DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment aru and eps-8

DIOPT Version :9

Sequence 1:	NP_722663.1	Gene:	aru / 33268	FlyBaseID:	FBgn0029095	Length:	805	Species:	Drosophila melanogaster
Sequence 2:	NP_001360610.1	Gene:	eps-8 / 178411	WormBaseID:	WBGene00001330	Length:	943	Species:	Caenorhabditis elegans

Alignment Length:	855	Identity:	266/855 - (31%)
Similarity:	373/855 - (43%)	Gaps:	228/855 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 RSKPVPGLGDTMVNHHSNGGGSAGNSSGSLRGGGAHGGGG--------GGGDY-SGDDR------ 66
            :|:|.|  |....|..:.||..|.:.|.|.:...:|...|        ...|| :|.::
Worm    17 QSRPSP--GGYYYNRSTPGGQPAPSPSHSQQSASSHHPRGVPMSQPIARRSDYRTGSEQMTPRSD 79

  Fly    67 --------SGGGEERERLESDLHDKPTYLLEHLATFTVNKESGIVYPADGMRRLLQLEKTTGIWS 123
                    ..||...:|:: |:  .|:|.:||||||.|.::.|:.:||||:|:|.|:||.:.||:
Worm    80 HRGPSMGYGNGGSVDQRVD-DV--TPSYYVEHLATFAVGRQFGLTFPADGIRKLKQMEKNSAIWA 141

  Fly   124 QKMQLCLDYQWVLIMDYETGNIIERFPASLVQEPTAFTSNDAMELYNNILVFIVSGGG---GSRS 185
            |.:.|...:..|.:.| :.|.::|:||..|:::|||..|||:.|.|||:|:|:|....   .:.:
Worm   142 QPLILRFRHNAVTVED-DNGELVEQFPLELIEQPTAHVSNDSRETYNNVLLFVVREDRKRMSTPT 205

  Fly   186 EMHIFQSQSVSAVHLVEDLK--------QLRSGKMITQQRGATPTQSGGGGASSMAMMMSKTSSS 242
            ||||||...|||..:.||||        ::|:|:     |.|.||
Worm   206 EMHIFQCIRVSATDVAEDLKNYVQGQFRRVRNGR-----RTAAPT-------------------- 245

  Fly   243 SSHSRVELHQHREQRAERERERDRDRERESHHHMHQRSSMEQYGIRAGVGVSGDDVAHISGETDS 307
                                           |...|:..|..|         ..|.|.||.||
Worm   246 -------------------------------HLQAQQQQMPFY---------PPDDASISSET-- 268

  Fly   308 EHGGIGGGGATERDETSSTSSEKYERDVAVLNHCFDDIEKFIARLQHAAAASRELER-----RRR 367
                                ||.:||||..||.||||||:|:||:|.||.|.||:|:     |..
Worm   269 --------------------SEMFERDVNTLNRCFDDIERFVARIQSAALAQREIEQQNHRYRTA 313

  Fly   368 NRKSKKR----DPGEGLLTLRTRPPHEKEFVDIFAKFKLSFNLLAKLKAHIHDPNAPELVHFLFT 428
            ||:.||.    || .|:|.:|.:.|.|.|||||..|||||||||||||.|||:||||||:|||||
Worm   314 NRRDKKNQQPPDP-NGILFMRAQLPLESEFVDILKKFKLSFNLLAKLKNHIHEPNAPELLHFLFT 377

  Fly   429 PLALIVEASSDTYYESQLPARVVNPLLTREAINLLINCVTSKETELWRSLGDAWVIPRDQW-KDD 492
            |||:|:||.......:..|. |.:|||:.||..|:.||:||.|:::|.|||:||..|.:.| |..
Worm   378 PLAVILEACHWGLGRNVAPT-VASPLLSLEARELMQNCLTSHESDIWMSLGEAWRTPPEDWTKPL 441

  Fly   493 VGSYHPVFLDGWSPDYLINDELEPPPN-------SPPAHV----SKRRLEVQAGSGLNGRGGGGY 546
            ...|.|:|.||::| |.:.|.....||       :||.|.    .:.|..|..
Worm   442 PPPYRPIFNDGFAP-YGVADRAMATPNQIHRGHSAPPEHFRQPPPRERNMVDT------------ 493

  Fly   547 DDYDSGNGMNMAMGIEKYTIHHGNDGLRERERER---DRERAGAISASDFNARSELSFDSIEGRG 608
                :.|.........|....|.|..:...|.:|   :|||.....|......|.|..:..:...
Worm   494 ----APNTPQSMQRTPKSRPPHRNMSVDNLEFDRLTLERERLEFEKAKIMERESRLRHEEKQIED 554

  Fly   609 GGAAGHGHGHGHGPGAGPTLSAITAGLQNLHTRESRS--------------GNGYGAGAGPGPSS 659
            .....|..                   ::|.|:|:..              ...|.......|..
Worm   555 EKRRMHAE-------------------KDLITKETTQPVPPPAAVVTHQPITKRYDPPISISPPP 600

  Fly   660 ELGGGGRGLPNVSDD--QMLESWLEDLQATGAKIVLVTYPRTANNDKELSVMRGEYLEILDDTRK 722
            :..........|..|  ...:::::|:.|.|.|:.:|||.|...|.|||:|.:|||||::.|.|.
Worm   601 QRNNYSHVKVTVDSDTSPRQQAFIDDIVAKGGKLAVVTYDRGGQNTKELTVHKGEYLEVIFDERN 665

  Fly   723 WWKARNMRGQVAHVPHTIVT--PFNFGDGDGAQFYGQQQQPPTGPTGPGNKSRSGD-NPGMEQ-- 782
            ||:.:||..:|.:|||||::  ||             :||....|....|.|.:|. |.|..|
Worm   666 WWECKNMHQRVGYVPHTILSMVPF-------------EQQQYASPNHHNNSSSTGGYNNGHHQGP 717

  Fly   783 -----RSPDP 787
                 |.|.|
Worm   718 AQNVYRPPPP 727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aru	NP_722663.1	PTB_EPS8	82..215	CDD:269921	58/143 (41%)
aru	NP_722663.1	SH3_Eps8	691..744	CDD:212698	26/54 (48%)
eps-8	NP_001360610.1	PTB_EPS8	100..231	CDD:269921	56/133 (42%)
		CAF-1_p150	<526..575	CDD:371622	10/67 (15%)
		SH3_Eps8	634..687	CDD:212698	26/52 (50%)
		SAM_3	838..897	CDD:375489
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167988
Domainoid	1	1.000	110	1.000	Domainoid score	I3963
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	389	1.000	Inparanoid score	I1143
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46652
OrthoDB	1	1.010	-	-		D118943at33208
OrthoFinder	1	1.000	-	-		FOG0001461
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106655
Panther	1	1.100	-	-	LDO	PTHR12287
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4036
SonicParanoid	1	1.000	-	-		X1022
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.030