DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aru and EPS8L1

DIOPT Version :9

Sequence 1:	NP_722663.1	Gene:	aru / 33268	FlyBaseID:	FBgn0029095	Length:	805	Species:	Drosophila melanogaster
Sequence 2:	XP_005259077.1	Gene:	EPS8L1 / 54869	HGNCID:	21295	Length:	755	Species:	Homo sapiens

Alignment Length:	776	Identity:	210/776 - (27%)
Similarity:	317/776 - (40%)	Gaps:	212/776 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 EERERLES-DLHDKPTYLLEHLATFTVNKESGIVYPADGMRRLLQLEKTTGIWSQKMQLCLDYQW 134
            |:|:|..: .:.|...|.:.||.||.:.::.|:....|..|:|..::....:|:|:|.|.:....
Human    20 EQRKRYSTVVMADVSQYPVNHLVTFCLGEDDGVHTVEDASRKLAVMDSQGRVWAQEMLLRVSPDH 84

  Fly   135 VLIMDYETGNIIERFPASLVQEPTAFTSNDAM---ELYNNILVFIVSGGGGSRSEMHIFQSQSVS 196
            |.::|..:...:|.:|..      |....||:   ....::|:.:......::.::|.||...:.
Human    85 VTLLDPASKEELESYPLG------AIVRCDAVMPPGRSRSLLLLVCQEPERAQPDVHFFQGLRLG 143

  Fly   197 AVHLVEDLKQLRSGKMITQQRGATPTQSGGGGASSMAMMMSKTSSSSSHSRVELHQHREQRAER- 260
            |..:.||::                      ||                    ||.:|..|.||
Human   144 AELIREDIQ----------------------GA--------------------LHNYRSGRGERR 166

  Fly   261 ---------ERERDRDRERESHHHMHQRSSMEQYGIRAGVGVSGDDVAHISGETDSEHGGIGGGG 316
                     |.:|||....|: ..:.:|.|     :||.:..    |...:|....:...|....
Human   167 AAALRATQEELQRDRSPAAET-PPLQRRPS-----VRAVIST----VERGAGRGRPQAKPIPEAE 221

  Fly   317 ATERDETSSTSSE------------------KYERDVAVLNHCFDDIEKFIARLQHAAAASRELE 363
            ..:|.|...|||.                  :.||:|.:|||.|||:|.|::|||.:|.|:|.||
Human   222 EAQRPEPVGTSSNADSASPDLGPRGPDLAVLQAEREVDILNHVFDDVESFVSRLQKSAEAARVLE 286

  Fly   364 RRRRNRKSKKRDPGEGLLTLRTRPPHEKEFVDIFAKFKLSFNLLAKLKAHIHDPNAPELVHFLFT 428
            .|.|.|:|::|..||||||||.:||.|.|:.|:..|.|.:|:|||:|:.:|.||::|||:||||.
Human   287 HRERGRRSRRRAAGEGLLTLRAKPPSEAEYTDVLQKIKYAFSLLARLRGNIADPSSPELLHFLFG 351

  Fly   429 PLALIVEASSDTYYESQLPARVVNPLLTREAINLLINCVTSKETELWRSLGDAWVIPRDQWKDDV 493
            ||.:||..|....:.|.    |..|.||.:|:.||.:.||.:|.|||.||||:|..|..:...:.
Human   352 PLQMIVNTSGGPEFASS----VRRPHLTSDAVALLRDNVTPRENELWTSLGDSWTRPGLELSPEE 412

  Fly   494 G-SYHPVFLDGWSPDYLINDELEPPPNSPPAHVSKRRLEVQAGSGLNGRGGGGYDDYDSGNGMNM 557
            | .|.|.|..||          |||...|.:.                    .::|
Human   413 GPPYRPEFFSGW----------EPPVTDPQSR--------------------AWED--------- 438

  Fly   558 AMGIEKYTIHHGNDGLRERERERDRERAGAISASDFNARSELSFDSIEGRGGGAAGHGHGHGHGP 622
              .:||...|             :|.|.....|:.            :|||....|.|.
Human   439 --PVEKQLQH-------------ERRRRQVTQATQ------------QGRGWEVRGRGR------ 470

  Fly   623 GAGPTLSAITAGLQNLHTRESRSGNGYGAGAGPGPSSELGGGGRGLPNVSDDQMLESWLEDLQAT 687
            .|.|.|:.::..||....:.:.:|:                  |.|...|:.| |||      .|
Human   471 SAWPRLTRLSYFLQQSAPQVAVNGH------------------RDLEPESEPQ-LES------ET 510

  Fly   688 GAKIVLVTYPRTANNDKELSVMRGEYLEILDDTRKWWKARNMRGQVAHVPHTIVTPFNFGDGDGA 752
            ..|.||..|...|.|..||||.:.:.||:|||:|||||.|:..||..:||:.|:||:     .|.
Human   511 AGKWVLCNYDFQARNSSELSVKQRDVLEVLDDSRKWWKVRDPAGQEGYVPYNILTPY-----PGP 570

  Fly   753 QFYGQQQ-----------QPPTGPTGPGNKSRSGDNPGMEQRSPDPTDMMRSKHLGKKGEF 802
            :.:..|.           .|...|..|...:|    |..::...|..|.:......:|.:|
Human   571 RLHHSQSPARSLNSTPPPPPAPAPAPPPALAR----PRWDRPRWDSCDSLNGLDPSEKEKF 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aru	NP_722663.1	PTB_EPS8	82..215	CDD:269921	28/135 (21%)
aru	NP_722663.1	SH3_Eps8	691..744	CDD:212698	26/52 (50%)
EPS8L1	XP_005259077.1	PTB_EPS8	32..162	CDD:269921	33/177 (19%)
		SH3_Eps8	514..567	CDD:212698	26/52 (50%)
		SAM_EPS8-like	661..726	CDD:188939
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151765
Domainoid	1	1.000	64	1.000	Domainoid score	I10104
eggNOG	1	0.900	-	-		E1_KOG3557
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	306	1.000	Inparanoid score	I2640
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D118943at33208
OrthoFinder	1	1.000	-	-		FOG0001461
OrthoInspector	1	1.000	-	-		otm42126
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12287
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1022
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.860