DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment drongo and Acap2

DIOPT Version :9

Sequence 1:	NP_001162848.1	Gene:	drongo / 33263	FlyBaseID:	FBgn0020304	Length:	673	Species:	Drosophila melanogaster
Sequence 2:	XP_006522806.1	Gene:	Acap2 / 78618	MGIID:	1925868	Length:	816	Species:	Mus musculus

Alignment Length:	348	Identity:	69/348 - (19%)
Similarity:	134/348 - (38%)	Gaps:	99/348 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 NRQCFDCGQKGPTYVNMTIGSFVCTRCSGVLRGLTPPH--RVKSISMATFTQDEIDFLRSHGNEL 89
            |..|.|||...|.:.::.:|..:|..|||:.|.| ..|  :|:|:::.|:..:.:..:...||::
Mouse   422 NTSCCDCGLADPRWASINLGITLCIECSGIHRSL-GVHFSKVRSLTLDTWEPELLKLMCELGNDV 485

  Fly    90 CAKTW------LGLWDPKRAVHQQEQRELMMDKYERKRY---YLEPASPLKSLANAVNLKSSAPA 145
            ..:.:      :|:..|:.. .:||:...:..||..:::   |....||.:.....::.......
Mouse   486 INRVYEAKLEKMGVKKPQPG-QRQEKEAYIRAKYVERKFVDKYSALLSPSEQEKRIISKSCEDQR 549

  Fly   146 TNHTQNGHQNGYASIHLTPPAAQ--------------------------------RTSANGLQKV 178
            .:|.:       ||:| ||.||.                                :::.:|:|:.
Mouse   550 LSHAR-------ASVH-TPVAAVTSDEARRESLFCPDELDSLFSYFDTSSKLRSIKSNDSGIQQC 606

  Fly   179 ANSSSNS--SGKTSSSISRPHYNHQNNS--QNNNHDAFGLGGGLSSLNSAGSTSTGALSDTSSCA 239
            :.....|  |..:::|:..|....|.:|  .::.|    |..||....::...:...:::..:
Mouse   607 SEDGRESLPSTVSANSLYEPEGERQESSVFLDSKH----LNPGLQLYRASYEKNLPKMAEALA-- 665

  Fly   240 SNGFGADCDFVADFGSANIFDATSARSTGSPAVSSVSSVGSS---------NGYAKVQPIRAAHL 295
               .|||.::           |.|..:..:|.:.:|  :|.|         || |.|.
Mouse   666 ---HGADVNW-----------ANSDENQATPLIQAV--LGGSLVTCEFLLQNG-ANVN------- 706

  Fly   296 QQQQQLQQQLHQQQLLNGNGHQG 318
            |:..|.:..||...:|   ||.|
Mouse   707 QRDVQGRGPLHHATVL---GHTG 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drongo	NP_001162848.1	ArfGap	15..126	CDD:279720	26/109 (24%)
Acap2	XP_006522806.1	BAR_ACAP2	18..217	CDD:153322
		PH_ACAP	273..376	CDD:270070
		COG5347	398..>635	CDD:227651	43/222 (19%)
		ArfGap_ACAP2	410..524	CDD:350076	25/103 (24%)
		Ank_4	648..699	CDD:372654	9/68 (13%)
		ANK repeat	676..709	CDD:293786	9/42 (21%)
		PTZ00322	680..>764	CDD:140343	16/60 (27%)
		ANK repeat	711..742	CDD:293786	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910