DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aru and eps8l1a

DIOPT Version :9

Sequence 1:	NP_722663.1	Gene:	aru / 33268	FlyBaseID:	FBgn0029095	Length:	805	Species:	Drosophila melanogaster
Sequence 2:	NP_001013331.1	Gene:	eps8l1a / 503735	ZFINID:	ZDB-GENE-050306-14	Length:	522	Species:	Danio rerio

Alignment Length:	488	Identity:	130/488 - (26%)
Similarity:	188/488 - (38%)	Gaps:	164/488 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   332 ERDVAVLNHCFDDIEKFIARLQHAAAASRELERRRRNRK----------SKKRD--PGEGLLTLR 384
            :|:|.::||||.|:|.|:||||..|.|....|:.:|::|          :||.|  |....:|
Zfish    51 QREVELVNHCFADVEHFMARLQQTAEAKNIQEQLKRSKKKSRKKNKTKRNKKEDDEPTPQKVT-- 113

  Fly   385 TRPPHEKEFVDIFAKFKLSFNLLAKLKAHIHDPNAPELVHFLFTPLALIVEASSDTYYESQLPAR 449
              ||.|:||||||.|.|.||.||.:||..|.:|::.||:|.:|.||.|:|:.:..    .:|.:.
Zfish   114 --PPSEQEFVDIFQKIKYSFCLLDRLKMKISEPSSEELLHHVFVPLQLMVKTTGG----PKLASS 172

  Fly   450 VVNPLLTREAINLLINCVTSKETELWRSLGDAWVIPRDQWKDDVGSYHPVFLDGWSPDYLINDEL 514
            :.:|.||..||:||.:.:..:|..||.|||..|.:|..|..:.|..|.|||||||.|
Zfish   173 ISSPALTSGAISLLQHNLNEQEKTLWTSLGPNWTLPYSQLSETVPQYTPVFLDGWQP-------- 229

  Fly   515 EPPPNSPPAHVSKRRLEVQAGSGLNGRGGGGYDDYDSGNGMNMAMGIEKYTIHHGNDGLRERERE 579
                           :.|.|                  ||..:...||   :.|.::.|.:.::.
Zfish   230 ---------------IAVDA------------------NGQPIEDPIE---VQHKHEALIQTQQV 258

  Fly   580 RDRERAGAISASDFNARSELSFDSIEGRGGGAAGHGHGHGHGPGAGPTLSAITAGLQNLHTRESR 644
            .|:.|......:|
Zfish   259 IDQARLTVHQEND---------------------------------------------------- 271

  Fly   645 SGNGYGAGAGPGPSSELGGGGRGLPNVSDDQMLESWLEDLQATGAKIVLVTYPRTANNDKELSVM 709
                   |..|.|.:|                            .::...:|...|.|..||||:
Zfish   272 -------GMEPLPPNE----------------------------ERMYRCSYDFVARNSSELSVL 301

  Fly   710 RGEYLEILDDTRKWWKARNMRGQVAHVPHTIVTPFNFGDGDGAQ--FYGQQQQPPTGPTGPGN-- 770
            .||.||:|:.:::|||.:|..||...|||.|:.|.|..:.|...  ...|..:.|..|...|.
Zfish   302 HGESLEVLESSKRWWKCKNSYGQTGFVPHNILEPINHAEVDSTNVVMRNQSTKAPISPLRGGRMS 366

  Fly   771 ----KSRSGDNPGMEQRSPDPTDMMRSKHLGKK 799
                ||.|..:|     .|.|..|......|:|
Zfish   367 YAAPKSESAVHP-----DPRPLSMPSFADDGEK 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aru	NP_722663.1	PTB_EPS8	82..215	CDD:269921
aru	NP_722663.1	SH3_Eps8	691..744	CDD:212698	22/52 (42%)
eps8l1a	NP_001013331.1	SH3_Eps8	283..336	CDD:212698	22/52 (42%)
eps8l1a	NP_001013331.1	SAM_EPS8-like	428..493	CDD:188939
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586345
Domainoid	1	1.000	56	1.000	Domainoid score	I10958
eggNOG	1	0.900	-	-		E1_KOG3557
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D118943at33208
OrthoFinder	1	1.000	-	-		FOG0001461
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12287
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1022
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.810