Protein Alignment aru and Eps8l1

DIOPT Version :10

• Sequence 1: NP_722663.1
• Gene: aru / 33268
• FlyBaseID: FBgn0029095
• Length: 805
• Species: Drosophila melanogaster
• Sequence 2: NP_001101937.1
• Gene: Eps8l1 / 361503
• RGDID: 1311146
• Length: 717
• Species: Rattus norvegicus
• Alignment Length: 797
• Identity: 210/797 - (26%)
• Similarity: 308/797 - (38%)
• Gaps: 260/797 - (32%)

  Fly    71 EERERLES-DLHDKPTYLLEHLATFTVNKESGIVYPADGMRRLLQLEKTTGIWSQKMQLCLDYQW 134
            |:|:|..: .:.|...|.:.||.||.:.:|.|:....|..|:|..::....:|:|:|.|.:....
  Rat    20 EQRKRYSTVVMADVSQYHVNHLVTFCLGEEDGVHTVEDASRKLAVMDSQGRVWAQEMLLRVSPGH 84

  Fly   135 VLIMDYETGNIIERFPASLVQEPTAFTSNDAMELYNNILVFIVSGGGGSRSEMHIFQSQSVSAVH 199
            |.::|..:...:|.:|...:....|.......   .::|:.:......::.::|.||...:.|..
  Rat    85 VTLLDPVSKEELESYPLDAIVRCDAVMPRGRS---RSLLLLVCQEPERAQPDVHFFQGLLLGAEL 146

  Fly   200 LVED----LKQLRSGK--------MITQQ---RGATPTQSGGGGASSMAMMMSKTSSSSSHSRVE 249
            :.||    |:..|||:        ..||:   |||:|       |:....:..:.|..:..:.||
  Rat   147 IREDIQGALQNYRSGRGERRAAALRATQEELRRGASP-------AAETPPLQRRPSVRAVINTVE 204

  Fly   250 LHQHR-----EQRAERERERDRDRERESHHHMHQRSSMEQYGIRAGVGVSGDDVAHISGETDSEH 309
            ....|     |...|.|..|..|..|.:     .|||              |..:...|....|.
  Rat   205 PSAVRGRPQVEPIPETEEARKPDPARTT-----TRSS--------------DPTSPDLGPRGPEL 250

  Fly   310 GGIGGGGATERDETSSTSSEKYERDVAVLNHCFDDIEKFIARLQHAAAASRELERRRRNRKSKKR 374
            .|:                 :.||||.:|||.|||:|.|::|||.:|.|:|.||.|.|.|::::|
  Rat   251 AGL-----------------QAERDVDILNHVFDDVESFVSRLQKSAEATRVLEHRERGRRTRRR 298

  Fly   375 DPGEGLLTLRTRPPHEKEFVDIFAKFKLSFNLLAKLKAHIHDPNAPELVHFLFTPLALIVEASSD 439
            ..||||||||.:||.|.|:.|:..|.|.:|:|||:|:.:|.:|::|||:||||.||.:||..|..
  Rat   299 AAGEGLLTLRAKPPTEAEYTDVLQKIKYAFSLLARLRGNIANPSSPELLHFLFGPLQMIVNTSGG 363

  Fly   440 TYYESQLPARVVNPLLTREAINLLINCVTSKETELWRSLGDAWVIPRDQWKDDVGS-YHPVFLDG 503
                .:.|..|..|.||.||:.||.:.||.:|.|||.||||:|..|..:...:.|| |.|.|..|
  Rat   364 ----PEFPRSVRRPHLTLEAVALLRDNVTPRENELWTSLGDSWTRPGVELPPEEGSPYSPEFYSG 424

  Fly   504 WSPDYLINDELEPPPNSPPAHVSKRRLEVQAGSGLNGRGGGGYDDYDSGNGMNMAMGIEKYTIHH 568
            |          |||...|.                    |..::|           .:||...|
  Rat   425 W----------EPPATDPQ--------------------GRPWED-----------PVEKQLQH- 447

  Fly   569 GNDGLRERERERDRERAGAISASDFNARSELSFDSIEGRGGGAAGHGHGHGHGPGAGPTLSAITA 633
                    |:.|.::.|..::.                           :||   ..|.|..
  Rat   448 --------EKRRRQQSAPQVAV---------------------------NGH---QDPELET--- 471

  Fly   634 GLQNLHTRESRSGNGYGAGAGPGPSSELGGGGRGLPNVSDDQMLESWLEDLQATGAKIVLVTYPR 698
                                                        ||.||:   ...|.||..|..
  Rat   472 --------------------------------------------ESQLEE---KARKWVLCNYDF 489

  Fly   699 TANNDKELSVMRGEYLEILDDTRKWWKARNMRGQVAHVPHTIVTPFNFGDGDGAQFYGQQQQ--- 760
            .|.|..||||...:.||:|||.|||||.|:.:||..:||:.|:||.     .|.|.:..|..
  Rat   490 QARNGSELSVKHRDVLEVLDDRRKWWKVRDHQGQEGYVPYNILTPH-----PGPQVHCSQSSAIN 549

  Fly   761 -----PPTGPTG---------------------PGNK-------------------SRSGDN--- 777
                 ||..|..                     |.:|                   .|||.:
  Rat   550 LETSPPPPPPAAAPAPTQVRPQWDSCDSLNSLDPSDKEKFSQMLCVNEELQARLAQGRSGPSRVT 614

  Fly   778 PGMEQRSPDPTDMMRSK 794
            ||:  |:|:|....||:
  Rat   615 PGL--RAPEPQLSPRSE 629

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aru	NP_722663.1	PTB_EPS8	82..215	CDD:269921	31/144 (22%)
		SH3_Eps8	691..744	CDD:212698	26/52 (50%)
Eps8l1	NP_001101937.1	PTB_EPS8	32..162	CDD:269921	30/132 (23%)
		SH3_Eps8	482..534	CDD:212698	25/51 (49%)
		SAM_EPS8-like	623..688	CDD:188939	2/7 (29%)