DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment aru and Eps8l3

DIOPT Version :9

Sequence 1:	NP_722663.1	Gene:	aru / 33268	FlyBaseID:	FBgn0029095	Length:	805	Species:	Drosophila melanogaster
Sequence 2:	XP_006502526.2	Gene:	Eps8l3 / 99662	MGIID:	2139743	Length:	649	Species:	Mus musculus

Alignment Length:	704	Identity:	162/704 - (23%)
Similarity:	252/704 - (35%)	Gaps:	206/704 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 RERLESDLHDKPTYL---LEHLATFTVNKESGIVYPADGMRRLLQLEKTTGIWSQKMQLCLDYQW 134
            |:.....:..:||.|   :|||.|..:..:. :..|.|.:::|.:::....:|||.:.|.:...|
Mouse    13 RKEYSQSMASEPTLLQHRVEHLMTCKLGTQR-VREPKDALQKLQEMDAQGRVWSQDLFLQVRDGW 76

  Fly   135 VLIMDYETGNIIERFPASLVQEPTAFTSNDAMEL------YNNILVFIVSGGGGSRSEMHIFQSQ 193
            :.::|.||...::.:....::         |:::      ||:||...|...|.......:||.|
Mouse    77 LHLLDIETKEELDSYRLDNIK---------AIDVALNTCSYNSILSVTVQESGLPGISTLLFQCQ 132

  Fly   194 SVSAVHLVEDLKQLRSGKMITQQRGAT--PTQSGGGGASSMAMMMSKTSSSSSHSRVELHQHREQ 256
            .|.|..|...|::....::..:.|...  |:|....|......:           .::.....||
Mouse   133 EVGAEQLRTSLQKALEEELEERPRFGVHHPSQDRWKGPPLERPL-----------PIQQAPPLEQ 186

  Fly   257 RAERERERDRDRERESHHHMHQRSSMEQYGIRAGVGVSGDDVAHISGETDSEHGGIGGGGATERD 321
            |...|.   |....:.|:...:||          :..|...:.|.....:.      .|......
Mouse   187 RFSPEH---RFPPEQPHNMTSERS----------ISPSSRSLTHYPSAREP------NGFTLPPP 232

  Fly   322 ETSSTSSEKYERDVAVLNHCFDDIEKFIARLQHAAAASRELERRRRNRKSKKRDPGEGLLTLRTR 386
            ...:.|.|..|||..||||...|||.|..:|:...|.:.. ::.:..||.||...|   :|
Mouse   233 PRRAPSPEDPERDEEVLNHVLRDIELFAGKLKEVQARNSH-KKTKLGRKKKKSKNG---IT---- 289

  Fly   387 PPHEKEFVDIFAKFKLSFNLLAKLKAHIHDPNAPELVHFLFTPLALIVEASSDTYYESQLPARVV 451
               :.|::|.|.|.|||||||.||...:.:.:|||.|..:|..|..|:....    |:.|||:|:
Mouse   290 ---QAEYIDCFQKIKLSFNLLGKLALRMQETSAPEFVGLIFQTLKFILSQCP----EAGLPAKVI 347

  Fly   452 NPLLTREAINLLINCVTSKETELWRSLGDAWVIPRDQWKDDVGS----YHPVFLDGWSPDYLIND 512
            :||||.:||:||.:|::..|..||:|||.:|.   ..|.|..||    |.|.|.|||
Mouse   348 SPLLTPKAIDLLQSCLSPPEDTLWKSLGTSWT---TSWADWTGSEPPPYQPTFYDGW-------- 401

  Fly   513 ELEPPPNSPPAHVSKRRLEVQAGSGLNGRGGGGYDDYDSGNGMNMAMGIEKYTIHHGNDGLRERE 577
            ::..|.:..|                       ..:.||
Mouse   402 QIPQPRSMMP-----------------------ITNQDS-------------------------- 417

  Fly   578 RERDRERAGAISASDFNARSELSFDSIEGRGGGAAGHGHGHGHGPGAGPTLSAITAGLQNLHTRE 642
                      ||......||.|.|...|           .:.|.|                   |
Mouse   418 ----------ISLRGSRMRSSLHFPRDE-----------PYNHNP-------------------E 442

  Fly   643 SRSGNGYGAGAGPGPSSELGGGGRGLPNVSDDQMLESWLEDLQATGAKIVLVTYPRTANNDKELS 707
            ....|...:...||                              ..|..:.|.|...|.|.:||:
Mouse   443 YEDSNLPLSSPSPG------------------------------RAALKMQVLYEFEARNAQELT 477

  Fly   708 VMRGEYLEILDDTRKWWKARNMRGQVAHVPHTIVTPFNFGDGDGAQFYGQQQQP 761
            |.:||.||:||.:::||..:|..|...::|..|:.|...|...|      .:||
Mouse   478 VAQGEILEVLDQSKRWWLVKNEAGLTGYIPSNILEPLPAGAPRG------HRQP 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aru	NP_722663.1	PTB_EPS8	82..215	CDD:269921	32/141 (23%)
aru	NP_722663.1	SH3_Eps8	691..744	CDD:212698	19/52 (37%)
Eps8l3	XP_006502526.2	PTB_EPS8	25..146	CDD:269921	31/130 (24%)
		SH3_Eps8	462..514	CDD:212698	19/51 (37%)
		SAM_superfamily	531..596	CDD:387673
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841872
Domainoid	1	1.000	63	1.000	Domainoid score	I10184
eggNOG	1	0.900	-	-		E1_KOG3557
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44182
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12287
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.800