DRSC/TRiP Functional Genomics Resources

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Protein Alignment aru and eps8

DIOPT Version :10

Sequence 1:NP_722663.1 Gene:aru / 33268 FlyBaseID:FBgn0029095 Length:805 Species:Drosophila melanogaster
Sequence 2:NP_001072508.1 Gene:eps8 / 779963 XenbaseID:XB-GENE-996936 Length:788 Species:Xenopus tropicalis


Alignment Length:784 Identity:207/784 - (26%)
Similarity:318/784 - (40%) Gaps:224/784 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    40 GNSSGSLRGGGAHGGGGGGG-DYSGDDRSGGG--------EERERLESD----LHDKPTYLLEHL 91
            |..|.|.|||...|.....| |....||....        |:|:....|    |.:...|.:|||
 Frog     3 GQISSSYRGGFGPGSQHPNGYDSPRSDRQSSSKISAKSIYEQRKNYARDTVSSLSETSQYHIEHL 67

  Fly    92 ATFTVNKESGIVYPADGMRRLLQLEKTTGIWSQKMQLCLDYQWVLIMDYETGNIIERFPASLVQE 156
            .||.::::.|::...||:|:|..|:....:|:|.|.|.:|.:.|.:.|.:|.:.:|.||.|.||.
 Frog    68 TTFVMDRKDGVLTVDDGIRKLKLLDAKGKVWTQDMLLQVDDKGVSLYDVDTKSELENFPLSSVQH 132

  Fly   157 PTAFTSNDAMELYNNILVFIVSGGGGSRSEMHIFQSQSVSAVHLVEDLKQLRSGKMITQQRGATP 221
            ..|..:...   |::||..:......|::::|:||...:.|..:..|:....|            
 Frog   133 CQAVMNACR---YDSILALVCKEPAQSKADLHLFQCDEIKASLVQRDIDSAIS------------ 182

  Fly   222 TQSGGGGASSMAMMMSKTSSSSSHSRVELHQHREQRAERERERDRDRERESHH----HMHQRSSM 282
             .|.||                         .:::|.|..|...|:.::...|    ......|:
 Frog   183 -DSKGG-------------------------KQKKRPEALRAITRNDDKIPPHPGAPAPTPPGSV 221

  Fly   283 EQYGIRAGVGVSGDDVAHISGETDSEHGGIGGGGATERDETSSTSSEKYERDVAVLNHCFDDIEK 347
            .|..:|:.| .:....|...|:.|.....:      ::|.|......:.:|||.:|||..||:|.
 Frog   222 TQVDVRSRV-AAWSSWASEYGDYDPSRQNL------DQDSTPEMLEARIDRDVQILNHILDDVEF 279

  Fly   348 FIARLQHAAAASRELERRRRNRKSKKRDPGEGLLTLRTRPPHEKEFVDIFAKFKLSFNLLAKLKA 412
            ||.:||.||.|..||.:|::.:  ||:.||||:||||.|||.::||||.|.|||...|||||||:
 Frog   280 FIMKLQKAAEAFSELSKRKKGK--KKKGPGEGVLTLRARPPPQEEFVDCFQKFKHGINLLAKLKS 342

  Fly   413 HIHDPNAPELVHFLFTPLALIVEASSDTYYESQLPARVVNPLLTREAINLLINCVTSKETELWRS 477
            ||.:|:|.||||||||||.::|||:..    ..|...|::||:|:::::.|...:..:|.:||.|
 Frog   343 HIQNPSASELVHFLFTPLHMMVEATGG----PDLARTVLSPLITKDSLDFLNFILNKEEKQLWTS 403

  Fly   478 LGDAWVIPRDQWKDD--VGSYHPVFLDGWSPDYLINDELEPPPNSPPAHVSKRRLEVQAGSGLNG 540
            |||:|...|.:|..:  :..|.|.|.:||          |||.....|...::.|...|.|..| 
 Frog   404 LGDSWNKYRAEWPKEQFIPPYVPRFRNGW----------EPPLLGCAAAPKEQELSYLAESVAN- 457

  Fly   541 RGGGGYDDYDSGNGMNMAMGIEKYTIHHGNDGLRERERERDRERAGAISASDFNARSELSFDSIE 605
                                            :.|.:|::           :||:          
 Frog   458 --------------------------------VAELQRKQ-----------EFNS---------- 469

  Fly   606 GRGGGAAGHGHGHGHGPGAGPTLSAITAGLQNLHTRESRSGNGYGAGAGPGPSSELGGGGRGLPN 670
                                         :.|:::..||.           |.||        .|
 Frog   470 -----------------------------VPNMYSHVSRY-----------PPSE--------GN 486

  Fly   671 VSDDQMLESWLEDLQATGAKIVLVTYPRTANNDKELSVMRGEYLEILDDTRKWWKARNMRGQVAH 735
            ..:...:|:         .:..|..|...|.|..||||::.:.||:|||.::|||.|:..|.|..
 Frog   487 FEERDQVEA---------QRYALCKYDFVARNSNELSVLKDDVLEVLDDKKQWWKVRSSSGAVGF 542

  Fly   736 VPHTIVTPFNFGDG-----DGAQFYGQQQQP-----------PTGPTGPGNKSRSGDNPGMEQRS 784
            ||:.|:......|.     :.|..:..|:|.           |..|:.|.|              
 Frog   543 VPNNILVAMKPQDQSAKPMEAAYTHTIQKQKSDLIQSQAGPIPAAPSPPPN-------------- 593

  Fly   785 PDPT 788
            |.||
 Frog   594 PAPT 597

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
aruNP_722663.1 PTB_EPS8 82..215 CDD:269921 37/132 (28%)
SH3_Eps8 691..744 CDD:212698 22/52 (42%)
eps8NP_001072508.1 PTB_EPS8 58..188 CDD:269921 40/170 (24%)
SH3_Eps8 498..551 CDD:212698 22/52 (42%)
SAM_EPS8-like 686..750 CDD:188939
Blue background indicates that the domain is not in the aligned region.

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