Protein Alignment aru and eps8l2

DIOPT Version :10

• Sequence 1: NP_722663.1
• Gene: aru / 33268
• FlyBaseID: FBgn0029095
• Length: 805
• Species: Drosophila melanogaster
• Sequence 2: XP_002666818.3
• Gene: eps8l2 / 798252
• ZFINID: ZDB-GENE-131121-340
• Length: 670
• Species: Danio rerio
• Alignment Length: 740
• Identity: 189/740 - (25%)
• Similarity: 284/740 - (38%)
• Gaps: 235/740 - (31%)

  Fly    71 EERERLESD---LHDKPTYLLEHLATFTVNKESGIVYPADGMRRLLQLEKTTGIWSQKMQLCLDY 132
            |:|::..:.   :.:...|.::||:||.::|...|....|.:::|..|:....||:|:|.|.:..
Zfish    28 EQRKKYSNSNVIMQETSQYHVQHLSTFVMDKTEAIATVDDAIKKLKLLDSKDKIWTQEMLLQVTD 92

  Fly   133 QWVLIMDYETGNIIERFPASLVQEPTAFTSNDAMELYNNILVFIVSGGGGSRSEMHIFQSQSVSA 197
            :.:.::|.||...:|.||.:.|.......:...   |.::|:.:.......:.::|.|....|.|
Zfish    93 KSIKLLDCETKEELENFPLATVHHCQTLLNQTR---YPSVLLLVCQDNEQHKPDIHFFYCDEVEA 154

  Fly   198 VHLVEDLKQLRSGKMITQQRGATPTQSGGGGASSMAMMMSKTSSSSSHSRVELHQHREQRAERER 262
            ..:..|:                 ..:.|..|....|                   |.|..:..:
Zfish   155 EMVHADI-----------------DSALGDNARGKKM-------------------RPQTLKLNQ 183

  Fly   263 ERDRDRERESHHHMHQRSSMEQYGIRAGVGVSGDDVAHISGETDSEHGGIGGG-GATE-RDETSS 325
            |:.:          |||.|:                  |.....|...|:.|. .||: :||.|.
Zfish   184 EKMK----------HQRESI------------------IPPSEPSPGPGVKGRVAATDMKDELSM 220

  Fly   326 TSSE-------KYERDVAVLNHCFDDIEKFIARLQHAAAASRELERRRRNRKSKKRDPGEGLLTL 383
            ...|       :.|:||.:||...||||.|:|||..||.|..:|.:|.|::|:|||.|.||:|||
Zfish   221 QDPESNMKLAQRIEKDVQILNCSLDDIEIFVARLHKAAEAFAQLNQRNRSKKNKKRGPAEGMLTL 285

  Fly   384 RTRPPHEKEFVDIFAKFKLSFNLLAKLKAHIHDPNAPELVHFLFTPLALIVEASSDTYYESQLPA 448
            |.:||.|.||||...|.|||||||||||.||.:|||.||:||||.||.||:::|.    ...||.
Zfish   286 RAKPPSEAEFVDCLQKLKLSFNLLAKLKKHIQNPNASELIHFLFGPLELILQSSG----SPDLPR 346

  Fly   449 RVVNPLLTREAINLLINCVTSKETELWRSLGDAWVIPRDQWKDD--VGSYHPVFLDGWSPDYLIN 511
            .|::|.|:|:|::.|...:|.||..::..|||.|..||..|..|  ...|.|.|.:||
Zfish   347 AVISPHLSRDAVDFLRGHLTPKEMTIFELLGDGWTRPRADWPKDQCAPLYVPKFRNGW------- 404

  Fly   512 DELEPPPNSPPAHVSKRRLEVQAGSGLNGRGGGGYDDYDSGNGMNMAMGIEKYTIHHGNDGLRER 576
               |||            :|:                :.:......::|:.|..:         :
Zfish   405 ---EPP------------VEL----------------FRTSPWETESIGMPKSPV---------Q 429

  Fly   577 ERERDRERAGAISASDFNARSELSFDSIEGRGGGAAGHGHGHGHGPGAGPTLSAITAGLQNLHTR 641
            ...|.:|..|:.|:...|                            |:.|
Zfish   430 SEYRSKEFFGSQSSPSSN----------------------------GSYP--------------- 451

  Fly   642 ESRSGNGYGAGAGPGPSSELGGGGRGLPNVSDDQMLESWLEDLQATGAKIVLVTYPRTANNDKEL 706
                         |.|:..                             |...:.|...|.|..||
Zfish   452 -------------PSPAPR-----------------------------KYAKIRYHFVARNANEL 474

  Fly   707 SVMRGEYLEILDDTRKWWKARNMRGQVAHVPHTIVTPFNFGDGDGAQFYGQQQQPPTGPTGPGNK 771
            ||::.|.||:|:|.::|||.||..||..:||:.|:......|...      ...||..|
Zfish   475 SVLQDEILEVLEDGKQWWKLRNRSGQAGYVPYNILDVIKLEDPQA------MIDPPYSP------ 527

  Fly   772 SRSGDNPGMEQRSPDPTDMMRSKHL 796
            |..|.:|...|.|.      :..||
Zfish   528 SYRGQSPSGSQGSD------KDSHL 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aru	NP_722663.1	PTB_EPS8	82..215	CDD:269921	29/132 (22%)
		SH3_Eps8	691..744	CDD:212698	22/52 (42%)
eps8l2	XP_002666818.3	None