DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drongo and git2a

DIOPT Version :9

Sequence 1:	NP_001162848.1	Gene:	drongo / 33263	FlyBaseID:	FBgn0020304	Length:	673	Species:	Drosophila melanogaster
Sequence 2:	XP_005165241.1	Gene:	git2a / 793882	ZFINID:	ZDB-GENE-060526-267	Length:	804	Species:	Danio rerio

Alignment Length:	718	Identity:	129/718 - (17%)
Similarity:	221/718 - (30%)	Gaps:	256/718 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 CFDCGQKGPTYVNMTIGSFVCTRCSGVLRGLTPPH-RVKSISMATFTQDEIDFLRSHGNELCAKT 93
            |.||....|.:.::..|..:|..|..|.|.|...: :|:.:|..::...::..:::..|......
Zfish    21 CADCSTSDPRWASVNRGVLICDECCSVHRSLGRHNSQVRHLSNTSWPPTQLQMVQTLYNNGANAI 85

  Fly    94 WLGLWDPKRAVHQQEQRELMMDKYERKRYYLEPASPLKSLANAVNLKSSAPATNHTQNGHQNG-- 156
            |                         :...|:|:|          :.||....||....|.|.
Zfish    86 W-------------------------EHTLLDPSS----------IMSSKRKPNHQDKLHPNKAD 115

  Fly   157 --------YASIHLTP-PAAQRTSANGLQKVANSSSNSSG-----KTSSSISRPHYNHQNNSQNN 207
                    .|.:|..| .....|:|..|.|..:||..:..     :..|..::.:|.|.......
Zfish   116 FIKAKYQMLAYVHRLPCRDDDSTAAADLSKQLHSSVRTGNLETCLRLLSLGAQANYFHPEKGNTP 180

  Fly   208 NHDAFGLGGGLSSLNSAGSTSTGALSDTSSCASNGFGADCDFVADFGSANIFDATSARSTGSPAV 272
            .|.|          ..||......|    .|.   :|||                    .|:|..
Zfish   181 LHIA----------AKAGQVCQAEL----LCV---YGAD--------------------PGAPDS 208

  Fly   273 SSVSSVGSSNGYAKVQPIRAAHLQQQQQLQQQLHQQQLLNGNGHQGTENFADF------DHAPIY 331
            |..:.:    .||:    :|.|    |.|..:|.:.|      ::.|:..|.:      ||....
Zfish   209 SGKTPI----NYAR----QAGH----QDLADRLVEIQ------YELTDRLAFYLCGRKPDHKSGQ 255

  Fly   332 NAVAPPTFNDWIS----DWSRRGFHDPFDDCDDSPPGARPPAPAPAPAQVPAVSSPLPTVREEPE 392
            :.:.|...:..:|    ::::                       .|..::.::|..|     ..|
Zfish   256 HFIIPQMADRNVSVELTEFAK-----------------------AAKRKLQSLSDHL-----FEE 292

  Fly   393 LAWNFWEDEMRIEAQEKESQTKQPELGYSFSISTTTPLSPSNPFLPYLVSEEQHRNHPEKPSFSY 457
            ||.:.:::..|.|.......|:    .:|..::.||.:    ||||.         :||
Zfish   293 LAMDVYDEVDRRETDAVWLATQ----NHSTLVTETTVV----PFLPV---------NPE------ 334

  Fly   458 SLFSSISNSSQEDQADDHEMNVLNANFHDFFTWSAPL-------QNGHTTSPPK---------GG 506
              :||..|..::..|        ..|.|:|.|....:       |:|:....||         ||
Zfish   335 --YSSTRNQGRQKLA--------RFNAHEFATLVIDILSDAKRRQHGNPVPSPKDNVDVFFKSGG 389

  Fly   507 NAAMA-------PSEDRYAALKDLDEQLRELKASES------ATETPTPTSGNVQATDAFGGA-- 556
            :...:       |..|..|:.:|.|..||..||..:      .::.|......::..:|...:
Zfish   390 SRHGSESQEIDQPDYDSVASDEDTDTDLRMGKADRTKSLDSDLSDGPVSVQEFLEVKNALSASEA 454

  Fly   557 -------LNNNPNPFKGQQQQQLSS------------HVVNPFQQQQQQQHQQNLYGQLTLIPN- 601
                   .|:|.|......|::|.|            ....|:|......|           ||
Zfish   455 KIQELMKANSNLNEELRLMQKKLQSLQSENSSLRRQVSAQQPYQAPGGPDH-----------PNP 508

  Fly   602 ------AYGSSSQQQMGHHLLQQQQQQQQSFFNFNNNGFAISQGLPNG------CGFGSMQPAPV 654
                  :..|||...:..||..:..:....:    ..|..:...||.|      ..|.::||.|.
Zfish   509 SSPSSCSSSSSSSSALKRHLSARASRPMSMY----ETGSGLKPFLPKGETPYPEETFPTLQPFPA 569

  Fly   655 MAN 657
            .|:
Zfish   570 YAS 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drongo	NP_001162848.1	ArfGap	15..126	CDD:279720	15/96 (16%)
git2a	XP_005165241.1	ArfGap	12..134	CDD:214518	26/147 (18%)
		Ank_2	147..239	CDD:289560	26/146 (18%)
		ANK	<147..230	CDD:238125	23/131 (18%)
		ANK repeat	147..175	CDD:293786	5/27 (19%)
		ANK repeat	177..207	CDD:293786	10/66 (15%)
		GIT_SHD	278..306	CDD:285690	7/32 (22%)
		GIT_SHD	342..369	CDD:285690	5/34 (15%)
		GIT_CC	426..490	CDD:293167	8/63 (13%)
		GIT1_C	632..798	CDD:289013
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900