DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aru and eps8l1

DIOPT Version :9

Sequence 1:	NP_722663.1	Gene:	aru / 33268	FlyBaseID:	FBgn0029095	Length:	805	Species:	Drosophila melanogaster
Sequence 2:	XP_004916293.1	Gene:	eps8l1 / 100494819	XenbaseID:	XB-GENE-991373	Length:	751	Species:	Xenopus tropicalis

Alignment Length:	782	Identity:	190/782 - (24%)
Similarity:	306/782 - (39%)	Gaps:	232/782 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 EERERLES-DLHDKPTYLLEHLATFTVNKESGIVYPADGMRRLLQLEKTTGIWSQKMQLCLDYQW 134
            |:|::..: .:.|...|.:.||.|||:.::..:....|.:|:|..::....||.|:|.:.::...
Frog    20 EQRKKYSNVIMADVSQYQVHHLVTFTIGEDDDVHTVEDAIRKLNAVDSKGKIWIQEMLIEVNSSV 84

  Fly   135 VLIMDYETGNIIERFPASLVQEPTAFTSNDAMELYNN-ILVFIVSGGGGSRSEMHIFQSQSVSAV 198
            |.::|..:...:|.||.|.:|.    ......|..|: :|:.:.......:.:::.|||..|:|
Frog    85 VKLVDVNSKEELEEFPLSAIQR----CDTVLPERRNHPLLILVCQDTYQPKPDVYFFQSDYVAA- 144

  Fly   199 HLV-EDLKQLRSGKMITQQRGATPTQSGGGGASSMA----MMMSKTSSSSSHSRVELHQHREQRA 258
            ||: ||:..           ..:..|||.......|    |......:...::...|.|.|:..:
Frog   145 HLIKEDINS-----------AVSDFQSGVNAKRPEALRNNMEQIAQGAPGPNTFTPLGQWRQPTS 198

  Fly   259 ---------ERERER-----------------DRDRERES-----------HHHMHQRSSMEQYG 286
                     |||.:|                 ..|:.::|           :..:.:....:|:.
Frog   199 QYVTPAEILEREAQRKPMVKPPRSSLTKIIVSSTDQGQQSIETPQYPQEPLYSEIKRHDKPQQFV 263

  Fly   287 IRAGVGVSGDDVAHISGETDSEHGGIGGGGATERDETSSTSSEKYERDVAVLNHCFDDIEKFIAR 351
            ..:|..........:.||..::...:..|                 .:|.:|||||||||.|:..
Frog   264 QESGSPQLQQKTLKVPGEAATDPSAVRSG-----------------HEVDLLNHCFDDIEFFMGS 311

  Fly   352 LQHAAAASRELERRRRNRKSKKRDPGEGLLTLRTRPPHEKEFVDIFAKFKLSFNLLAKLKAHIHD 416
            ||.:|.|.:.|.:|:::|::||::.||||||||.:||..:|:.|...|||..|.|||:|:.:|.:
Frog   312 LQKSAEAFKMLNQRKKSRRTKKKEAGEGLLTLRAKPPRIEEYEDAVRKFKYCFCLLARLRNNIVN 376

  Fly   417 PNAPELVHFLFTPLALIVEASSDTYYESQLPARVVNPLLTREAINLLINCVTSKETELWRSLGDA 481
            |:|.|||||||.||..:|::....    ::||.:..||||.||:..|...:..:|.|||.|||..
Frog   377 PSAIELVHFLFGPLRTLVDSCGGV----EMPAEITTPLLTNEAVTFLKESLNEQELELWTSLGPN 437

  Fly   482 WVIPRDQW-KDDVGSYHPVFLDGWSPDYLINDELEPPPNSPPAHVSKRRLEVQAGSGLNGRGGGG 545
            |..||.:: |:....|.|.|..||.|
Frog   438 WTKPRLEYPKEFCQPYTPTFRSGWVP--------------------------------------- 463

  Fly   546 YDDYDSGNGMNMAMGIEKYTIHHGNDGLRERERERDRERAGAISASDFNARSELSFDSIEGRGGG 610
                .|.||......||   :.|.::.||.::           ||...|.
Frog   464 ----VSTNGKPWEDPIE---LQHRHEELRAQQ-----------SAPQVNI--------------- 495

  Fly   611 AAGHGHGHGHGPGAGPTLSAITAGLQNLHTRESRSGNGYGAGAGPGPSSELGGGGRGLPNVSDDQ 675
                                                        |.|...:.|.
Frog   496 --------------------------------------------PAPIPAVNGH----------- 505

  Fly   676 MLESWLEDLQATGAKIVLVTYPRTANNDKELSVMRGEYLEILDDTRKWWKARNMRGQVAHVPHTI 740
                     :.|.||.|..||...|.|..||||:.||.||::||::||||.:|..||:.:||:.|
Frog   506 ---------EETDAKRVSCTYDFVARNSSELSVLHGEVLEVIDDSKKWWKVQNRFGQIGYVPYNI 561

  Fly   741 VTPFNFGDGDGAQFYGQQQQ------PPTGPTGPGNKSRSGDNPGMEQRSPDPTDMMRSKHLGKK 799
            :.|:...|.:.|...|.||.      ||..|..|.|        |:.:.|.|.::.:..:.:.::
Frog   562 LAPYTATDANKANVNGSQQSSPSKVPPPKPPKKPSN--------GIARNSWDQSNGLNQEQITEQ 618

  Fly   800 GE 801
            |:
Frog   619 GK 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aru	NP_722663.1	PTB_EPS8	82..215	CDD:269921	33/134 (25%)
aru	NP_722663.1	SH3_Eps8	691..744	CDD:212698	25/52 (48%)
eps8l1	XP_004916293.1	PTB_EPS8	32..162	CDD:269921	35/145 (24%)
		SH3_Eps8	513..565	CDD:212698	25/51 (49%)
		SAM_EPS8-like	657..722	CDD:188939
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	66	1.000	Domainoid score	I9760
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	280	1.000	Inparanoid score	I2834
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D118943at33208
OrthoFinder	1	1.000	-	-		FOG0001461
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12287
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1022
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.070