Protein Alignment PNUTS and Ppp1r10

DIOPT Version :10

• Sequence 1: NP_001014453.1
• Gene: PNUTS / 33270
• FlyBaseID: FBgn0053526
• Length: 1135
• Species: Drosophila melanogaster
• Sequence 2: NP_001157290.1
• Gene: Ppp1r10 / 52040
• MGIID: 1289273
• Length: 888
• Species: Mus musculus
• Alignment Length: 1259
• Identity: 296/1259 - (23%)
• Similarity: 408/1259 - (32%)
• Gaps: 516/1259 - (40%)

  Fly     4 IVPLQLLRCLRVLLDNNGGILSAVEVKRISGLMAKYSKKLVSKCVYVQILKSTKT-ELLGDFMAV 67
            |.|.:||:.|...|..:|.:.|...:.:|..|| |.::|:||:|.|:.|:..|:. |:|..|:.|
Mouse     6 IDPKELLKGLDSFLTRDGEVKSVDGISKIFSLM-KEARKMVSRCTYLNIILQTRAPEVLVKFIDV 69

  Fly    68 GGWSLVYTWLNDAIRAMNWPLVQEILELLLLSPVDVNRLKINSAPILVKGLCKDGGNEGVRILAK 132
            ||:.|:..||..:....|.||:|:||..|...|:.|:.||.|:...|||.|.|...:|.:|.||.
Mouse    70 GGYKLLNNWLTYSKTTNNIPLLQQILLTLQHLPLTVDHLKQNNTAKLVKQLSKSSEDEELRKLAS 134

  Fly   133 RLVEQWLKIVTENTSMTIQGAAPHIAATTASQVPASVSGAGSASVPDSASSSDSTDSAGAPVTYT 197
            .||..|:.::
Mouse   135 VLVSDWMAVI------------------------------------------------------- 144

  Fly   198 ITSAANSSNSNSITIKWKPLLDNPDGGDETDSGTQSKDNEVEHLEKGSSATHLLADASLGKKSGL 262
                                                                             
Mouse   145 ----------------------------------------------------------------- 144

  Fly   263 DDSSSAAEVKSGEDVDNKKHKSSKSDKSKRSEKEREKDRKKESSSHRSSSSSHKSSSSSSSSSSK 327
                                      :|:.|.:..|||:||.
Mouse   145 --------------------------RSQSSTQPAEKDKKKR----------------------- 160

  Fly   328 SSSSKSSSSSSSSHRSSSDKYRDKDKARSSSGSSSSSKDRERSSGSSSSSSNKHKSSKSSSSSSS 392
                                 :::.|:|::.        .||
Mouse   161 ---------------------KEEGKSRTTL--------PER----------------------- 173

  Fly   393 SSSSSSGSSSSKDRKSSSSTSSSSSSSRQDKDKDNKLMPPPAVAASNAAGTSPTASAKESDAQKP 457
                                                  |...|.|...|..:|     |...:||
Mouse   174 --------------------------------------PLTEVKAETRAEEAP-----EKKKEKP 195

  Fly   458 RSIPIMSRKASISIEIRRDTEKTATVKTYQSKFRSHGLTEEAPPPPSRKGLKKPTSSAVAASPAL 522
            :|:                    .|.....:||||.||..:.   ||...:|| .||.|..|...
Mouse   196 KSL--------------------RTTAPSHAKFRSTGLELDT---PSLVPVKK-NSSTVVVSDKY 236

  Fly   523 MAVPSSLKRPS--PPPRDLSTDKKAKIDINNVAGHVERPGAAKLIAPKKIQTLVETNLFSDALAA 585
            ...|..|||.|  ..|.|.:...:.|....|.|.:..:....|:|.|:.::.|.    |.|||.:
Mouse   237 NLKPIPLKRQSATAAPGDAAPPAEKKYKPLNTAPNTTKEIKVKIIPPQPMEGLG----FLDALNS 297

  Fly   586 SIEPKKVVKRKRTSATSPTDKDAPLAPLKFYQDTLDESKSEEKSDDSSKENDDARSSSP------ 644
            :..|...:|:|:...:....|.:|.           |.|       :|.|...|:.|||
Mouse   298 APVPGIKIKKKKKVLSPTAAKPSPF-----------EGK-------TSTEQSTAKPSSPEPAPPA 344

  Fly   645 -GKDTDADDDDIPLKRVKEDIEQKVQKAKAAAGGEGGEAGNTSDNAEDLPEEPKKPGPGCGPDGP 708
             ..|||.....:|...|.|.::        ||..|.|.          |..:|      ....|.
Mouse   345 EPMDTDRPGTPVPPVEVPELMD--------AASSEPGA----------LDAKP------VDSPGD 385

  Fly   709 PGVLTLHRRKGPKKK-LTWQSEEKLTQIRYFEVDRSERVNVMK-QTFLEMKNMERFSERDALTIA 771
            |..||   |||.|:| :||..|.||.:..|||:|.:|||||.| :.|.|....|..|:|.|...|
Mouse   386 PNQLT---RKGRKRKTVTWPEEGKLREYFYFELDETERVNVNKIKDFGEAAKREILSDRHAFETA 447

  Fly   772 RRGFDDTMEPQMEW---RPLLEVDNVPDH---PNGNLSKQRQVQMDREATTLRALYFSPDMIPDS 830
            ||...|.||.::.|   |||:    :|..   |..| |::|.:|.:||...|:.|:.:    .:|
Mouse   448 RRLSHDNMEEKVPWVCPRPLV----LPSPLVIPGSN-SQERYIQAEREKGILQELFLN----KES 503

  Fly   831 PAEAELEPHFAHDIP--VIPMD-----DLT------------GNPDAVNDYSALAWPEPKKYAPS 876
            |.|.:.||:  ..||  :||:|     |.|            |:||.... |.|. |.......|
Mouse   504 PHEPDPEPY--EPIPPKLIPLDEECAMDETPYVETLEPGGSGGSPDGAGG-SKLP-PVLANLMGS 564

  Fly   877 SGVGANISG-SDMGFN-DNMLTGLGAGPN-------LMQNPFDPFMGGMPAPTG-MPPGPNMMPN 931
            .|.|.:..| ...|.| ..:||.:...||       |.|..:...:..|..|.| :.|||
Mouse   565 MGAGKSPQGPGGGGINVQEILTSIMGSPNSHPSEELLKQPDYSDKLKQMLVPHGLLGPGP----- 624

  Fly   932 QVPNGTPQIWQNQMGPVGGPPGVPPMMNGPGGPGMDMSNMNMNNMPPQNFMGNQFGSPVSPFGSG 996
             |.||.|.      |..|||.|:.....|||||           ||..:  |.. |.||.|...|
Mouse   625 -VANGFPP------GGPGGPKGMQHFPPGPGGP-----------MPGPH--GGP-GGPVGPRLLG 668

  Fly   997 PPPGFNQYPPM-------MMNGP---GPGPVMGP----------NGPVMGPNGPMMNGPPNGPMM 1041
            |||......|.       |..||   ||||..||          |.|   |..|...|...|...
Mouse   669 PPPPSRGGDPFWDGPGDPMRGGPMRGGPGPAPGPYHRGRGGRGGNEP---PPPPPFRGARGGRSG 730

  Fly  1042 NGPPNGM------------------GPGLMMG-------GPRNNNNNNNRNKNN-GGGIWRSGGN 1080
            .|||||.                  |||..||       ||..|..:.:|:.:. ||.:..|||:
Mouse   731 GGPPNGRGGPGGGGMVGGGGHRPHEGPGGSMGSGHRSHDGPGGNMGSGHRSHDGPGGNMGGSGGH 795

  Fly  1081 NFQENSG--------------------------------GNWRSAGSGPNRGGGGGNGNTG---- 1109
            ...|..|                                |:    |.|.:||..||:.:.|
Mouse   796 RSHEGPGHGGPHGHRPHDVPSHRGHDHRGPPPHEHRGHDGH----GGGGHRGHDGGHSHGGDMSN 856

  Fly  1110 --VCKQF-MRGHCNMGKNCKYVHP 1130
              ||:.| |:|:|....||.:.||
Mouse   857 RPVCRHFMMKGNCRYENNCAFYHP 880

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PNUTS	NP_001014453.1	Med26	91..142	CDD:462573	20/50 (40%)
		PTZ00449	<425..>644	CDD:185628	53/220 (24%)
		ZnF_C3H1	1110..1130	CDD:214632	8/20 (40%)
Ppp1r10	NP_001157290.1	Interaction with TOX4. /evidence=ECO:0000269|PubMed:20516061	1..348		118/652 (18%)
		TFIIS_I	<102..146	CDD:469629	17/189 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	147..213		24/203 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	247..270		5/22 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	306..400		33/138 (24%)
		Necessary for interaction with PPP1CA. /evidence=ECO:0000269|PubMed:20516061	388..417		15/31 (48%)
		Necessary for interaction with PPP1CC. /evidence=ECO:0000250|UniProtKB:Q96QC0	393..408		7/14 (50%)
		PP1-binding motif. /evidence=ECO:0000250|UniProtKB:O55000	394..423		14/28 (50%)
		Interaction with WDR82. /evidence=ECO:0000269|PubMed:20516061	418..619		64/213 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	534..853		93/353 (26%)
		zf-CCCH	857..880	CDD:459885	8/22 (36%)