DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aru and Eps8l1

DIOPT Version :9

Sequence 1:	NP_722663.1	Gene:	aru / 33268	FlyBaseID:	FBgn0029095	Length:	805	Species:	Drosophila melanogaster
Sequence 2:	NP_001361551.1	Gene:	Eps8l1 / 67425	MGIID:	1914675	Length:	777	Species:	Mus musculus

Alignment Length:	761	Identity:	198/761 - (26%)
Similarity:	300/761 - (39%)	Gaps:	221/761 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 EERERLES-DLHDKPTYLLEHLATFTVNKESGIVYPADGMRRLLQLEKTTGIWSQKMQLCLDYQW 134
            |:|:|..: .:.|...|.:.||.||.:.:|.|:....|..|:|..::....:|:|:|.|.:....
Mouse    81 EQRKRYSTVVMADVSQYHVNHLVTFCLGEEDGVHTVEDASRKLAVMDSQGRVWAQEMLLRVSPSQ 145

  Fly   135 VLIMDYETGNIIERFPASLVQEPTAFTSNDAMELYNNILVFIVSGGGGSRSEMHIFQSQSVSAVH 199
            |.::|..:...:|.:|...:....|.......   .::|:.:......::.::|.||...:.|..
Mouse   146 VTLLDPVSKEELESYPLDAIVRCDAVMPRGRS---RSLLLLVCQEPERAQPDVHFFQGLLLGAEL 207

  Fly   200 LVED----LKQLRSGK--------MITQQ---RGATPTQSGG--GGASSMAMMMSKTSSSSSHSR 247
            :.||    |:..|||:        ..||:   |||:|.....  ....|:.::::....|:...|
Mouse   208 IREDIQGALQNYRSGRGERRAAALRATQEELRRGASPAAETPPLQRRPSVRLVINTVEPSAVRGR 272

  Fly   248 VELHQHREQRAERERERDRDRERESHHHMHQRSSMEQYGIRAGVGVSGDDVAHISGETDSEHGGI 312
            .::    |...|.|..|..|:.|.:.                    |.|..:...|....|..|:
Mouse   273 PQV----ESIPETEEARKPDQARTTS--------------------SADPTSPDLGPRGPELAGL 313

  Fly   313 GGGGATERDETSSTSSEKYERDVAVLNHCFDDIEKFIARLQHAAAASRELERRRRNRKSKKRDPG 377
                             :.||||.:|||.|||:|.|::|||.:|.|:|.||.|.|.|::::|..|
Mouse   314 -----------------QAERDVDILNHVFDDVESFVSRLQKSAEATRVLEHRERGRRTRRRAAG 361

  Fly   378 EGLLTLRTRPPHEKEFVDIFAKFKLSFNLLAKLKAHIHDPNAPELVHFLFTPLALIVEASSDTYY 442
            |||||||.:||.|.|:.|:..|.|.:|:|||:|:.:|.:|::|||:||||.||.:||..|....:
Mouse   362 EGLLTLRAKPPTEAEYTDVLQKIKYAFSLLARLRGNIANPSSPELLHFLFGPLQMIVNTSGGPEF 426

  Fly   443 ESQLPARVVNPLLTREAINLLINCVTSKETELWRSLGDAWVIPRDQWKDDVGS-YHPVFLDGWSP 506
            ...    |..|.||.||:.||.:.||..|.|||.||||:|..|..:...:.|| |.|.|.:||
Mouse   427 AKS----VRRPHLTLEAVTLLRDNVTPGENELWTSLGDSWTCPGVELPPEEGSPYSPEFYNGW-- 485

  Fly   507 DYLINDELEPPPNSPPAHVSKRRLEVQAGSGLNGRGGGGYDDYDSGNGMNMAMGIEKYTIHHGND 571
                    |||...|.                    |..::|           .:||...|
Mouse   486 --------EPPATDPQ--------------------GRPWED-----------PVEKQLQH---- 507

  Fly   572 GLRERERERDRERAGAISASDFNARSELSFDSIEGRGGGAAGHGHGHGHGPGAGPTLSAITAGLQ 636
                 |:.|.::.|..::.:
Mouse   508 -----EKRRRQQSAPQVAVN--------------------------------------------- 522

  Fly   637 NLHTRESRSGNGYGAGAGPGPSSELGGGGRGLPNVSDDQMLESWLEDLQATGAKIVLVTYPRTAN 701
                                        |:..|.:..:..||.       ...|.||..|...|.
Mouse   523 ----------------------------GQQDPELETESQLEE-------KARKWVLCNYDFQAR 552

  Fly   702 NDKELSVMRGEYLEILDDTRKWWKARNMRGQVAHVPHTIVTPFNFGDGDGAQFYGQQQQP----- 761
            |..||||...:.||:|||.|||||.|:.:||..:||:.|:||.     .|.|.: :.|.|
Mouse   553 NGSELSVKHRDVLEVLDDRRKWWKVRDHQGQEGYVPYNILTPH-----PGPQVH-RSQSPARHLE 611

  Fly   762 ---PTGPTGPGNKSRSGDNPGMEQRSP--DPTDMMRSKHLGKKGEF 802
               |..|..|.        |...|..|  |..|.:.|....:|.:|
Mouse   612 TSTPPPPPAPA--------PAPTQVRPQWDSCDSLNSLDPSEKEKF 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aru	NP_722663.1	PTB_EPS8	82..215	CDD:269921	31/144 (22%)
aru	NP_722663.1	SH3_Eps8	691..744	CDD:212698	26/52 (50%)
Eps8l1	NP_001361551.1	PTB_EPS8	93..223	CDD:269921	30/132 (23%)
		COG5373	220..>307	CDD:227665	21/110 (19%)
		SH3_Eps8	542..594	CDD:212698	25/51 (49%)
		SAM_EPS8-like	683..748	CDD:188939
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841870
Domainoid	1	1.000	63	1.000	Domainoid score	I10184
eggNOG	1	0.900	-	-		E1_KOG3557
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	310	1.000	Inparanoid score	I2578
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D118943at33208
OrthoFinder	1	1.000	-	-		FOG0001461
OrthoInspector	1	1.000	-	-		otm44182
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12287
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1022
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.860