DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aru and eps8l2

DIOPT Version :9

Sequence 1:	NP_722663.1	Gene:	aru / 33268	FlyBaseID:	FBgn0029095	Length:	805	Species:	Drosophila melanogaster
Sequence 2:	XP_002666818.2	Gene:	eps8l2 / 798252	ZFINID:	ZDB-GENE-131121-340	Length:	670	Species:	Danio rerio

Alignment Length:	740	Identity:	189/740 - (25%)
Similarity:	284/740 - (38%)	Gaps:	235/740 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 EERERLESD---LHDKPTYLLEHLATFTVNKESGIVYPADGMRRLLQLEKTTGIWSQKMQLCLDY 132
            |:|::..:.   :.:...|.::||:||.::|...|....|.:::|..|:....||:|:|.|.:..
Zfish    28 EQRKKYSNSNVIMQETSQYHVQHLSTFVMDKTEAIATVDDAIKKLKLLDSKDKIWTQEMLLQVTD 92

  Fly   133 QWVLIMDYETGNIIERFPASLVQEPTAFTSNDAMELYNNILVFIVSGGGGSRSEMHIFQSQSVSA 197
            :.:.::|.||...:|.||.:.|.......:...   |.::|:.:.......:.::|.|....|.|
Zfish    93 KSIKLLDCETKEELENFPLATVHHCQTLLNQTR---YPSVLLLVCQDNEQHKPDIHFFYCDEVEA 154

  Fly   198 VHLVEDLKQLRSGKMITQQRGATPTQSGGGGASSMAMMMSKTSSSSSHSRVELHQHREQRAERER 262
            ..:..|:                 ..:.|..|....|                   |.|..:..:
Zfish   155 EMVHADI-----------------DSALGDNARGKKM-------------------RPQTLKLNQ 183

  Fly   263 ERDRDRERESHHHMHQRSSMEQYGIRAGVGVSGDDVAHISGETDSEHGGIGGG-GATE-RDETSS 325
            |:.:          |||.|:                  |.....|...|:.|. .||: :||.|.
Zfish   184 EKMK----------HQRESI------------------IPPSEPSPGPGVKGRVAATDMKDELSM 220

  Fly   326 TSSE-------KYERDVAVLNHCFDDIEKFIARLQHAAAASRELERRRRNRKSKKRDPGEGLLTL 383
            ...|       :.|:||.:||...||||.|:|||..||.|..:|.:|.|::|:|||.|.||:|||
Zfish   221 QDPESNMKLAQRIEKDVQILNCSLDDIEIFVARLHKAAEAFAQLNQRNRSKKNKKRGPAEGMLTL 285

  Fly   384 RTRPPHEKEFVDIFAKFKLSFNLLAKLKAHIHDPNAPELVHFLFTPLALIVEASSDTYYESQLPA 448
            |.:||.|.||||...|.|||||||||||.||.:|||.||:||||.||.||:::|.    ...||.
Zfish   286 RAKPPSEVEFVDCLQKLKLSFNLLAKLKKHIQNPNASELIHFLFGPLELILQSSG----SPDLPR 346

  Fly   449 RVVNPLLTREAINLLINCVTSKETELWRSLGDAWVIPRDQWKDD--VGSYHPVFLDGWSPDYLIN 511
            .|::|.|:|:|::.|...:|.||..::..|||.|..||..|..|  ...|.|.|.:||
Zfish   347 AVISPHLSRDAVDFLRGHLTPKEMTIFELLGDGWTRPRADWPKDQCAPLYVPKFRNGW------- 404

  Fly   512 DELEPPPNSPPAHVSKRRLEVQAGSGLNGRGGGGYDDYDSGNGMNMAMGIEKYTIHHGNDGLRER 576
               |||            :|:                :.:......::|:.|..:         :
Zfish   405 ---EPP------------VEL----------------FRTSPWETESIGMPKSPV---------Q 429

  Fly   577 ERERDRERAGAISASDFNARSELSFDSIEGRGGGAAGHGHGHGHGPGAGPTLSAITAGLQNLHTR 641
            ...|.:|..|:.|:...|                            |:.|
Zfish   430 SEYRSKEFFGSQSSPSSN----------------------------GSYP--------------- 451

  Fly   642 ESRSGNGYGAGAGPGPSSELGGGGRGLPNVSDDQMLESWLEDLQATGAKIVLVTYPRTANNDKEL 706
                         |.|:..                             |...:.|...|.|..||
Zfish   452 -------------PSPAPR-----------------------------KYAKIRYHFVARNANEL 474

  Fly   707 SVMRGEYLEILDDTRKWWKARNMRGQVAHVPHTIVTPFNFGDGDGAQFYGQQQQPPTGPTGPGNK 771
            ||::.|.||:|:|.::|||.||..||..:||:.|:......|...      ...||..|
Zfish   475 SVLQDEILEVLEDGKQWWKLRNRSGQAGYVPYNILDVIKLEDPQA------MIDPPYSP------ 527

  Fly   772 SRSGDNPGMEQRSPDPTDMMRSKHL 796
            |..|.:|...|.|.      :..||
Zfish   528 SYRGQSPSGSQGSD------KDSHL 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aru	NP_722663.1	PTB_EPS8	82..215	CDD:269921	29/132 (22%)
aru	NP_722663.1	SH3_Eps8	691..744	CDD:212698	22/52 (42%)
eps8l2	XP_002666818.2	PTB_EPS8	42..172	CDD:269921	31/149 (21%)
		SH3_Eps8	459..510	CDD:212698	22/50 (44%)
		SAM_EPS8-like	581..646	CDD:188939
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	65	1.000	Domainoid score	I10016
eggNOG	1	0.900	-	-		E1_KOG3557
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	283	1.000	Inparanoid score	I2853
OMA	1	1.010	-	-		QHG46652
OrthoDB	1	1.010	-	-		D118943at33208
OrthoFinder	1	1.000	-	-		FOG0001461
OrthoInspector	1	1.000	-	-		otm26432
orthoMCL	1	0.900	-	-		OOG6_106655
Panther	1	1.100	-	-	O	PTHR12287
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4036
SonicParanoid	1	1.000	-	-		X1022
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870