DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4291 and Wbp4

DIOPT Version :9

Sequence 1:	NP_001259846.1	Gene:	CG4291 / 33264	FlyBaseID:	FBgn0031287	Length:	338	Species:	Drosophila melanogaster
Sequence 2:	NP_061235.2	Gene:	Wbp4 / 22380	MGIID:	109568	Length:	376	Species:	Mus musculus

Alignment Length:	397	Identity:	117/397 - (29%)
Similarity:	187/397 - (47%)	Gaps:	81/397 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTEYWKSNERKFCDFCKCWLSDNKASVAFHESGKRHKMNVAKRITDISRNSEKSERERQKMDAEI 65
            |.:||||..:||||:||||::||:.||.|||.||.||.|||:||::|.:.|....:|.:|...|.
Mouse     1 MADYWKSQPKKFCDYCKCWIADNRPSVEFHERGKNHKENVARRISEIKQKSLDKAKEEEKASKEF 65

  Fly    66 RKMEEAAMKSYAQDVHSRG--------DMTARSINTVMRATATA--------------AASGG-- 106
            ..||.||:|:|.:|:...|        :.|...:.:.::.|.|:              |:.||
Mouse    66 AAMEAAALKAYQEDLKRLGLPLPSDISEPTVSPVISTVQPTPTSNQQKEKKKKKKKKEASKGGWV 130

  Fly   107 ------AHSF-----AGRSRQVDPMRLEGLSDEEEDQRRVAPGKVTSDAAVPEASLWVEGKSDEG 160
                  .|.:     .|.|:...|   ||..           |.:...||   .::||||.|::|
Mouse   131 EGVTADGHCYYYDLITGASQWEKP---EGFQ-----------GNLKKTAA---KAVWVEGLSEDG 178

  Fly   161 HTYYWNVKTNESVWKPPKE------GYLSYEEYERI-----NQLAIDQQQISQAEESLKFRANVD 214
            :|||:|.:|.||.|:.|::      ..||.::..::     :..:.|....|:.|:.....|:.:
Mouse   179 YTYYYNTETGESKWEKPEDFIPHGGDVLSSKDSGKLPDTLEDAKSSDSHSDSEGEQKKAGEASTE 243

  Fly   215 EEVARVN-REKMKAFRRTDNPKEKKQKEERRQT-FKTEEE------AATKEIGQWQTVEVKAPEQ 271
            .:...:. :||.|:..:...|:.:|:|...:|. ..|.||      .:|...|:||.::.:|..|
Mouse   244 TKKLIIKFKEKNKSTEKRIGPEIQKEKSTPKQNPSNTNEEKPKTLKKSTNPYGEWQEIKQEAESQ 308

  Fly   272 -PIDWQLPKTDYYSAAPVVSASSEPEPPVK-KFKEKTIGGLDEEIAATAPATFKRKFIRKG---N 331
             .:|.:||.|:    ...:|.|......:| .|||||:..|.......|| .||::.:..|   |
Mouse   309 EEVDLELPSTE----GECLSTSEAGVGEIKVVFKEKTVSSLGVAADGVAP-VFKKRRLENGKSRN 368

  Fly   332 SRQRAED 338
            .|||.:|
Mouse   369 LRQRGDD 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4291	NP_001259846.1	zf-U1	10..44	CDD:277622	22/33 (67%)
CG4291	NP_001259846.1	WW	152..177	CDD:278809	14/24 (58%)
Wbp4	NP_061235.2	zf-U1	8..44	CDD:114912	22/35 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	94..127		4/32 (13%)
		WW	126..156	CDD:238122	6/32 (19%)
		WW	170..195	CDD:278809	14/24 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	192..324		28/135 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850576
Domainoid	1	1.000	62	1.000	Domainoid score	I10379
eggNOG	1	0.900	-	-		E1_KOG0150
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38287
Inparanoid	1	1.050	144	1.000	Inparanoid score	I4414
Isobase	1	0.950	-	0	Normalized mean entropy	S5272
OMA	1	1.010	-	-		QHG45581
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004807
OrthoInspector	1	1.000	-	-		oto94262
orthoMCL	1	0.900	-	-		OOG6_106550
Panther	1	1.100	-	-	LDO	PTHR13173
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1967
SonicParanoid	1	1.000	-	-		X4650
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740