DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aru and EPS8L3

DIOPT Version :9

Sequence 1:	NP_722663.1	Gene:	aru / 33268	FlyBaseID:	FBgn0029095	Length:	805	Species:	Drosophila melanogaster
Sequence 2:	XP_011540434.1	Gene:	EPS8L3 / 79574	HGNCID:	21297	Length:	602	Species:	Homo sapiens

Alignment Length:	736	Identity:	176/736 - (23%)
Similarity:	270/736 - (36%)	Gaps:	229/736 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 RERLESDLHDKPTYL---LEHLATFTVNKESGIVYPADGMRRLLQLEKTTGIWSQKMQLCLDYQW 134
            |:....:|..:||.|   :|||.|.....:. :..|.|.:::|.:::....:|||.:.|.:...|
Human    13 RKEYSQNLTSEPTLLQHRVEHLMTCKQGSQR-VQGPEDALQKLFEMDAQGRVWSQDLILQVRDGW 76

  Fly   135 VLIMDYETGNIIERFPASLVQEPTAFTSNDAMEL--YNNILVFIVSGGGGSRSEMHIFQSQSVSA 197
            :.::|.||...::.:....:|     ..|.|:..  ||:||...|...|...:...:||.|.|.|
Human    77 LQLLDIETKEELDSYRLDSIQ-----AMNVALNTCSYNSILSITVQEPGLPGTSTLLFQCQEVGA 136

  Fly   198 VHLVEDLKQLRSGKMITQQRGATPTQSGGGGASSMAMMMSKTSSSSSHSRVELHQHREQRAERER 262
            ..|...|:     |.:.::...:..:.||                     ::..|.|.:....||
Human   137 ERLKTSLQ-----KALEEELEQSRPRLGG---------------------LQPGQDRWRGPAMER 175

  Fly   263 ERDRDRER---------ESHHHMHQRSSMEQYGIRAGVGVSGDDV-AHISGETDSEHGGIGGGGA 317
            ....::.|         :.|....:.|....|  .||:..|...: .|.|....|        ..
Human   176 PLPMEQARYLEPGIPPEQPHQRTLEHSPWSPY--TAGLPPSPRPLPRHTSAREPS--------AF 230

  Fly   318 TERDETSSTSSEKYERDVAVLNHCFDDIEKFIARLQHAAAASRELERRRRNRKSKKRDPGEGLLT 382
            |......|:|.|..|||..||||...|||.|:.:|:.|.|      :..|.:|..|::..:|.||
Human   231 TLPPPRRSSSPEDPERDEEVLNHVLRDIELFMGKLEKAQA------KTSRKKKFGKKNKDQGGLT 289

  Fly   383 LRTRPPHEKEFVDIFAKFKLSFNLLAKLKAHIHDPNAPELVHFLFTPLALIVEASSDTYYESQLP 447
                   :.:::|.|.|.|.|||||.:|...:.:.:||||||.||..|..|:....    |:.|.
Human   290 -------QAQYIDCFQKIKHSFNLLGRLATWLKETSAPELVHILFKSLNFILARCP----EAGLA 343

  Fly   448 ARVVNPLLTREAINLLINCVTSKETELWRSLGDAWVIPRDQWK-DDVGSYHPVFLDGWSPDYLIN 511
            |:|::||||.:|||||.:|::..|:.||..||.||...|..|. |:...|.|.|.|.|
Human   344 AQVISPLLTPKAINLLQSCLSPPESNLWMGLGPAWTTSRADWTGDEPLPYQPTFSDDW------- 401

  Fly   512 DELEPPPNSPPAHVSKRRLEVQAGSGLNGRGGGGYDDYDSGNGMNMAMGIEKYTIHHGNDGLRER 576
             :|..|.:..|.                     ||.|..|                     ||
Human   402 -QLPEPSSQAPL---------------------GYQDPVS---------------------LR-- 421

  Fly   577 ERERDRERAGAISASDFNARSELSFDSIEGRGGGAAGHGHGHGHGPGAGPTLSAITAGLQNLHTR 641
               |...|.|:.|                              |.|            .:..|..
Human   422 ---RGSHRLGSTS------------------------------HFP------------QEKTHNH 441

  Fly   642 ESRSGNGYGAGAGPGPSSELGGGGRGLPNVSDDQMLESWLEDLQATGAKIVLVTYPRTANNDKEL 706
            :.:.|:.....:.|.|                            |..|..:.|.|...|.|.:||
Human   442 DPQPGDPNSRPSSPKP----------------------------AQPALKMQVLYEFEARNPREL 478

  Fly   707 SVMRGEYLEILDDTRKWWKARNMRGQVAHVPHTIVTPFNFGDGDGAQFYGQQQQPPTGPTGPGNK 771
            :|::||.||:||.:::||..:|..|:..::|..|:.|.               ||.|
Human   479 TVVQGEKLEVLDHSKRWWLVKNEAGRSGYIPSNILEPL---------------QPGT-------- 520

  Fly   772 SRSGDNPGMEQRSPDPTDMMR 792
                  ||.:.:||....|:|
Human   521 ------PGTQGQSPSRVPMLR 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aru	NP_722663.1	PTB_EPS8	82..215	CDD:269921	35/137 (26%)
aru	NP_722663.1	SH3_Eps8	691..744	CDD:212698	19/52 (37%)
EPS8L3	XP_011540434.1	PTB_EPS8	25..154	CDD:269921	34/139 (24%)
		SH3_Eps8	464..516	CDD:212698	19/51 (37%)
		SAM_superfamily	533..598	CDD:301707	2/3 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151767
Domainoid	1	1.000	64	1.000	Domainoid score	I10104
eggNOG	1	0.900	-	-		E1_KOG3557
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D118943at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42126
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12287
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.810