motif. /evidence=ECO:0000269|PubMed:24591642	394..423		14/28 (50%)
		Interaction with WDR82. /evidence=ECO:0000250|UniProtKB:Q80W00	418..619		64/213 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	534..837		91/335 (27%)
		zf-CCCH	841..864	CDD:459885	8/22 (36%)