DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment aru and EPS8

DIOPT Version :9

Sequence 1:	NP_722663.1	Gene:	aru / 33268	FlyBaseID:	FBgn0029095	Length:	805	Species:	Drosophila melanogaster
Sequence 2:	XP_011518907.1	Gene:	EPS8 / 2059	HGNCID:	3420	Length:	842	Species:	Homo sapiens

Alignment Length:	813	Identity:	218/813 - (26%)
Similarity:	335/813 - (41%)	Gaps:	217/813 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 VPGL-----GDTMVNHHSNGGGSAGNSSGSLRGGGAHGGGGGGGDYSGDDRSGGG--------EE 72
            |||:     .|||..|.||...|.|.....:.|.|:      ...:|..||..|.        |:
Human     9 VPGIPNTQVKDTMNGHISNHPSSFGMYPSQMNGYGS------SPTFSQTDREHGSKTSAKALYEQ 67

  Fly    73 RERLESD----LHDKPTYLLEHLATFTVNKESGIVYPADGMRRLLQLEKTTGIWSQKMQLCLDYQ 133
            |:....|    :.|...|.:|||.||.::::..::...||:|:|..|:....:|:|.|.|.:|.:
Human    68 RKNYARDSVSSVSDISQYRVEHLTTFVLDRKDAMITVDDGIRKLKLLDAKGKVWTQDMILQVDDR 132

  Fly   134 WVLIMDYETGNIIERFPASLVQEPTAFTSNDAMELYNNILVFIVSGGGGSRSEMHIFQSQSVSAV 198
            .|.::|.|:.|.:|.||.:.:|...|...:.:   |:::|..:......::.::|:||...|.|.
Human   133 AVSLIDLESKNELENFPLNTIQHCQAVMHSCS---YDSVLALVCKEPTQNKPDLHLFQCDEVKAN 194

  Fly   199 HLVEDL----------KQLRSGKMITQQRGATPT--------QSGGGGASSMAMMMSKTSSSSSH 245
            .:.||:          ||.|....:.....|.|:        .....|..:...:.|:.::.|
Human   195 LISEDIESAISDSKGGKQKRRPDALRMISNADPSIPPPPRAPAPAPPGTVTQVDVRSRVAAWS-- 257

  Fly   246 SRVELHQHREQRAERERERDRDRERESHHHMHQRSSMEQYGIRAGVGVSGDDVAHISGETDSEHG 310
                        |....:.|.::.|:.|
Human   258 ------------AWAADQGDFEKPRQYH------------------------------------- 273

  Fly   311 GIGGGGATERDETSSTSSEKYERDVAVLNHCFDDIEKFIARLQHAAAASRELERRRRNRKSKKRD 375
                    |::||....:.:.:|||.:|||..||||.||.:||.||.|..||.:|::|:|.|::.
Human   274 --------EQEETPEMMAARIDRDVQILNHILDDIEFFITKLQKAAEAFSELSKRKKNKKGKRKG 330

  Fly   376 PGEGLLTLRTRPPHEKEFVDIFAKFKLSFNLLAKLKAHIHDPNAPELVHFLFTPLALIVEASSDT 440
            ||||:||||.:||...||:|.|.|||..||||||||:||.:|:|.:|||||||||.::|:|:..
Human   331 PGEGVLTLRAKPPPPDEFLDCFQKFKHGFNLLAKLKSHIQNPSAADLVHFLFTPLNMVVQATGG- 394

  Fly   441 YYESQLPARVVNPLLTREAINLLINCVTSKETELWRSLGDAWVIPRDQWKDD--VGSYHPVFLDG 503
               .:|.:.|::|||.::.|:.|...|...|.:||.|||..|:..|.:|..:  :..|.|.|.:|
Human   395 ---PELASSVLSPLLNKDTIDFLNYTVNGDERQLWMSLGGTWMKARAEWPKEQFIPPYVPRFRNG 456

  Fly   504 WSPDYLINDELEPPPNSPPAHVSKRRLEVQAGSGLNGRGGGGYDDYDSGNGMNMAMGIEKYTIHH 568
            |.|..|                                           |.|...|..:.|.:..
Human   457 WEPPML-------------------------------------------NFMGATMEQDLYQLAE 478

  Fly   569 GNDGLRERERERDRERAGA--ISASDFNARSELSFDSIEGRGGGAAGHGHGHGHGPGAGPTLSAI 631
            ....:.|.:|:::.:|...  .|.|:::.....:|.|
Human   479 SVANVAEHQRKQEIKRLSTEHSSVSEYHPADGYAFSS---------------------------- 515

  Fly   632 TAGLQNLHTRESRSGNGYGAGAGPGPSSELGGGGRGLPNVSDDQMLESWLEDLQATGAKIVLVTY 696
                 |::||.|....|..|.|.. |:|              ::.::...|.|:....|.....|
Human   516 -----NIYTRGSHLDQGEAAVAFK-PTS--------------NRHIDRNYEPLKTQPKKYAKSKY 560

  Fly   697 PRTANNDKELSVMRGEYLEILDDTRKWWKARNMRGQVAHVPHT---IVTPFNFGDGDGAQFYG-- 756
            ...|.|:.||||::.:.||||||.::|||.||..|....||:.   ||.|...|.|.....|.
Human   561 DFVARNNSELSVLKDDILEILDDRKQWWKVRNASGDSGFVPNNILDIVRPPESGLGRADPPYTHT 625

  Fly   757 -QQQQPPTGPTGPGNKSRSGDNPGMEQRSPDPT 788
             |:|:...||       |..|.|  ...||.||
Human   626 IQKQRMEYGP-------RPADTP--PAPSPPPT 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aru	NP_722663.1	PTB_EPS8	82..215	CDD:269921	38/142 (27%)
aru	NP_722663.1	SH3_Eps8	691..744	CDD:212698	23/55 (42%)
EPS8	XP_011518907.1	PTB_EPS8	84..211	CDD:269921	34/129 (26%)
		SH3_Eps8	555..608	CDD:212698	21/52 (40%)
		SAM_EPS8-like	740..804	CDD:188939
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	64	1.000	Domainoid score	I10104
eggNOG	1	0.900	-	-		E1_KOG3557
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	306	1.000	Inparanoid score	I2640
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46652
OrthoDB	1	1.010	-	-		D118943at33208
OrthoFinder	1	1.000	-	-		FOG0001461
OrthoInspector	1	1.000	-	-		otm42126
orthoMCL	1	0.900	-	-		OOG6_106655
Panther	1	1.100	-	-	LDO	PTHR12287
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4036
SonicParanoid	1	1.000	-	-		X1022
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.910